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Metabolites
Volume 12
Issue 9
10.3390/metabo12090820
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Article
Peer-Review Record

Urinary Levels of miR-491-5p and miR-592 as Potential Diagnostic Biomarkers in Female Aging Patients with OAB: A Pilot Study

Metabolites 2022, 12(9), 820; https://doi.org/10.3390/metabo12090820
by Philippe G. Cammisotto 1, Abubakr H. Mossa 1, Samer Shamout 1,2 and Lysanne Campeau 1,2,*
Reviewer 2: Anonymous
Reviewer 3:
Sakineh Hajebrahimi
Metabolites 2022, 12(9), 820; https://doi.org/10.3390/metabo12090820
Submission received: 12 July 2022 / Revised: 17 August 2022 / Accepted: 19 August 2022 / Published: 31 August 2022
(This article belongs to the Special Issue Crosstalk between Metabolic Syndrome and Voiding Dysfunction)

Round 1

Reviewer 1 Report

the authors reported their experience on Urinary levels of miR-491-5p and miR-592 as potential diagnostic biomarkers in female aging patients with OAB.

the research was clearly presented.

I would suggest some revisions in order to improve the quality of the paper:

- were patients consecutive?

- please add a flow chart for included and excluded patients

- please add a sample size calculation

- please add a matching pair analysis

Author Response

Please see the attachment.

 

Author Response File: Author Response.pdf

Reviewer 2 Report

The paper presented for review concerns the potential use of miR-491-5p and miR-592 levels as a biomarker of the overactive bladder syndrome. The authors point to increased levels of microRNAs in patients compared to controls. The reviewer was interested in the issue of patients suffering from OBA. The authors indicated that samples from patients with and without treatment were selected for the study. The reviewer asks for an explanation of the differences in the levels of the examined indicators in both groups. Did the treatment significantly affect the obtained results? Have the authors considered enlarging the group of patients and treating them separately - those with and without treatment? The treatment used can significantly affect the results. Apart from the indicated doubts, the work is very interesting.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

The definition of OAB should be based on the ICS glossary.

Most references should be updated.

 What were your selection criteria for OAB? Please mention it in the method section.

 Why did you consider only women aged 50-80 years? Please describe the rationale of your study in the introduction.

What was the study design? How did you match the case and controls, and with which criteria?

 

All of the abbreviations should be described in the legends of tables.  

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

All of my comments responded satisfactorily. 

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