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Volume 13
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Review

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

by
Lucas Fornari Laurindo
1,2,
Mariana Canevari de Maio
2,
Giulia Minniti
1,
Natália de Góes Corrêa
1,
Sandra Maria Barbalho
1,3,4,
Karina Quesada
1,4,
Elen Landgraf Guiguer
1,3,4,
Kátia Portero Sloan
5,
Claudia R. P. Detregiachi
1,3,
Adriano Cressoni Araújo
1,3 and
Ricardo de Alvares Goulart
3,*
1
Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil
2
Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Avenida Monte Carmelo, 800, Marília 17519-030, São Paulo, Brazil
3
Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil
4
Department of Biochemistry and Nutrition, School of Food and Technology of Marília (FATEC), Avenida Castro Alves, 62, Marília 17500-000, São Paulo, Brazil
5
Texas Institute for Kidney and Endocrine Disorders, Lufkin, TX 75904, USA
*
Author to whom correspondence should be addressed.
Metabolites 2023, 13(2), 243; https://doi.org/10.3390/metabo13020243
Submission received: 5 January 2023 / Revised: 2 February 2023 / Accepted: 6 February 2023 / Published: 7 February 2023
(This article belongs to the Special Issue Effects of Medicinal Plants on Inflammatory Bowel Disease and Other Gastrointestinal Diseases: Biochemical Aspects, Metabolomics, and Strategies of Plant-Based Therapy)
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Abstract

Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2 (Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling in IBD have already been published. However, no existing review emphasizes the whole scenario for the potential of plants and phytocompounds as regulators of Nrf2 in IBD models and colitis-associated colorectal carcinogenesis. For these reasons, this study aimed to build a review that could fill this void. The PubMed, EMBASE, COCHRANE, and Google Scholar databases were searched. The literature review showed that medicinal plants and phytochemicals regulated the Nrf2 on IBD and IBD-associated colorectal cancer by amplifying the expression of the Nrf2-mediated phase II detoxifying enzymes and diminishing NF-κB-related inflammation. These effects improve the bowel environment, mucosal barrier, colon, and crypt disruption, reduce ulceration and microbial translocation, and consequently, reduce the disease activity index (DAI). Moreover, the modulation of Nrf2 can regulate various genes involved in cellular redox, protein degradation, DNA repair, xenobiotic metabolism, and apoptosis, contributing to the prevention of colorectal cancer.
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; medicinal plants; phytochemicals; inflammation; oxidative stress; apoptosis inflammatory bowel disease; Crohn’s disease; ulcerative colitis; medicinal plants; phytochemicals; inflammation; oxidative stress; apoptosis
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MDPI and ACS Style

Laurindo, L.F.; de Maio, M.C.; Minniti, G.; de Góes Corrêa, N.; Barbalho, S.M.; Quesada, K.; Guiguer, E.L.; Sloan, K.P.; Detregiachi, C.R.P.; Araújo, A.C.; et al. Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review. Metabolites 2023, 13, 243. https://doi.org/10.3390/metabo13020243

AMA Style

Laurindo LF, de Maio MC, Minniti G, de Góes Corrêa N, Barbalho SM, Quesada K, Guiguer EL, Sloan KP, Detregiachi CRP, Araújo AC, et al. Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review. Metabolites. 2023; 13(2):243. https://doi.org/10.3390/metabo13020243

Chicago/Turabian Style

Laurindo, Lucas Fornari, Mariana Canevari de Maio, Giulia Minniti, Natália de Góes Corrêa, Sandra Maria Barbalho, Karina Quesada, Elen Landgraf Guiguer, Kátia Portero Sloan, Claudia R. P. Detregiachi, Adriano Cressoni Araújo, and et al. 2023. "Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review" Metabolites 13, no. 2: 243. https://doi.org/10.3390/metabo13020243

APA Style

Laurindo, L. F., de Maio, M. C., Minniti, G., de Góes Corrêa, N., Barbalho, S. M., Quesada, K., Guiguer, E. L., Sloan, K. P., Detregiachi, C. R. P., Araújo, A. C., & de Alvares Goulart, R. (2023). Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review. Metabolites, 13(2), 243. https://doi.org/10.3390/metabo13020243

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