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Biomolecules
Volume 11
Issue 12
10.3390/biom11121873
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Review
Peer-Review Record

Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution

Biomolecules 2021, 11(12), 1873; https://doi.org/10.3390/biom11121873
by Undurti N Das 1,2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Biomolecules 2021, 11(12), 1873; https://doi.org/10.3390/biom11121873
Submission received: 4 November 2021 / Revised: 8 December 2021 / Accepted: 9 December 2021 / Published: 14 December 2021
(This article belongs to the Special Issue Inflammatory Pathways in Neuro-Muscular Degeneration, Metabolic Syndromes, Cancer and Infection)

Round 1

Reviewer 1 Report

This article summarizes previously obtained data on the involvement of essential fatty acids and their metabolites in the pathobiology and resolution of inflammation. The article analyzes a significant number of high-level theoretical and experimental papers that deserve attention. It is worth noting and welcoming the detailed approach of the article to the description of the corresponding processes and their mechanisms. This article will undoubtedly be useful to researchers in the field of inflammatory processes of various etiologies for understanding and detailed analysis of the interaction of essential fatty acids and various pro- and anti-inflammatory factors. I am sure that this material should find the widest response from the readership and lead to an important advancement in this research area. This is especially true in the current global epidemic situation. It is worth noting that on the basis of the experimental and theoretical data presented, new approaches and medical devices should be developed using them to help against severe inflammatory processes. I believe that the article deserves publication, even despite minor technical flaws in terms of the quality of some of the figures. I am sure that, if necessary, they can be easily corrected by respected authors.

Author Response

I thank the reviewer for nice suggestions and encouragement about the work. I modified the figures as suggested by the reviewer. The text of the article has been read and minor spelling errors have been corrected.   

Reviewer 2 Report

This work is an excellent contribution on the role of essential fatty acids in inflammation and resolution. It gives a clear and detailed feedback on the role of AA mediators in the pathobiology of ischemia/reperfusion injury, sepsis, COVID-19, and other critical illnesses. Well done to the author!

Author Response

I thank the reviewer for the comments and suggestions. All these has been addressed.

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