Concerted Actions by PIICP, CTXII, and TNF-α in Patients with Juvenile Idiopathic Arthritis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Samples
2.2. The Assay of the Concentration of PIICP, CTXII, and TNF-α
2.3. Statistical Analysis
3. Results
3.1. The Serum Levels of PIICP in Healthy Children and JIA Patients
3.2. The Serum Levels of CTXII in Healthy Children and JIA Patients
3.3. The Serum Levels of TNF-α in Healthy Children and JIA Patients
3.4. The Correlations between Markers of Metabolic Changes of Cartilage and TNF-α
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Control Subjects (n = 45) | JIA Patients before Treatment (n = 96) | JIA Patients after Treatment | |
---|---|---|---|---|
Inactive Disease (n = 30) | Active Disease (n = 66) | |||
Age (years) | 8.25 ± 2.03 | 8.23 ± 3.48 | 8.71 ± 3.70 | 7.95 ± 2.51 |
Sex, female/male | 34/11 | 77/19 | 19/11 | 58/8 |
JADAS-27 | - | 18 ± 8.66 | 4 ± 2.48 b | 15 ± 4.57 |
BMI (kg/m2) | 18.34 ± 2.12 | 16.18 ± 2.14 a | 18.02 ± 3.55 b | 16.67 ± 3.12 a |
WBC (103/µL) | 7.85 ± 2.34 | 14.66 ± 4.59 a | 6.45 ± 2.70 | 9.72 ± 2.18 b |
RBC (106/µL) | 4.75 ± 0.32 | 4.26 ± 0.42 | 4.62 ± 0.36 | 4.02 ± 0.33 a |
Hb (g/dL) | 14.08 ± 0.74 | 11.25 ± 1.78 a | 12.94 ± 1.53 a,b | 12,02 ± 1.27 a,b |
Ht (%) | 40.68 ± 3.26 | 35.67 ± 3.52 a | 37.22 ± 7.51 a,b | 37.19 ± 3.57 a,b |
PLT (103/µL) | 284.42 ± 68.22 | 398.26 ± 111.87 a | 359.26 ± 80.06 b | 344.32 ± 70.15 |
Total cholesterol (mM/L) | 4.32 ± 0.84 | 4.69 ± 1.39 a | 4.27 ± 1.55 b | 4.48 ± 0.69 |
Glucose (mM/L) | 4.21 ± 0.38 | 4.18 ± 1.26 | 4.44 ± 0.56 b | 4.51 ± 0.93 b |
Creatinine (µM/L) | 61.42 ± 12.45 | 77.58 ± 9.21 a | 64.35 ± 14.57 a,b | 82.58 ± 1.11 a,b |
CRP (mg/L) | 1.20 ± 1.39 | 19.66 ± 21.68 a | 3.57 ± 0.62 b | 12.47 ± 16.88 a,c |
ESR (mm/h) | 9.22 ± 7.41 | 41.66 ± 22.04 a | 12.01 ± 5.15 b | 24.95 ± 15.89 a,c |
ANA | - | 57% (positive) | 57% (positive) | 57% (positive) |
RF | - | 100% (negative) | 100%(negative) | 100% (negative) |
Parameter | Control Subjects (n = 45) | JIA Patients before Treatment | JIA Patients after Treatment | ||
---|---|---|---|---|---|
A (n = 30) | B (n = 66) | A’ (Inactive Disease) (n = 30) | B’ (Active Disease) (n = 66) | ||
PIICP (ng/mL) | 44.62 ± 10.66 | 62.00 ± 23.48 a | 59.18 ± 18.71 b | 45.33 ± 13.10 e | 74.64 ± 18.81 a,f,i |
CTX II (ng/mL) | 0.81 ± 0.21 | 1.43 ± 0.75 c | 1.42 ± 0.59 c | 0.98 ± 0.32 d,g | 1.58 ± 0.67 c,i |
TNF-α (pg/mL) | 7.19 ± 0.71 | 9.85 ± 4.96 d | 10.11 ± 5.02 d | 7.56 ± 2.76 e | 12.88 ± 6.86 c,h,j |
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Winsz-Szczotka, K.; Kuźnik-Trocha, K.; Lachór-Motyka, I.; Lemski, W.; Olczyk, K. Concerted Actions by PIICP, CTXII, and TNF-α in Patients with Juvenile Idiopathic Arthritis. Biomolecules 2021, 11, 648. https://doi.org/10.3390/biom11050648
Winsz-Szczotka K, Kuźnik-Trocha K, Lachór-Motyka I, Lemski W, Olczyk K. Concerted Actions by PIICP, CTXII, and TNF-α in Patients with Juvenile Idiopathic Arthritis. Biomolecules. 2021; 11(5):648. https://doi.org/10.3390/biom11050648
Chicago/Turabian StyleWinsz-Szczotka, Katarzyna, Kornelia Kuźnik-Trocha, Iwona Lachór-Motyka, Wojciech Lemski, and Krystyna Olczyk. 2021. "Concerted Actions by PIICP, CTXII, and TNF-α in Patients with Juvenile Idiopathic Arthritis" Biomolecules 11, no. 5: 648. https://doi.org/10.3390/biom11050648