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Biomolecules
Volume 13
Issue 1
10.3390/biom13010050
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Review
Peer-Review Record

Hypoxia-Inducible Factor 1 and Mitochondria: An Intimate Connection

Biomolecules 2023, 13(1), 50; https://doi.org/10.3390/biom13010050
by Xiaochen Huang, Li Zhao * and Ruiyun Peng *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3:
Adel Bakr
Biomolecules 2023, 13(1), 50; https://doi.org/10.3390/biom13010050
Submission received: 25 November 2022 / Revised: 21 December 2022 / Accepted: 21 December 2022 / Published: 27 December 2022
(This article belongs to the Special Issue Advances in Mitochondrial Calcium Research)

Round 1

Reviewer 1 Report

The present review titled “Hypoxia-inducible factor 1 and mitochondria: an intimate connection” is focused on interaction and connection between HIF-1 and mitochondria. The interrelationships between HIF-1 and mitochondria represent interesting targets for developing new drugs and  treatment that involve energy metabolism and hypoxia adaptation.

 The reference list is old and I suggest its updating.

Overall, the manuscript is well written, even if some minor stylistic revisions should be made.

 

I think this review is acceptable for publication in Biomolecules.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This is a very detailed (sometimes too detailed) review of a complex issue that tries to highlight the interrelation between hypoxia, the hypoxia-responsive element HIF-1, and mitochondria function in the cell. The review is generally written well, touching on all the important issues in the mutual interactions between mitochondria and HIF-1. Although the review concentrates on HIF-1, I would have expected that in the introduction and conclusion sections,  the mention of an additional pathway controlled by CREB that was shown to be a hypoxia-responsive regulator, plays an important role in the expression of genes in the mitochondria.

specific comments

line 43:  "The HIF complex is abundant when oxygen is present"  is this true?

line 50: the word "exactly " should not be used here

lines 80-82: are repeated in lines 86-88

lines 83-84: please clearify.

lines 98-99: is the number of mitochondria stable or as written in the same sentence " the number will change with the fluctuation of cell function"?

4.1.2 please explain the differences in mitochondria function in the cell under anterograde movement and retrograde.

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

review is very good, but i have two comments:

1. can you explain in details the role of iron in mitochonria during hypoxia

2. The review needs some further recent  references

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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