Polyphenols, Autophagy and Neurodegenerative Diseases: A Review
Abstract
:1. Introduction
2. Absorption, Distribution, Metabolism and Excretion (ADME) of Polyphenols
3. Toxicity Profile of Polyphenols
4. Autophagy and Neurodegenerative Diseases
4.1. Alzheimer’s Disease (AD)
4.2. Parkinson’s Disease (PD)
4.3. Huntington’s Disease (HD)
4.4. Amyotrophic Lateral Sclerosis (ALS)
4.5. Multiple Sclerosis (MS)
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
Aβ | Amyloid beta |
AD | Alzheimer’s disease |
AMPK | Adenosine monophosphate activated protein kinase |
ALS | Amyotrophic lateral sclerosis |
EGCG | Epigallocatechin-3 gallate |
EAE | Encephalomyelitis |
HD | Huntington’s disease |
LC3 1 and 2 | Microtubule-associated protein light chain |
mTOR | Mammalian target of rapamycin |
PD | Parkinson’s disease |
SNCA | Synuclein alpha |
SOD-1 | Superoxide dismutase-1 |
SIRT-1 | Sirtuin-1 |
TDP-43 | TAR DNA-binding protein-43 |
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Chandrasekaran, V.; Hediyal, T.A.; Anand, N.; Kendaganna, P.H.; Gorantla, V.R.; Mahalakshmi, A.M.; Ghanekar, R.K.; Yang, J.; Sakharkar, M.K.; Chidambaram, S.B. Polyphenols, Autophagy and Neurodegenerative Diseases: A Review. Biomolecules 2023, 13, 1196. https://doi.org/10.3390/biom13081196
Chandrasekaran V, Hediyal TA, Anand N, Kendaganna PH, Gorantla VR, Mahalakshmi AM, Ghanekar RK, Yang J, Sakharkar MK, Chidambaram SB. Polyphenols, Autophagy and Neurodegenerative Diseases: A Review. Biomolecules. 2023; 13(8):1196. https://doi.org/10.3390/biom13081196
Chicago/Turabian StyleChandrasekaran, Vichitra, Tousif Ahmed Hediyal, Nikhilesh Anand, Pavan Heggadadevanakote Kendaganna, Vasavi Rakesh Gorantla, Arehally M. Mahalakshmi, Ruchika Kaul Ghanekar, Jian Yang, Meena Kishore Sakharkar, and Saravana Babu Chidambaram. 2023. "Polyphenols, Autophagy and Neurodegenerative Diseases: A Review" Biomolecules 13, no. 8: 1196. https://doi.org/10.3390/biom13081196