The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis
Abstract
:1. Introduction
2. Resistance to Infection
2.1. Neutrophil Mediated Responses in Sepsis
2.2. Endothelial Dysfunction in Sepsis
2.3. The Cytokine Mediated Inflammatory Response in Sepsis
2.4. Switching Immune Cell Metabolism toward Glycolysis in Sepsis—The Warburg Effect
3. Tolerance to Infection
3.1. Iron Metabolism in the Pathogenesis of Sepsis
3.2. The Anti-Inflammatory Response in Sepsis
3.3. Hypoxia in the Pathogenesis of Sepsis
Number of Hyperbaric Sessions | ||||||||
---|---|---|---|---|---|---|---|---|
1–5 Sessions | 6–15 Sessions | 16–40 Sessions | ||||||
mRNA | Protein | DNA Signal | mRNA | Protein | mRNA | Protein | ||
Inflammatory stage | None | [113]*, [117]*, [118]*, [114] | [117]*, [118]*, [124], [125], [114], [17], [126] | [125], [114] | [124], [126] | |||
[115]* | ||||||||
Acute | [129], [130], [61]*, [131], [132], [133], [134], [135], | [61], | [136], [137], [139], | |||||
[116] | [171], [172], [140], [141] | [141]* | [120], [121] | [120], [144], [145], [146], [147], [156], [148]*, [157] | ||||
Chronic | [127]*, | [128], | ||||||
[119]* | [119]*, [138], | [122]*, | [122]*, | |||||
[142], [143] | [142] | [123] | [149], [151], [150], [152], [153] | [117] | [117], [154], [47], [155], [158], [159] | |||
(a) | ||||||||
Inflammatory stage | None | [117]* | [160], [17], [117] | |||||
Acute | [161], | [162], | ||||||
[163], [164], [165], [166], [46], [167] | [168] | [163], [169] | [163], [166], [169] | [166] | ||||
Chronic | [153], [170], [149] | [117] | [47], [154], [158], [117] | |||||
(b) |
4. Discussion
5. Future Directions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Vinkel, J.; Arenkiel, B.; Hyldegaard, O. The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis. Biomolecules 2023, 13, 1228. https://doi.org/10.3390/biom13081228
Vinkel J, Arenkiel B, Hyldegaard O. The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis. Biomolecules. 2023; 13(8):1228. https://doi.org/10.3390/biom13081228
Chicago/Turabian StyleVinkel, Julie, Bjoern Arenkiel, and Ole Hyldegaard. 2023. "The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis" Biomolecules 13, no. 8: 1228. https://doi.org/10.3390/biom13081228