Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate
Abstract
:1. Introduction
2. Structure and Binding Partners of API5
3. Physiological Functions of API5
3.1. Anti-Apoptotic Functions of API5
3.1.1. Inhibition of E2F1 (E2F Transcription Factor 1)-Induced Apoptosis
3.1.2. Inhibition of Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus)-Induced Apoptotic DNA Fragmentation
3.1.3. Inhibition of Caspase-2 Activation
3.1.4. Fibroblast Growth Factor Receptor 1 (FGFR1)/Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Signaling-Mediated Degradation of BIM
3.2. Cell Cycle Regulation Functions of API5
3.3. mRNA Export Functions of API5
3.4. Modulation of TLR4 Signaling in Dendritic Cells and Adjuvant Effect of API5
3.5. Paneth Cell Protective Action of API5 as a Putative Therapeutic Target for Crohn’s Disease
3.6. Enhancement of Viral Replication by API5
4. API5 and Cancer
4.1. API5 Expression and Prognosis Value
4.2. API5’s Role on Cancer Metastasis, Immune Response, and Survival
4.3. Targeting API5 as a Therapeutic Approach
5. Conclusions and Future Directions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Protein | Gene Name | Biological Impact | Reference |
---|---|---|---|
Fibroblast growth factor 2 | FGF2 | Modulation of mRNA nuclear export | [47,48] |
Apoptotic chromatin condensation inducer in the nucleus | ACIN1 | Regulation of apoptotic DNA fragmentation | [48] |
Amplified in liver cancer 1 | ALC1 | Not determined | [49] |
Nucleoprotein of influenza A virus | NP | Stimulation of E2F1- mediated apoptosis | [50] |
Caspase-2 | CASP2 | Inhibition of caspase-2 activation | [51] |
Estrogen receptor α | ERα | Gene expression regulation | [26] |
Toll-like receptor 4 | TLR4 | Modulation of TLR4 signaling (agonist effect) | [52] |
Leucine-rich pentatricopeptide repeat containing | LRPPRC | Modulation of mRNA nuclear export | [47] |
U2AF65-associated protein 56 | UAP56 | Modulation of mRNA nuclear export | [47] |
P300 | P300 | Regulation of API5 stability | [53] |
Histone deacetylase 1 | HDAC1 | Regulation of API5 stability | [53] |
p21-activated kinase 1 | PAK1 | Not determined | [54] |
VP3 protein of Avibirnavirus | VP3 | Regulation of API5 SUMOylation | [55] |
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Abbas, H.; Derkaoui, D.K.; Jeammet, L.; Adicéam, E.; Tiollier, J.; Sicard, H.; Braun, T.; Poyet, J.-L. Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate. Biomolecules 2024, 14, 136. https://doi.org/10.3390/biom14010136
Abbas H, Derkaoui DK, Jeammet L, Adicéam E, Tiollier J, Sicard H, Braun T, Poyet J-L. Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate. Biomolecules. 2024; 14(1):136. https://doi.org/10.3390/biom14010136
Chicago/Turabian StyleAbbas, Hafsia, Dalia Kheira Derkaoui, Louise Jeammet, Emilie Adicéam, Jérôme Tiollier, Hélène Sicard, Thorsten Braun, and Jean-Luc Poyet. 2024. "Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate" Biomolecules 14, no. 1: 136. https://doi.org/10.3390/biom14010136