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Volume 14
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Review

Cellular Senescence: A Bridge Between Diabetes and Microangiopathy

by
Jiahui Liu
1,†,
Buyu Guo
1,†,
Qianqian Liu
1,
Guomao Zhu
1,
Yaqi Wang
1,
Na Wang
1,
Yichen Yang
1 and
Songbo Fu
2,3,*
1
The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China
2
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou 730000, China
3
Gansu Province Clinical Research Center for Endocrine Disease, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2024, 14(11), 1361; https://doi.org/10.3390/biom14111361
Submission received: 28 August 2024 / Revised: 21 October 2024 / Accepted: 24 October 2024 / Published: 25 October 2024
(This article belongs to the Special Issue DNA Damage, Mutagenesis, and Repair Mechanisms)
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Abstract

Cellular senescence is a state of permanent cell cycle arrest and plays an important role in many vascular lesions. This study found that the cells of diabetic patients have more characteristics of senescence, which may cause microvascular complications. Cell senescence, as one of the common fates of cells, links microangiopathy and diabetes. Cell senescence in a high-glucose environment can partially elucidate the mechanism of diabetic microangiopathy, and various types of cellular senescence induced by it can promote the progression of diabetic microangiopathy. Still, the molecular mechanism of microangiopathy-related cellular senescence has not yet been clearly studied. Building on recent research evidence, we herein summarize the fundamental mechanisms underlying the development of cellular senescence in various microangiopathies associated with diabetes. We gradually explain how cellular senescence serves as a key driver of diabetic microangiopathy. At the same time, the treatment of basic senescence mechanisms such as cellular senescence may have a great impact on the pathogenesis of the disease, may be more effective in preventing the development of diabetic microangiopathy, and may provide new ideas for the clinical treatment and prognosis of diabetic microangiopathy.
Keywords: cellular senescence; diabetes mellitus; microvascular complications; diabetic retinopathy; diabetic nephropathy; diabetic cardiomyopathy cellular senescence; diabetes mellitus; microvascular complications; diabetic retinopathy; diabetic nephropathy; diabetic cardiomyopathy

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MDPI and ACS Style

Liu, J.; Guo, B.; Liu, Q.; Zhu, G.; Wang, Y.; Wang, N.; Yang, Y.; Fu, S. Cellular Senescence: A Bridge Between Diabetes and Microangiopathy. Biomolecules 2024, 14, 1361. https://doi.org/10.3390/biom14111361

AMA Style

Liu J, Guo B, Liu Q, Zhu G, Wang Y, Wang N, Yang Y, Fu S. Cellular Senescence: A Bridge Between Diabetes and Microangiopathy. Biomolecules. 2024; 14(11):1361. https://doi.org/10.3390/biom14111361

Chicago/Turabian Style

Liu, Jiahui, Buyu Guo, Qianqian Liu, Guomao Zhu, Yaqi Wang, Na Wang, Yichen Yang, and Songbo Fu. 2024. "Cellular Senescence: A Bridge Between Diabetes and Microangiopathy" Biomolecules 14, no. 11: 1361. https://doi.org/10.3390/biom14111361

APA Style

Liu, J., Guo, B., Liu, Q., Zhu, G., Wang, Y., Wang, N., Yang, Y., & Fu, S. (2024). Cellular Senescence: A Bridge Between Diabetes and Microangiopathy. Biomolecules, 14(11), 1361. https://doi.org/10.3390/biom14111361

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