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Article

The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

by
Gabriel Simonetti da Silva
,
Maria Beatriz Braghetto Hernandes
and
José Carlos Toledo Junior
*
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, SP, Brazil
*
Author to whom correspondence should be addressed.
Biomolecules 2024, 14(7), 871; https://doi.org/10.3390/biom14070871
Submission received: 5 June 2024 / Revised: 3 July 2024 / Accepted: 9 July 2024 / Published: 19 July 2024
(This article belongs to the Section Chemical Biology)

Abstract

Although the labile iron pool (LIP) biochemical identity remains a topic of debate, it serves as a universal homeostatically regulated and essential cellular iron source. The LIP plays crucial cellular roles, being the source of iron that is loaded into nascent apo-iron proteins, a process akin to protein post-translational modification, and implicated in the programmed cell death mechanism known as ferroptosis. The LIP is also recognized for its reactivity with chelators, nitric oxide, and peroxides. Our recent investigations in a macrophage cell line revealed a reaction of the LIP with the oxidant peroxynitrite. In contrast to the LIP’s pro-oxidant interaction with hydrogen peroxide, this reaction is rapid and attenuates the peroxynitrite oxidative impact. In this study, we demonstrate the existence and antioxidant characteristic of the LIP and peroxynitrite reaction in various cell types. Beyond its potential role as a ubiquitous complementary or substitute protection system against peroxynitrite for cells, the LIP and peroxynitrite reaction may influence cellular iron homeostasis and ferroptosis by changing the LIP redox state and LIP binding properties and reactivity.
Keywords: labile iron pool; labile iron; LIP; chelatable iron pool; CIP; iron; peroxynitrite; nitric oxide; superoxide labile iron pool; labile iron; LIP; chelatable iron pool; CIP; iron; peroxynitrite; nitric oxide; superoxide

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MDPI and ACS Style

da Silva, G.S.; Hernandes, M.B.B.; Toledo Junior, J.C. The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly. Biomolecules 2024, 14, 871. https://doi.org/10.3390/biom14070871

AMA Style

da Silva GS, Hernandes MBB, Toledo Junior JC. The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly. Biomolecules. 2024; 14(7):871. https://doi.org/10.3390/biom14070871

Chicago/Turabian Style

da Silva, Gabriel Simonetti, Maria Beatriz Braghetto Hernandes, and José Carlos Toledo Junior. 2024. "The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly" Biomolecules 14, no. 7: 871. https://doi.org/10.3390/biom14070871

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