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Volume 14
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10.3390/biom14080940
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Review

Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging

by
Maima Matin
1,
Tanuj Joshi
2,
Dongdong Wang
3,
Nikolay T. Tzvetkov
4,
Farhan Bin Matin
5,
Agnieszka Wierzbicka
1,
Artur Jóźwik
1,
Jarosław Olav Horbańczuk
1 and
Atanas G. Atanasov
1,6,7,*
1
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland
2
Department of Pharmaceutical Sciences, Bhimtal, Kumaun University, Nainital 263002, India
3
Centre for Metabolism, Obesity and Diabetes Research, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
4
Department of Biochemical Pharmacology and Drug Design, Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
5
Department of Pharmacy, East West University, Aftabnagar, Dhaka 1212, Bangladesh
6
Laboratory of Natural Products and Medicinal Chemistry (LNPMC), Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105, India
7
Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Biomolecules 2024, 14(8), 940; https://doi.org/10.3390/biom14080940
Submission received: 12 June 2024 / Revised: 22 July 2024 / Accepted: 29 July 2024 / Published: 2 August 2024
(This article belongs to the Special Issue Therapeutic Potential of Natural Products in Metabolic Diseases)
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Abstract

Ginger (Zingiber officinale Roscoe) is broadly used as a traditional remedy and food ingredient, and numerous preclinical and clinical studies have demonstrated health benefits in a range of age-related disorders. Moreover, longevity-promoting effects have been demonstrated in several (preclinical) research models. With this work, we aimed to comprehensively review the reported effects of ginger and its bioactive constituents on the twelve established hallmarks of aging, with the ultimate goal of gaining a deeper understanding of the potential for future interventions in the area of longevity-extension and counteracting of aging-related diseases. The reviewed literature supports the favorable effects of ginger and some of its constituents on all twelve hallmarks of aging, with a particularly high number of animal research studies indicating counteraction of nutrient-sensing dysregulations, mitochondrial dysfunction, chronic inflammation, and dysbiosis. On this background, validation in human clinical trials is still insufficient or is entirely missing, with the exception of some studies indicating positive effects on deregulated nutrient-sensing, chronic inflammation, and dysbiosis. Thus, the existing body of literature clearly supports the potential of ginger to be further studied in clinical trials as a supplement for the promotion of both lifespan and health span.
Keywords: ginger; hallmarks of aging; longevity; life-extension; lifespan; health span; metabolism; inflammation ginger; hallmarks of aging; longevity; life-extension; lifespan; health span; metabolism; inflammation

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MDPI and ACS Style

Matin, M.; Joshi, T.; Wang, D.; Tzvetkov, N.T.; Matin, F.B.; Wierzbicka, A.; Jóźwik, A.; Horbańczuk, J.O.; Atanasov, A.G. Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging. Biomolecules 2024, 14, 940. https://doi.org/10.3390/biom14080940

AMA Style

Matin M, Joshi T, Wang D, Tzvetkov NT, Matin FB, Wierzbicka A, Jóźwik A, Horbańczuk JO, Atanasov AG. Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging. Biomolecules. 2024; 14(8):940. https://doi.org/10.3390/biom14080940

Chicago/Turabian Style

Matin, Maima, Tanuj Joshi, Dongdong Wang, Nikolay T. Tzvetkov, Farhan Bin Matin, Agnieszka Wierzbicka, Artur Jóźwik, Jarosław Olav Horbańczuk, and Atanas G. Atanasov. 2024. "Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging" Biomolecules 14, no. 8: 940. https://doi.org/10.3390/biom14080940

APA Style

Matin, M., Joshi, T., Wang, D., Tzvetkov, N. T., Matin, F. B., Wierzbicka, A., Jóźwik, A., Horbańczuk, J. O., & Atanasov, A. G. (2024). Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging. Biomolecules, 14(8), 940. https://doi.org/10.3390/biom14080940

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