Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome?
Abstract
:1. Introduction
2. Discussions
3. Conclusions
Acknowledgments
Conflicts of Interest
References
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Key Genes | Gene Function |
---|---|
AGPAT2 | AGPAT2 catalyzes formation of phosphatidic acid. |
AKT2 | AKT2, also known as protein kinase B. Involved in adipocyte differentiation. Downstream insulin receptor signaling. |
CAV1 | Caveolin 1 binds and transports fatty acids to lipid droplets. |
LMNA | Lamins A and C are nuclear lamina proteins linked with the cytoskeleton. |
PLIN1 | Perilipin 1 is an essential component for lipid storage. |
PPAR-γ | PPARG is crucial for adipogenesis and for maintenance of the differentiation phase. |
PTRF | Creates caveolae and regulates expression of caveolins 1 and 3. |
ZMPSTE24 | A zinc metalloproteinase involved in the correct processing and maturation of lamin A (LMNA). |
CIDEC | A cell death-inducing DNA fragmentation factor-like effector family with important roles in apoptosis, regulated by insulin and its expression is positively correlated with insulin sensitivity. |
PSMB8 | A proteasome subunit beta type-8 as known as 20S proteasome shapes the antigenic repertoire presented on major histocompatibility complex (MHC) class I molecules. |
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Mathur, S.K.; Tiwari, P.; Gupta, S.; Gupta, N.; Nimesh, S.; Medicherla, K.M.; Suravajhala, P. Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome? Biomolecules 2018, 8, 47. https://doi.org/10.3390/biom8030047
Mathur SK, Tiwari P, Gupta S, Gupta N, Nimesh S, Medicherla KM, Suravajhala P. Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome? Biomolecules. 2018; 8(3):47. https://doi.org/10.3390/biom8030047
Chicago/Turabian StyleMathur, Sandeep Kumar, Pradeep Tiwari, Sonal Gupta, Nidhi Gupta, Surendra Nimesh, Krishna Mohan Medicherla, and Prashanth Suravajhala. 2018. "Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome?" Biomolecules 8, no. 3: 47. https://doi.org/10.3390/biom8030047