Developments in Cell-Penetrating Peptides as Antiviral Agents and as Vehicles for Delivery of Peptide Nucleic Acid Targeting Hepadnaviral Replication Pathway
Abstract
:1. Introduction
2. Why Cell Penetrating Peptides Are of Particular Interest for Delivery of Bioactive Molecules
3. Antiviral Activity of Cell Penetrating Peptides Altering Hepadnaviral Replication
4. Anti-Duck Hepatitis B Virus Effect of Peptide Nucleic Acids coupled to Cell Penetrating Peptides Conjugates
5. Sugar Modified CPP-PNA Uptake and Their Anti-HBV Activity in HepaRG Cells
6. Antiviral Activity of CPP-Based Approaches against Other Viruses
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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CPPs | Cell or Animal Models | Target | % D’inhibition | Toxicity |
---|---|---|---|---|
(DArg)8 | PDHs | DHBV | 44–60% (2 μM) | [10,23] |
Pekin ducklings | DHBV | 42% (1 μg/g/bw/day) | – [10] | |
Decanoyl(DArg)8 | PDHs | DHBV | 86–90% (2 μM) | – [23] |
LMH-D2 | DHBV | 88–90% (2 μM) | – [23] | |
HepG2.2.15 | HBV | 50% (4 μM) | – [23] | |
(DArg)8-PNA | PDHs | DHBV Epsilon (ε) | 47–59% (2 μM) | – [10] |
Pekin ducklings | DHBV Epsilon (ε) | 49–59% (1 μg/g/bw/day) | – [10] |
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Ndeboko, B.; Hantz, O.; Lemamy, G.J.; Cova, L. Developments in Cell-Penetrating Peptides as Antiviral Agents and as Vehicles for Delivery of Peptide Nucleic Acid Targeting Hepadnaviral Replication Pathway. Biomolecules 2018, 8, 55. https://doi.org/10.3390/biom8030055
Ndeboko B, Hantz O, Lemamy GJ, Cova L. Developments in Cell-Penetrating Peptides as Antiviral Agents and as Vehicles for Delivery of Peptide Nucleic Acid Targeting Hepadnaviral Replication Pathway. Biomolecules. 2018; 8(3):55. https://doi.org/10.3390/biom8030055
Chicago/Turabian StyleNdeboko, Bénédicte, Olivier Hantz, Guy Joseph Lemamy, and Lucyna Cova. 2018. "Developments in Cell-Penetrating Peptides as Antiviral Agents and as Vehicles for Delivery of Peptide Nucleic Acid Targeting Hepadnaviral Replication Pathway" Biomolecules 8, no. 3: 55. https://doi.org/10.3390/biom8030055