Comparison of Secular Trends in Peptic Ulcer Diseases Mortality in China, Brazil and India during 1990–2019: An Age-Period-Cohort Analysis
, Lihong Huang 1,†, Ruiqing Li 1, Tong Wang 1, Shuwen Wang 1, Chuanhua Yu 1,2,* and Jie Gong 1,3,*
Round 1
Reviewer 1 Report
The article is very interesting on the subject and is well structured and has a well organized progression. The figures are accurate. I would say that a tab is needed on the discussion with the risk factors found in comparison of the countries studied.
Author Response
Thank you very much for your revision, please see the attachment for the detailed reply.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
1. Could the author interpret the data? Why and how China, Brazil, and India have an inspiring decline in ASMR of PUD.
2. The inclusion and exclusion criteria are not clear.
3. The discussion section is poor. The author has to explain the previous study and discuss that.
4. I suggest the author make a table and describe the results.
5. What is the home message of the study.
6. What is the future study.
Author Response
Thank you very much for your revision, please see the attachment for the detailed reply.
Author Response File: Author Response.pdf
Reviewer 3 Report
Please see the attachment
Comments for author File: Comments.pdf
Author Response
Thank you very much for your revision, please see the attachment for the detailed reply.
Author Response File: Author Response.pdf
Reviewer 4 Report
Existing papers have evaluated the incidence of PUD in various countries. It is not clear why this study was conducted in India, Brazil, and China.
A further result of this study is that they focused on Smoking and added more assessments.
However, the relationship between smoking and PUDs, which is the subject of this paper, has been pointed out in the past.
A more detailed evaluation of smoking and eradication　seems necessary.
Author Response
Thank you very much for your revision, please see the attachment for the detailed reply.
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
Thank you
Author Response
Thank you for your suggestions. We have consulted experts to polish our manuscript and made revisions according to the suggestions of you and other reviewers. Please see the revised manuscript for specific changes.
Reviewer 4 Report
In your paper's concluding paragraph, isn't it an overstatement to say that smoking policies reduced PUD?
Author Response
Thank you for your suggestions. We have consulted experts to polish our manuscript and made revisions according to the suggestions of you and other reviewers. Please see the attachment for detailed reply content.
Author Response File: Author Response.pdf
