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Article

Natural History of Scoliosis in Children with NF1: An Observation Study

by
Giuseppe Toro
1,2,
Claudia Santoro
3,4,
Daniele Ambrosio
1,
Giovanni Landi
1,
Martina Scilipoti
3,
Antimo Moretti
1,
Marco Paoletta
1,*,
Sara Liguori
1,
Alfredo Schiavone Panni
1,
Stefania Picariello
3 and
Giovanni Iolascon
1
1
Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
2
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
3
Department of Woman, Child and of General and Specialised Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
4
Department of Mental Health, Physical and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Healthcare 2021, 9(7), 881; https://doi.org/10.3390/healthcare9070881
Submission received: 27 April 2021 / Revised: 25 June 2021 / Accepted: 9 July 2021 / Published: 13 July 2021
(This article belongs to the Special Issue Vertebral Related Diseases in Healthcare: The Role of Pain Management and Rehabilitation)
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Abstract

(1) Background. Scoliosis is the most common musculoskeletal manifestation of Neurofibromatosis type 1 (NF1), and it might be dystrophic (D) or non-dystrophic (ND) depending on the presence of dysplastic changes of the spine. The aim of our study was to describe the characteristics and natural history of patients with NF1 and scoliosis. (2) Methods. We retrospectively reviewed records from patients with NF1 and scoliosis. Scoliosis was classified as D if at least two dystrophic changes were documented at imaging. (3) Results. Of the 438 patients reviewed, 43 fulfilled inclusion criteria; 17 were classified in D group and 26 in ND. The groups did not differ in age and localization of scoliosis curvature. Surgery was needed more often in D group, but the between-group difference was not significant. Male-to-female ratios of 3:1 and 4:1 were reported in surgically treated NF1 patients with ND and D scoliosis, respectively. (4) Conclusions. Our data suggests independently by the presence of dysplastic changes affecting the spine that males with NF1 are more often affected by scoliosis that requires surgery.
Keywords: neurofibromatosis type 1; scoliosis; treatment; natural history; dystrophic; non-dystrophic neurofibromatosis type 1; scoliosis; treatment; natural history; dystrophic; non-dystrophic

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MDPI and ACS Style

Toro, G.; Santoro, C.; Ambrosio, D.; Landi, G.; Scilipoti, M.; Moretti, A.; Paoletta, M.; Liguori, S.; Schiavone Panni, A.; Picariello, S.; et al. Natural History of Scoliosis in Children with NF1: An Observation Study. Healthcare 2021, 9, 881. https://doi.org/10.3390/healthcare9070881

AMA Style

Toro G, Santoro C, Ambrosio D, Landi G, Scilipoti M, Moretti A, Paoletta M, Liguori S, Schiavone Panni A, Picariello S, et al. Natural History of Scoliosis in Children with NF1: An Observation Study. Healthcare. 2021; 9(7):881. https://doi.org/10.3390/healthcare9070881

Chicago/Turabian Style

Toro, Giuseppe, Claudia Santoro, Daniele Ambrosio, Giovanni Landi, Martina Scilipoti, Antimo Moretti, Marco Paoletta, Sara Liguori, Alfredo Schiavone Panni, Stefania Picariello, and et al. 2021. "Natural History of Scoliosis in Children with NF1: An Observation Study" Healthcare 9, no. 7: 881. https://doi.org/10.3390/healthcare9070881

APA Style

Toro, G., Santoro, C., Ambrosio, D., Landi, G., Scilipoti, M., Moretti, A., Paoletta, M., Liguori, S., Schiavone Panni, A., Picariello, S., & Iolascon, G. (2021). Natural History of Scoliosis in Children with NF1: An Observation Study. Healthcare, 9(7), 881. https://doi.org/10.3390/healthcare9070881

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