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Volume 10
Issue 11
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Article

Levels of TNF-α and Soluble TNF Receptors in Normal-Weight, Overweight and Obese Patients with Dilated Non-Ischemic Cardiomyopathy: Does Anti-TNF Therapy Still Have Potential to Be Used in Heart Failure Depending on BMI?

by
Elżbieta Lazar-Poloczek
1,*,
Ewa Romuk
2,
Wojciech Jacheć
1,
Wiktoria Stanek
3,
Bartosz Stanek
3,
Monika Szołtysik
3,
Tomasz Techmański
3,
Maja Hasterok
3 and
Celina Wojciechowska
1
1
Second Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, M. C. Skłodowskiej 10 Street, 41-800 Zabrze, Poland
2
Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 Street, 41-808 Zabrze, Poland
3
Student Research Team at the Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 Street, 41-800 Zabrze, Poland
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(11), 2959; https://doi.org/10.3390/biomedicines10112959
Submission received: 30 September 2022 / Revised: 7 November 2022 / Accepted: 14 November 2022 / Published: 17 November 2022
(This article belongs to the Special Issue Advances in Therapy for Heart Failure)
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Abstract

Background. We sought to measure the levels of adipokines, TNF-α and soluble receptors (sTNFr1, sTNFr2) in heart failure patients with reduced ejection fraction (HFrEF) due to non-ischemic cardiomyopathy (nDCM). Methods. A total of 123 patients with HFrEF due to nDCM were divided into three groups according to BMI: 34 (27.6%) normal weight, 56 (45.5%) overweight and 33 (26.8%) obese. A six-minute walk test, echocardiography and right heart catheterization were performed. Serum concentrations of adiponectin, leptin, NT-proBNP, blood hemoglobin, sodium, creatinine, ALAT, AspAT, bilirubin, CRP, lipids, TNF-α, sTNFr1 and sTNFr2 receptors were measured. Results. Obese patients had the lowest NT-proBNP concentrations, significantly higher leptin levels and higher leptin/adiponectin ratios. The concentration of sTNFr1 was higher in normal-weight patients. In all groups, TNF-α concentrations correlated positively with sTNFr1 (p < 0.001). Higher levels of sTNFr1 were associated with higher sTNFr2 (p < 0.001) and CRP (p < 0.001). Moreover, the concentration of sTNFr2 positively correlated with CRP (p < 0.05) and adiponectin (p < 0.001). Levels of TNF-α were not associated with elevated CRP. Conclusion: This study demonstrated that changes in the concentrations of TNF and its receptors differ between groups of patients with different BMI. These findings suggest that the effective use of anti-TNF therapy is dependent not only on BMI, but also on concentrations of TNF-α receptors and other laboratory parameters.
Keywords: heart failure; tumor necrosis factor alpha; adipokines; obesity heart failure; tumor necrosis factor alpha; adipokines; obesity

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MDPI and ACS Style

Lazar-Poloczek, E.; Romuk, E.; Jacheć, W.; Stanek, W.; Stanek, B.; Szołtysik, M.; Techmański, T.; Hasterok, M.; Wojciechowska, C. Levels of TNF-α and Soluble TNF Receptors in Normal-Weight, Overweight and Obese Patients with Dilated Non-Ischemic Cardiomyopathy: Does Anti-TNF Therapy Still Have Potential to Be Used in Heart Failure Depending on BMI? Biomedicines 2022, 10, 2959. https://doi.org/10.3390/biomedicines10112959

AMA Style

Lazar-Poloczek E, Romuk E, Jacheć W, Stanek W, Stanek B, Szołtysik M, Techmański T, Hasterok M, Wojciechowska C. Levels of TNF-α and Soluble TNF Receptors in Normal-Weight, Overweight and Obese Patients with Dilated Non-Ischemic Cardiomyopathy: Does Anti-TNF Therapy Still Have Potential to Be Used in Heart Failure Depending on BMI? Biomedicines. 2022; 10(11):2959. https://doi.org/10.3390/biomedicines10112959

Chicago/Turabian Style

Lazar-Poloczek, Elżbieta, Ewa Romuk, Wojciech Jacheć, Wiktoria Stanek, Bartosz Stanek, Monika Szołtysik, Tomasz Techmański, Maja Hasterok, and Celina Wojciechowska. 2022. "Levels of TNF-α and Soluble TNF Receptors in Normal-Weight, Overweight and Obese Patients with Dilated Non-Ischemic Cardiomyopathy: Does Anti-TNF Therapy Still Have Potential to Be Used in Heart Failure Depending on BMI?" Biomedicines 10, no. 11: 2959. https://doi.org/10.3390/biomedicines10112959

APA Style

Lazar-Poloczek, E., Romuk, E., Jacheć, W., Stanek, W., Stanek, B., Szołtysik, M., Techmański, T., Hasterok, M., & Wojciechowska, C. (2022). Levels of TNF-α and Soluble TNF Receptors in Normal-Weight, Overweight and Obese Patients with Dilated Non-Ischemic Cardiomyopathy: Does Anti-TNF Therapy Still Have Potential to Be Used in Heart Failure Depending on BMI? Biomedicines, 10(11), 2959. https://doi.org/10.3390/biomedicines10112959

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