Urine Oxidative Stress Biomarkers as Novel Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome
, Jia-Fong Jhang 1,2, Han-Chen Ho 3, Dan-Yun Chiou 1 and Hann-Chorng Kuo 1,2,*Round 1
Reviewer 1 Report
The manuscript entitled “Urine Oxidative Stress Biomarkers as Novel Biomarkers in Interstitial Cystitis/ Bladder Pain Syndrome” is a clinical study to investigate the role of oxidative stress biomarkers in patients with interstitial cystitis/bladder pain syndrome. The clinical study is well designed. The conclusions and limitations of the study are adequately addressed.
The manuscript is recommended for publication in the Biomedicines after minor revision.
Please consider the following suggestions and corrections:
Lines 3, 24, 44: Do not leave a space around /: cystitis/bladder
Line 46 and throughout the text: In the text, reference numbers should be placed in square brackets [ ], and placed before the punctuation; for example [1], [1–3] or [1,3].
Lines 59-60: an important role instead of important an role
Line 87: European Society for the Study of Interstitial Cystitis 92 (ESSIC) instead of ESSIC
Line 92: ESSIC instead of European Society for the Study of Interstitial Cystitis 92 (ESSIC)
Line 124: add City, Country after Enzo
Line 125: add City, Country after Abcam
Line 164, Table 1: Leave a space before and after mathematical operators that function as verbs or conjunctions; that is, they have numbers on both sides or a symbol for a variable on one side and a number on the other. E. g., N = 42; 56.9 ± 10.9; MBC ≧ 760 mL
mL instead of ml.
Adjust the table format as in the template. Check the Journal Instructions for Authors for more details. Do the same for tables 2, 3, 4, 5, and 6.
Lines 165-169: Customise a table footer as in the template.
Lines 213-216: This is still a brief description of the picture and should be continued in line 212. Do not put in bold.
Line 237: odds ratio (OR) instead of OR
Line 245: add CI, confidence interval.
Line 268: role instead of roles
Line 358: Manuscript must contain the required sections: Funding Information, Author Contributions, Conflict of Interest and other Ethics Statements. Check the Journal Instructions for Authors for more details.
Lines 359 – 363: Match font: Palatino Linotype, size: 9
Author Response
Reviewer 1
The manuscript entitled “Urine Oxidative Stress Biomarkers as Novel Biomarkers in Interstitial Cystitis/ Bladder Pain Syndrome” is a clinical study to investigate the role of oxidative stress biomarkers in patients with interstitial cystitis/bladder pain syndrome. The clinical study is well designed. The conclusions and limitations of the study are adequately addressed.
The manuscript is recommended for publication in the Biomedicines after minor revision.
Please consider the following suggestions and corrections:
Lines 3, 24, 44: Do not leave a space around /: cystitis/bladder
Reply: Thank you for the comment. We have revised all of these accordingly. (see Line 3, 24, 44)
Line 46 and throughout the text: In the text, reference numbers should be placed in square brackets [ ], and placed before the punctuation; for example [1], [1–3] or [1,3].
Reply: Thank you for the comment. We have revised the form of reference number.
Lines 59-60: an important role instead of important an role
Reply: Thank you for the comment. We have revised it. (Line 59-60)
Line 87: European Society for the Study of Interstitial Cystitis 92 (ESSIC) instead of ESSIC
Reply: Thank you for the comment. We have revised it. (Line 88-89)
Line 92: ESSIC instead of European Society for the Study of Interstitial Cystitis 92 (ESSIC)
Reply: Thank you for the comment. We have revised it. (Line 94)
Line 124: add City, Country after Enzo
Reply: Thank you for the comment. We have added the city and country (Farmingdale, NY, USA). (Line 125-126)
Line 125: add City, Country after Abcam
Reply: Thank you for the comment. We have added the city and country (Cambridge, MA, USA). (Line 126)
Line 164, Table 1: Leave a space before and after mathematical operators that function as verbs or conjunctions; that is, they have numbers on both sides or a symbol for a variable on one side and a number on the other. E. g., N = 42; 56.9 ± 10.9; MBC ≧ 760 mL
mL instead of ml.
Reply: Thank you for the comment. We have revised them accordingly. (Table 1-6)
Adjust the table format as in the template. Check the Journal Instructions for Authors for more details. Do the same for tables 2, 3, 4, 5, and 6.
Reply: Thank you for the comment. We have revised them accordingly. (Table 1-6)
Lines 165-169: Customise a table footer as in the template.
Reply: Thank you for the comment. We have revised it. (Line 167-171)
Lines 213-216: This is still a brief description of the picture and should be continued in line 212. Do not put in bold.
Reply: Thank you for the comment. We have revised the description accordingly. (Line 213-216)
Line 237: odds ratio (OR) instead of OR
Reply: Thank you for the comment. We have revised it accordingly. (Line 237)
Line 245: add CI, confidence interval.
Reply: Thank you for the comment. We have revised it accordingly. (Line 244-245, Table 5)
Line 268: role instead of roles
Reply: Thank you for the comment. We have revised it accordingly. (Line 268)
Line 358: Manuscript must contain the required sections: Funding Information, Author Contributions, Conflict of Interest and other Ethics Statements. Check the Journal Instructions for Authors for more details.
Reply: Thank you for the comment. We have added the required sections accordingly. (Line 359-379)
Lines 359 – 363: Match font: Palatino Linotype, size: 9
Reply: Thank you for the comment. We have revised it accordingly. (Line 359-361)
Reviewer 2 Report
The authors presented a clinical study on the oxidative stress biomarkers as a diagnostic tool for interstitial cystitis/ bladder pain syndrome.
The manuscript is well written, clear and well organized.
This study seem highly relevant in the field and I do believe that it is ready for publication.
Only minor corrections are necessary, as below:
Line 59 - "...to have important an role..." should be "to have an important role"
Author Response
Reviewer 2
The authors presented a clinical study on the oxidative stress biomarkers as a diagnostic tool for interstitial cystitis/ bladder pain syndrome.
The manuscript is well written, clear and well organized.
This study seem highly relevant in the field and I do believe that it is ready for publication.
Only minor corrections are necessary, as below:
Line 59 - "...to have important an role..." should be "to have an important role"
Reply: Thank you for the comment. We have revised it accordingly. (Line 60)
