Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder
Abstract
:1. Introduction
1.1. Major Depressive Disorder (MDD)
1.2. A Genetic Perspective on Major Depressive Disorder
1.3. Implication of miRNA in Major Depressive Disorder
1.4. Pathogenic Mechanisms of miRNA in Major Depressive Disorder
2. Materials and Methods
2.1. Study Sample and Design
2.2. Profiling of miRNAs
2.3. Statistical Analysis
2.4. Bioinformatic Analysis and Identification of the Relationships between miRNAs and Potential Pathways from MDD
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Number | miRNA ID | Fold Regulation | p-Value |
---|---|---|---|
1 | hsa-miR-874-3p | 19.4 | 0.013566 |
2 | hsa-miR-574-3p | 6.01 | 0.019013 |
3 | hsa-miR-451a | 1.86 | 0.019841 |
4 | hsa-miR-93-3p | 8.47 | 0.020517 |
5 | hsa-let-7d-5p | 13.45 | 0.021807 |
6 | hsa-miR-125a-5p | 2.59 | 0.022523 |
7 | hsa-miR-132-3p | 3.76 | 0.026436 |
8 | hsa-miR-141-3p | 3.19 | 0.033533 |
9 | hsa-miR-140-5p | 4.8 | 0.03412 |
10 | hsa-miR-376a-3p | 2.45 | 0.042657 |
11 | hsa-miR-423-3p | 2.1 | 0.04844 |
Index | Name | p-Value | Adjusted p-Value | Odds Ratio | Combined Score |
---|---|---|---|---|---|
1 | Thyroid hormone signaling pathway | 0.006023 | 0.1782 | 8.69 | 44.42 |
2 | Pathways of neurodegeneration | 0.01480 | 0.2182 | 3.70 | 15.58 |
3 | Arachidonic acid metabolism | 0.01492 | 0.2182 | 11.42 | 48.03 |
4 | Prolactin signaling pathway | 0.01935 | 0.2441 | 9.91 | 39.08 |
5 | Transcriptional misregulation in cancer | 0.02086 | 0.2441 | 5.41 | 20.92 |
6 | Alzheimer disease | 0.02611 | 0.2777 | 3.76 | 13.72 |
7 | Serotonergic synapse | 0.04666 | 0.3211 | 6.06 | 18.56 |
Index | Name | p-Value | Adjusted p-Value | Odds Ratio | Combined Score |
---|---|---|---|---|---|
1 | Hedgehog signaling pathway | 0.01151 | 0.5293 | 13.15 | 58.72 |
2 | Maturity-onset diabetes of the young | 0.07277 | 0.5293 | 13.98 | 36.63 |
3 | Cellular senescence | 0.07528 | 0.5293 | 4.59 | 11.87 |
4 | Axon guidance | 0.09785 | 0.5293 | 3.92 | 9.11 |
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Prodan-Bărbulescu, C.; Alin, C.D.; Faur, I.F.; Bujor, G.C.; Şeclăman, E.P.; Enătescu, V.; Dănilă, A.-I.; Dăescu, E.; Hajjar, R.; Ghenciu, L.A.; et al. Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder. Biomedicines 2024, 12, 2165. https://doi.org/10.3390/biomedicines12102165
Prodan-Bărbulescu C, Alin CD, Faur IF, Bujor GC, Şeclăman EP, Enătescu V, Dănilă A-I, Dăescu E, Hajjar R, Ghenciu LA, et al. Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder. Biomedicines. 2024; 12(10):2165. https://doi.org/10.3390/biomedicines12102165
Chicago/Turabian StyleProdan-Bărbulescu, Cătălin, Cristian Daniel Alin, Ionuţ Flaviu Faur, Georgeta Cristiana Bujor, Edward Paul Şeclăman, Virgil Enătescu, Alexandra-Ioana Dănilă, Ecaterina Dăescu, Rami Hajjar, Laura Andreea Ghenciu, and et al. 2024. "Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder" Biomedicines 12, no. 10: 2165. https://doi.org/10.3390/biomedicines12102165