Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical Differences
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Children with Short Stature (n = 277) | Children with GH Peak <10 ng/mL (n = 138) | Children with GH Peak ≥10 ng/mL (n = 139) | |||||||
---|---|---|---|---|---|---|---|---|---|
All | Boys | Girls | All | Boys | Girls | All | Boys | Girls | |
Number | 277 | 181 | 96 | 138 | 88 | 50 | 139 | 93 | 46 |
Gender [%] | - | 65.34% | 34.66% | - | 63.8% | 36.2% | - | 66.9% | 33.1% |
Bone age delay [years] | −1.50 ± 0.93 | −1.56 ± 0.95 | −1.38 ± 0.87 | −1.54 ± 0.89 | −1.55 ± 0.85 | −1.50 ± 0.96 | −1.47 ± 0.96 | −1.56 ± 1.03 | −1.23 ± 0.76 |
BA/CA ± SD | 0.81 ± 0.13 | 0.79 ± 0.14 | 0.83 ± 0.12 | 0.80 ± 0.14 | 0.78 ± 0.13 | 0.83 ± 0.11 | 0.82 ± 0.14 | 0.81 ± 0.14 | 0.83 ± 0.13 |
hSDS ± SD | −2.67 ± 0.65 | −2.64 ± 0.63 | −2.74 ± 0.68 | −2.68 ± 0.61 | −2.66 ± 0.58 | −2.71 ± 0.69 | −2.67 ± 0.68 | −2.62 ± 0.69 | −2.81 ± 0.69 |
IGF-1 ± SD [ng/mL] | 157.75 ± 91.62 | 155.81 ± 91.79 | 161.48 ± 91.63 | 149.78 ± 93.02 | 141.13 ± 82.62 | 164.84 ± 108.04 | 165.83 ± 89.77 | 169.68 ± 98.13 | 157.58 ± 68.89 |
IGF-1 SDS ± SD | −0.61 ± 1.03 | −0.78 ± 0.97 | −0.29 ± 1.07 | −0.67 ± 1.08 | −0.87 ± 1.03 | −0.34 ± 1.09 | −0.55 ± 0.99 | −0.70 ± 1.06 | −0.24 ± 1.06 |
TSH ± SD [µIU/mL] | 2.07 ±0.95 | 1.96 ± 0.89 | 2.29 ± 1.03 | 2.19 ± 1.03 | 2.07 ± 0.94 | 2.42 ± 1.17 | 1.96 ± 0.85 | 1.87 ± 0.84 | 2.14 ± 0.80 |
fT4 ± SD [ng/dL] | 1.09 ± 0.19 | 1.08 ± 0.17 | 1.10 ± 0.24 | 1.08 ± 0.19 | 1.09 ± 0.20 | 1.06 ± 0.18 | 1.10 ± 0.20 | 1.07 ± 0.13 | 1.15 ± 0.30 |
25OHD ± SD [ng/mL] | 25.36 ± 11.15 | 25.48 ± 11.25 | 25.81 ± 11.26 | 25.11 ± 10.05 | 24.54 ± 9.48 | 26.06 ± 11.10 | 25.62 ± 12.72 | 26.38 ± 12.67 | 25.00 ± 11.54 |
HGB ± SD [g/dL] | 13.47 ± 7.97 | 13.80 ± 10.03 | 12.88 ± 0.93 | 12.92 ± 1.01 | 13.00 ± 1.00 | 12.74 ± 0.99 | 14.02 ± 11.26 | 14.57 ± 13.98 | 13.02 ± 0.82 |
Birth weight ± SD [g] | 3065.8 ± 657.55 | 3119.2 ± 655.75 | 2967.3 ± 652.82 | 3118.0 ± 627.20 | 3148.2 ± 624.0 | 3064.8 ± 635.35 | 3015.1 ± 687.09 | 3093.8 ± 690.00 | 2861.3 ± 661.90 |
All Children with Short Stature (n = 277) | Children with gH Peak <10 ng/mL (n = 138) | Children with GH Peak ≥10 ng/mL (n = 139) | |||||||
---|---|---|---|---|---|---|---|---|---|
All | Boys | Girls | All | Boys | Girls | All | Boys | Girls | |
Number | 277 | 181 | 96 | 138 | 88 | 50 | 139 | 93 | 46 |
Celiac disease | 11 (4%) | 6 (3.3%) | 5 (5.2%) | 6 (4.3%) | 4 (4.5%) | 2 (4%) | 5 (3.6%) | 2 (2.2%) | 3 (6.5%) |
Hypothyroidism * | 5 (1.8%) | 2 (1.1%) | 3 (3.1%) | 3 (2.2%) | 0 (0.0%) | 3 (6.0%) | 2 (1.4%) | 2 (2.2%) | 0 (0.0%) |
Anemia | 8 (2.9%) | 6 (3.3%) | 2 (2.1%) | 6 (4.3%) | 4 (4.5%) | 2 (4.0%) | 2 (1.4%) | 2 (2.2%) | 0 (0.0%) |
Vitamin D deficiency | 100 (36.1%) | 64 (35.4%) | 36 (37.5%) | 49 (35.5%) | 34 (38.6%) | 15 (30.0%) | 51 (36.7%) | 30 (32.3%) | 21 (45.7%) |
Vitamin D insufficiency | 101 (36.5%) | 67 (37.2%) | 34 (35.4%) | 58 (42.3%) | 37 (42.5%) | 21 (42.0%) | 43 (30.9%) | 30 (32.3%) | 13 (28.3%) |
Regular intake of vitamin D | 14 (5.1%) | 9 (5.0%) | 5 (5.2%) | 5 (3.6%) | 2 (2.3%) | 3 (6.0%) | 9 (6.5%) | 7 (7.5%) | 2 (4.3%) |
SGA | 56 (20.2%) | 34 (18.4%) | 22 (22.9%) | 25 (18.2%) | 15 (17.2%) | 10 (20%) | 31 (22.3%) | 19 (20.4%) | 12 (26.1%) |
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Majewska, K.A.; Tchorzewska-Skrobich, M.; Wais, P.; Majewski, D.; Naskręcka, M.; Kędzia, A. Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical Differences. Biomedicines 2024, 12, 1673. https://doi.org/10.3390/biomedicines12081673
Majewska KA, Tchorzewska-Skrobich M, Wais P, Majewski D, Naskręcka M, Kędzia A. Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical Differences. Biomedicines. 2024; 12(8):1673. https://doi.org/10.3390/biomedicines12081673
Chicago/Turabian StyleMajewska, Katarzyna Anna, Magdalena Tchorzewska-Skrobich, Paulina Wais, Dominik Majewski, Monika Naskręcka, and Andrzej Kędzia. 2024. "Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical Differences" Biomedicines 12, no. 8: 1673. https://doi.org/10.3390/biomedicines12081673