Precise Definition of Porcine Hippocampal Cornu Ammonis 2: High Histoarchitectural Similarity to Humans but Unequal Sensitivity to Hypoxia
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Lana, D.; Ugolini, F.; Giovannini, M.G. An Overview on the Differential Interplay Among Neurons-Astrocytes-Microglia in CA1 and CA3 Hippocampus in Hypoxia/Ischemia. Front. Cell. Neurosci. 2020, 14, 585833. [Google Scholar] [CrossRef] [PubMed]
- Mohnke, K.; Conzelmann, P.; Renz, M.; Riedel, J.; Rissel, R.; Urmann, A.; Hain, J.; Duenges, B.; Ziebart, A.; Ruemmler, R. Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: Insights from a porcine model. Intensive Care Med. Exp. 2023, 11, 81. [Google Scholar] [CrossRef] [PubMed]
- Ruemmler, R.; Ziebart, A.; Moellmann, C.; Garcia-Bardon, A.; Kamuf, J.; Kuropka, F.; Duenges, B.; Hartmann, E.K. Ultra-low tidal volume ventilation—A novel and effective ventilation strategy during experimental cardiopulmonary resuscitation. Resuscitation 2018, 132, 56–62. [Google Scholar] [CrossRef] [PubMed]
- Félix, B.; Léger, M.E.; Albe-Fessard, D.; Marcilloux, J.C.; Rampin, O.; Laplace, J.P. Stereotaxic atlas of the pig brain. Brain Res Bull. 1999, 49, 1–137. [Google Scholar] [CrossRef] [PubMed]
- Dudek, S.M.; Alexander, G.M.; Farris, S. Rediscovering area CA2: Unique properties and functions. Nat. Rev. Neurosci. 2016, 17, 89–102. [Google Scholar] [CrossRef] [PubMed]
- Bartesaghi, R.; Ravasi, L. Pyramidal neuron types in field CA2 of the guinea pig. Brain Res. Bull. 1999, 50, 263–273. [Google Scholar] [CrossRef] [PubMed]
- Leranth, C.; Ribak, C.E. Calcium-binding proteins are concentrated in the CA2 field of the monkey hippocampus: A possible key to this region’s resistance to epileptic damage. Exp. Brain Res. 1991, 85, 129–136. [Google Scholar] [CrossRef] [PubMed]
- D’Erchia, A.M.; Gissi, C.; Pesole, G.; Saccone, C.; Arnason, U. The guinea-pig is not a rodent. Nature 1996, 381, 597–600. [Google Scholar] [CrossRef] [PubMed]
- Braak, H. On the structure of the human archicortex. I. The cornu ammonis. A Golgi and pigmentarchitectonic study. Cell Tissue Res. 1974, 152, 349–383. [Google Scholar] [CrossRef] [PubMed]
- Högler, S.; Sterz, F.; Sipos, W.; Schratter, A.; Weihs, W.; Holzer, M.; Janata, A.; Losert, U.; Behringer, W.; Tichy, A.; et al. Distribution of neuropathological lesions in pig brains after different durations of cardiac arrest. Resuscitation 2010, 81, 1577–1583. [Google Scholar] [CrossRef] [PubMed]
- Insausti, R.; Muñoz-López, M.; Insausti, A.M. The CA2 hippocampal subfield in humans: A review. Hippocampus 2023, 33, 712–729. [Google Scholar] [CrossRef] [PubMed]
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Renz, M.; Siegert, P.; Mohnke, K.; Ruemmler, R.; Frauenknecht, K.; Sommer, C.; Harder, A. Precise Definition of Porcine Hippocampal Cornu Ammonis 2: High Histoarchitectural Similarity to Humans but Unequal Sensitivity to Hypoxia. Biomedicines 2024, 12, 1896. https://doi.org/10.3390/biomedicines12081896
Renz M, Siegert P, Mohnke K, Ruemmler R, Frauenknecht K, Sommer C, Harder A. Precise Definition of Porcine Hippocampal Cornu Ammonis 2: High Histoarchitectural Similarity to Humans but Unequal Sensitivity to Hypoxia. Biomedicines. 2024; 12(8):1896. https://doi.org/10.3390/biomedicines12081896
Chicago/Turabian StyleRenz, Miriam, Pascal Siegert, Katja Mohnke, Robert Ruemmler, Katrin Frauenknecht, Clemens Sommer, and Anja Harder. 2024. "Precise Definition of Porcine Hippocampal Cornu Ammonis 2: High Histoarchitectural Similarity to Humans but Unequal Sensitivity to Hypoxia" Biomedicines 12, no. 8: 1896. https://doi.org/10.3390/biomedicines12081896