Could the Early Detection of Atrial Fibrillation Reduce the Risk of Developing Dementia?
Abstract
:1. Impact of Atrial Fibrillation and Dementia
2. Cognitive Function and Dementia
3. Shared Confounders
4. Suspected Mechanisms
5. Causality or Shared Risk Factors
6. Rhythm Control Strategies
7. Anticoagulation
8. Integrated Approaches
9. Potential Benefits of Early AF Detection
10. Conclusions and Future Directions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
AF | Atrial fibrillation |
AADs | Antiarrhythmic drugs |
AD | Alzheimer’s disease |
AFCOG | Acute cognitive changes during atrial fibrillation episodes |
AFFIRM | Atrial Fibrillation Follow-up Investigation of Rhythm Management |
ARIC | Atherosclerosis Risk in Communities |
ARISTA | Trial of Apixaban vs warfarin in reducing Rate of cognitive decline, silent cerebral ischemia and cerebral microbleeds in patients with atrial fibrillation |
BNP | B-type natriuretic peptide |
BRAIN-AF trial | Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in Atrial Fibrillation |
CAF trial | Impact of anticoagulation therapy on the cognitive decline and dementia in patients with nonvalvular atrial fibrillation |
CHA2DS2VASc score | Congestive heart failure (1 point), Hypertension (1 point), Age ≥ 75 (2 points), Diabetes (1 point), prior Stroke or TIA (2 points), Vascular disease (1 point), Age 65–74 (1 point), and Sex (female; 1 point) |
EAST-AFNET 4 | Early Treatment of Atrial Fibrillation for Stroke Prevention Trial 4 |
FINGER | Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability |
LAAO | Left atrial appendage occlusion |
MACPAF | Prospective Impact of atrial fibrillation burden on cognitive function after left atrial ablation study |
MMSE | Mini-Mental State Examination |
MoCA | Montreal Cognitive Assessment |
NOACs | Non-vitamin K antagonist oral anticoagulants |
OAC | Oral anticoagulation |
OCEAN trial | Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial |
PLUG | Overall and MRI-based Impact of Percutaneous Left Atrial Appendage Closure on the Cognitive Decline and Dementia in Patients With AF |
PAFs | Population attributable fractions |
TIA | Transient ischemic attack |
USA | United States of America |
VKA | Vitamin K antagonist |
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Main Shared Risk Factors |
---|
Age |
Arterial hypertension |
Diabetes mellitus |
Coronary artery disease |
Excessive alcohol consumption |
Heart failure |
Hyperlipidemia |
Obesity and Western diet |
Physical inactivity |
Sleep apnea and chronic sleep deprivation |
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Demoniere, F.; Abdelli, R.; Rivard, L. Could the Early Detection of Atrial Fibrillation Reduce the Risk of Developing Dementia? Biomedicines 2024, 12, 1931. https://doi.org/10.3390/biomedicines12081931
Demoniere F, Abdelli R, Rivard L. Could the Early Detection of Atrial Fibrillation Reduce the Risk of Developing Dementia? Biomedicines. 2024; 12(8):1931. https://doi.org/10.3390/biomedicines12081931
Chicago/Turabian StyleDemoniere, Fabrice, Rim Abdelli, and Léna Rivard. 2024. "Could the Early Detection of Atrial Fibrillation Reduce the Risk of Developing Dementia?" Biomedicines 12, no. 8: 1931. https://doi.org/10.3390/biomedicines12081931