Investigation of Type A Aortic Dissection Using Computational Modelling
Abstract
:1. Introduction
- Type A is not well studied using CFD modelling due to difficulties in performing the required CT scan images, as some patients die in the community prior to hospitalisation.
- To the best of our knowledge, few studies have investigated the utility of CFD in the same patient (i.e., before and after the aortic dissection), as this kind of study would require months to years of waiting for the development of the patient’s condition.
- Many CFD studies focus on the pressure and velocity profiles in the true and false lumen, mainly in Type B patients and a few Type A patients, with a focus on the WSS, TAWSS, and OSI.
- The literature did not investigate critical parameters such as relative residence time (RRT) and endothelial cell activation potential (ECAP).
2. Materials and Methods
2.1. Patient-Specific CT Scans
2.2. 3D Geometry
2.3. Mesh
2.4. CFD Setup and Boundary Conditions
2.5. Validation
3. Results
3.1. Blood Pressure and Velocity Profiles
3.2. WSS Parameters
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Mesh # | Cells | WSSmax [Pa] Steady Case | Pressuremax [mmHg] Ascending/Descending | Velocitymax [m/s] Ascending/Descending | Wall Y+ for Steady Case |
---|---|---|---|---|---|
Before-1 | 412,352 | 9.1 | 139.58/141.43 | 0.63/0.87 | 1.91 |
Before-2 | 414,748 | 11 | 140.48/141.86 | 0.63/0.87 | 1.77 |
Before-3 | 949,210 | 11 | 141.66/141.83 | 0.63/0.87 | 1.41 |
After-3 | 1,408,138 | 12 | 186.144/135.06 136.42/167.58 | 0.63/0.59 0.97/0.77 | 2.85 |
After-2 | 2,270,812 | 13.92 | 186/136.2 137.08/167.36 | 0.63/0.81 0.912/0.766 | 2.69 |
After-1 | 2,328,909 | 17.98 | 188.08/136.98 139.80/168.59 | 0.64/0.44 1.01/0.74 | 1.9 |
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Al-Rawi, M.; Belkacemi, D.; Lim, E.T.A.; Khashram, M. Investigation of Type A Aortic Dissection Using Computational Modelling. Biomedicines 2024, 12, 1973. https://doi.org/10.3390/biomedicines12091973
Al-Rawi M, Belkacemi D, Lim ETA, Khashram M. Investigation of Type A Aortic Dissection Using Computational Modelling. Biomedicines. 2024; 12(9):1973. https://doi.org/10.3390/biomedicines12091973
Chicago/Turabian StyleAl-Rawi, Mohammad, Djelloul Belkacemi, Eric T. A. Lim, and Manar Khashram. 2024. "Investigation of Type A Aortic Dissection Using Computational Modelling" Biomedicines 12, no. 9: 1973. https://doi.org/10.3390/biomedicines12091973