Investigation of the Diagnostic Value of Cerebrospinal Fluid and Serum sTREM-1 Levels in Neonatal Meningitis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Design
2.2. Population
2.3. Analysis of Samples
2.4. Statistics
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Term Neonates, n = 27 | p | Preterm Neonates, n = 50 | p | |||
---|---|---|---|---|---|---|
With meningitis, n = 14 | Without meningitis, n = 13 | With meningitis, n = 18 | Without meningitis, n = 32 | |||
Gestational age (week), median (min-max) | 38.2 (37–40) | 38.3 (37–39) | 0.903 a | 31.5 (26.3–36.5) | 31.3 (26.5–36.6) | 0.816 a |
Birth weight (gr), median (min-max) | 3260 (2470–4180) | 2970 (2400–3800) | 0.234 a | 1587 (780–3100) | 1625 (860–3300) | 0.657 a |
Gender (n, Female/male) | 8/6 | 7/6 | 0.863 b | 6/12 | 18/14 | 0.119 b |
Cesarean section (n) | 7 | 7 | 0.842 b | 18 | 28 | 0.283 b |
Maternal age (year), median (min-max) | 28 (23–34) | 31 (24–42) | 0.381 a | 29 (22–40) | 30 (19–40) | 0.562 a |
Apgar 1. minute, median (min-max) | 8 (3–9) | 8 (1–9) | 0.612 a | 7 (0–9) | 7 (2–9) | 0.947 a |
Apgar 5. minute, median (min-max) | 9 (7–10) | 9 (1–10) | 0.489 a | 9 (2–9) | 8 (6–10) | 0.855 a |
Postnatal age (day), median (min-max) | 4 (2–25) | 3 (2–25) | 0.673 a | 5 (2–44) | 4 (1–30) | 0.820 a |
Early/late neonatal sepsis (n) | 3/11 | 4/9 | 0.580 b | 3/15 | 5/27 | 0.923 b |
Term Neonates, n = 27 | p | Preterm Neonates, n = 50 | p | |||
---|---|---|---|---|---|---|
With meningitis, n = 14 | Without meningitis, n = 13 | With meningitis, n = 18 | Without meningitis, n = 32 | |||
Serum sTREM1 (pg/mL), median (IQR) | 354.1 (187.5–545.5) | 254.1 (211.1–538.8) | 0.951 a | 252.2 (145.2–308.6) | 296.7 (234.7–447.7) | 0.038 a |
CSF sTREM1 (pg/mL), median (IQR) | 252.8 (209.6–384.2) | 262.4 (188.7–406.4) | 0.865 a | 290.4 (218.6–360.6) | 339.3 (240.8–390.8) | 0.147 a |
CSF/serum sTREM-1, mean ± SD | 1.15 ± 0.97 | 0.97 ± 0.55 | 0.583 b | 1.42 ± 0.91 | 1.14 ± 0.85 | 0.294 b |
Term Neonates, n = 14 | Preterm Neonates, n = 18 | |||||
---|---|---|---|---|---|---|
sTREM1 (pg/mL) | Serum | CSF | CSF/serum sTREM-1 | Serum | CSF | CSF/serum sTREM-1 |
Day 0, median, (IQR) | 354.1 (187.5–545.5) | 252.8 (209.6–384.2) | 0.84 (0.35–1.93) | 252.2 (145.2–308.6) | 290.4 (218.6–360.6) | 1.17 (0.80–1.79) |
Day 2, median (IQR) | 281.5 (228.0–403.6) | 238.8 (203.1–410.6) | 0.72 (0.65–1.44) | 252.7 (195.7–307.1) | 226.0 (201.8–357.3) | 0.84 (0.48–1.09) |
P | 0.398 | 0.929 | 0.866 | 0.309 | 0.038 | 0.086 |
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Çakır, S.Ç.; Dorum, B.A.; Özkan, H.; Köksal, N.; Kocael, F.; Budak, F.; Hacımustafaoğlu, M.; Çelebi, S.; Kızmaz, M.A.; Sivrikaya Yıldırım, C.; et al. Investigation of the Diagnostic Value of Cerebrospinal Fluid and Serum sTREM-1 Levels in Neonatal Meningitis. Children 2024, 11, 1026. https://doi.org/10.3390/children11081026
Çakır SÇ, Dorum BA, Özkan H, Köksal N, Kocael F, Budak F, Hacımustafaoğlu M, Çelebi S, Kızmaz MA, Sivrikaya Yıldırım C, et al. Investigation of the Diagnostic Value of Cerebrospinal Fluid and Serum sTREM-1 Levels in Neonatal Meningitis. Children. 2024; 11(8):1026. https://doi.org/10.3390/children11081026
Chicago/Turabian StyleÇakır, Salih Çağrı, Bayram Ali Dorum, Hilal Özkan, Nilgün Köksal, Fatma Kocael, Ferah Budak, Mustafa Hacımustafaoğlu, Solmaz Çelebi, Muhammed Ali Kızmaz, Cansu Sivrikaya Yıldırım, and et al. 2024. "Investigation of the Diagnostic Value of Cerebrospinal Fluid and Serum sTREM-1 Levels in Neonatal Meningitis" Children 11, no. 8: 1026. https://doi.org/10.3390/children11081026