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Children
Volume 12
Issue 5
10.3390/children12050559
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Review

Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft—A Review

by
Anna Miguel-Escribano
1,
Cosimo Galletti
2,
Juan de Quixano-Bardaji
1,
Francisco Real-Voltas
1,
Luca Fiorillo
3,
Maria Cuevas-Nunez
4,
Fulvia Galletti
4 and
Javier Flores-Fraile
5,*
1
Department of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallés, Spain
2
School of Medicine and Surgery Kore, University of Enna, 94100 Enna, Italy
3
Department of Dental Cell Research, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pune 411018, Maharashtra, India
4
Department of Biomedical and Dental Science and Morphological and Functional Imaging, University of Messina, 98166 Messina, Italy
5
Department of Surgery, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain
*
Author to whom correspondence should be addressed.
Children 2025, 12(5), 559; https://doi.org/10.3390/children12050559 (registering DOI)
Submission received: 12 March 2025 / Revised: 15 April 2025 / Accepted: 22 April 2025 / Published: 26 April 2025
(This article belongs to the Section Pediatric Dentistry & Oral Medicine)
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Abstract

Anterior lip/palate cleft is a congenital deformity affecting the upper lip and palate, posing significant challenges in both aesthetic and functional aspects for children. Effective management of this condition is crucial for improving quality of life and ensuring normal development. This review aims to highlight the regenerative treatment options available for children with anterior lip/palate cleft, focusing on the use of bone grafts and other advanced dental procedures. A review of the current literature and clinical practices was conducted to identify and evaluate the most effective treatment options. Emphasis was placed on regenerative techniques, particularly the use of bone grafts. Advancements in regenerative dentistry offer promising outcomes for children with anterior lip/palate cleft. Bone grafts, combined with innovative techniques such as growth factors, stem cell therapy, and distraction osteogenesis, provide effective solutions for restoring function and aesthetics. A multidisciplinary approach is essential to ensure comprehensive care and optimal results for these patients.
Keywords: cleft lip; cleft palate; embryology; etiology; epidemiology; bone graft; alveolar bone grafting; secondary alveolar bone grafting cleft lip; cleft palate; embryology; etiology; epidemiology; bone graft; alveolar bone grafting; secondary alveolar bone grafting

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MDPI and ACS Style

Miguel-Escribano, A.; Galletti, C.; de Quixano-Bardaji, J.; Real-Voltas, F.; Fiorillo, L.; Cuevas-Nunez, M.; Galletti, F.; Flores-Fraile, J. Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft—A Review. Children 2025, 12, 559. https://doi.org/10.3390/children12050559

AMA Style

Miguel-Escribano A, Galletti C, de Quixano-Bardaji J, Real-Voltas F, Fiorillo L, Cuevas-Nunez M, Galletti F, Flores-Fraile J. Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft—A Review. Children. 2025; 12(5):559. https://doi.org/10.3390/children12050559

Chicago/Turabian Style

Miguel-Escribano, Anna, Cosimo Galletti, Juan de Quixano-Bardaji, Francisco Real-Voltas, Luca Fiorillo, Maria Cuevas-Nunez, Fulvia Galletti, and Javier Flores-Fraile. 2025. "Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft—A Review" Children 12, no. 5: 559. https://doi.org/10.3390/children12050559

APA Style

Miguel-Escribano, A., Galletti, C., de Quixano-Bardaji, J., Real-Voltas, F., Fiorillo, L., Cuevas-Nunez, M., Galletti, F., & Flores-Fraile, J. (2025). Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft—A Review. Children, 12(5), 559. https://doi.org/10.3390/children12050559

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