Pro-Inflammatory Oral Microbiota in Juvenile Spondyloarthritis: A Pilot Study
Abstract
:1. Introduction
2. Patients and Methods
2.1. Overview
2.2. Subjects
2.3. Collection of Samples
2.4. Sequencing and Analysis of 16S Ribosomal DNA from the Salivary and Sub-Gingival Specimens
2.5. Power Calculations for a Definitive Study
2.6. Statistical Analyses
3. Results
3.1. Subjects
3.2. 16S Sequencing
3.3. Proposal for Definitive Study
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Feature | Healthy Controls | Juvenile Spondyloarthritis |
---|---|---|
n | 6 | 5 |
Demographics | ||
Male Sex | 2 (33%) | 1 (20%) |
Race | ||
White | 5 (83%) | 5 (100%) |
Black | 1 (17%) | 0 |
Age (years) | 14.4 ± 2.1 | 14.3 ± 2.0 |
Treatment | ||
Etanercept | 0 | 1 (20%) |
TNFi mAb | 0 | 3 (60%) |
Abatacept | 0 | 1 (20%) |
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Stoll, M.L.; Wang, J.; Kau, C.H.; Pierce, M.K.; Morrow, C.D.; Geurs, N.C. Pro-Inflammatory Oral Microbiota in Juvenile Spondyloarthritis: A Pilot Study. Children 2022, 9, 1764. https://doi.org/10.3390/children9111764
Stoll ML, Wang J, Kau CH, Pierce MK, Morrow CD, Geurs NC. Pro-Inflammatory Oral Microbiota in Juvenile Spondyloarthritis: A Pilot Study. Children. 2022; 9(11):1764. https://doi.org/10.3390/children9111764
Chicago/Turabian StyleStoll, Matthew L, Jue Wang, Chung How Kau, Margaret Kathy Pierce, Casey D Morrow, and Nicolaas C Geurs. 2022. "Pro-Inflammatory Oral Microbiota in Juvenile Spondyloarthritis: A Pilot Study" Children 9, no. 11: 1764. https://doi.org/10.3390/children9111764