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Peer-Review Record

How Does Long-Term Storage Influence the Physical Stability and Dissolution of Bicalutamide from Solid Dispersions and Minitablets?

Processes 2022, 10(5), 1002; https://doi.org/10.3390/pr10051002
by Agata Antosik-Rogóż 1,*, Joanna Szafraniec-Szczęsny 1,2, Justyna Knapik-Kowalczuk 3, Mateusz Kurek 1, Karolina Gawlak 2, Marian Paluch 3 and Renata Jachowicz 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Processes 2022, 10(5), 1002; https://doi.org/10.3390/pr10051002
Submission received: 29 April 2022 / Revised: 12 May 2022 / Accepted: 16 May 2022 / Published: 18 May 2022
(This article belongs to the Special Issue Studies of the Dosage Form and Stability of the Drug by Various Techniques)

Round 1

Reviewer 1 Report

 How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets?

 

This manuscript conducts the processes to develop bicalutamide minitablet using solid dispersion and packaging techniques to present the good physical stability and dissolution study with 28 refs.

  1. What condition is the 1% SLS dissolution medium mimic for in the GI tract?
  2. Fig 1, add the name and unit of the Y-axis. Is there an SD error bar in this fig?
  3. Fig 2,3,6 adds the name and unit of the Y-axis.
  4. How about the most critical issue, “drug content uniformity and stability of the drug in all conditions of stability test? Did the developed formulation pass the criteria of assay content? Because the authors did not show the assay content result of the formulation, only the dissolution might not be enough to prove that this is a successful formulation. Although, the title of the ms mentioned only the physical stability and dissolution of the drug. In the pharmaceutical industry or R&D workflow, the physical stability and dissolution of the drug is just 30% of the overall R&D process. The pharmacist should concentrate on the assay content of the drug to deliver the high-quality medicine to the patient, not only get the good physical stability and dissolution study. Assay content in the final product and the stability of drug along their shelf life are required. So, the successful formulation must mention its drug content uniformity, assay content, and chemical stability, then combined with physical stability and dissolution study. 

Author Response

Dear Reviewer, please see the attachement.

Author Response File: Author Response.docx

Reviewer 2 Report

I want to thank the authors for the interesting manuscript we they are describing and providing an improvement for an important problem. Hereafter are some minor comments from my side:

Line 94: You state solubility as very low aqueous solubility. As you later frequently reference to the Ph. Eur. methods you might also want to classify this parameter accordingly. 

Line 126: The mixtures you prepared in certain ratios are crucial for your conclusion. You might want to state the model of the balance, its range and limits that were used for these preparations in a single sentence.

Line 215: Are the previous studies published and could you cite them here? Or else you should state that you include unpublished data into the description.

Figure 1: The "µm" in the legend could be misleading. I would encourage you to delete these and move them to the y-axis as there the unit is missing. Also, if you have the data available from this analysis, a depiction of the whole data of the particle sizes in a boxplot might be even more informative.

Line 230: Which instrument or method did you use to assess that the agglomerates were easy to pulverize? Was it the same as you state in line 237/8?

Table 1: In the half month row for the accelerated conditions and a rati0 of 2:1 you state "Slightly beige, agglomerated (less that 1:1)" in the Polysterene container column. I did not understand what is inside the brackets. Could you please elaborate for me and also for the future reader?

Fig. 2+3a-j: All the axis are missing their respective units. Please indicate them for the sake of completeness. Also, the method for overlay is not clearly described. I would assume that the lines all start close to zero, normally? Therefore, please elaborate in the caption. Additionally, in the later subfigures c, g, h, i and j the graphs are strongly overlapping. You could zoom out the y-axis further to cope with this unless the effects that you want to show are not perceptible like that.

Figure 4: Am was at the first glance puzzled by the "start" title of this graph. Could you make this more clear? Also, the error indicators of the last time point depicted are not showing entirely. Could you check if the x-axis can be any wider to resolve this?

Figure 5d: It might just be a problem with the pdf that I got for review but the "BL" for blister is not shown cleanly as it reads "Bl." in my document. Can you confirm that these legends are the same for all the graphs?

Figure 6: Please add units to the y-axis even or especially if they are arbitrarily chosen.

Figure 7: Here I encountered the same as with the error indicators in Fig. 4.

 

Author Response

Dear Reviewer, please see the attachement.

Author Response File: Author Response.docx

Reviewer 3 Report

Dear Authors,

I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

 

A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

 

  1. English should be improved throughout the article.
  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
  3. The major results and conclusions must be included in the abstract.
  4. The title of the manuscript must be convenient or included the idea of the novelty.
  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

 

  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

 

  1. I have not found comparative between this study with other literatures.

 

  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

 

  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

 

  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

 

  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

 

  1. What is the main conclusion from this study? The conclusion must be reduced.

International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

 

  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

    Dear Editor,

    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

     

    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

     

    1. English should be improved throughout the article.
    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
    3. The major results and conclusions must be included in the abstract.
    4. The title of the manuscript must be convenient or included the idea of the novelty.
    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

     

    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

     

    1. I have not found comparative between this study with other literatures.

     

    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

     

    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

     

    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

     

    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

     

    1. What is the main conclusion from this study? The conclusion must be reduced.

    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

     

    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

      Dear Editor,

      I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

       

      A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

      B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

      1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
      2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

       

      1. English should be improved throughout the article.
      2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
      3. The major results and conclusions must be included in the abstract.
      4. The title of the manuscript must be convenient or included the idea of the novelty.
      5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
      6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

       

      1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

      Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

       

      1. I have not found comparative between this study with other literatures.

       

      1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

      Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

       

      1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

       

      1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

       

      1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

       

      1. What is the main conclusion from this study? The conclusion must be reduced.

      International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

       

      1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

        Dear Editor,

        I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

         

        A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

        B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

        1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
        2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

         

        1. English should be improved throughout the article.
        2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
        3. The major results and conclusions must be included in the abstract.
        4. The title of the manuscript must be convenient or included the idea of the novelty.
        5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
        6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

         

        1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

        Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

         

        1. I have not found comparative between this study with other literatures.

         

        1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

        Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

         

        1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

         

        1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

         

        1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

         

        1. What is the main conclusion from this study? The conclusion must be reduced.

        International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

         

        1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

          Dear Editor,

          I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

           

          A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

          B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

          1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
          2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

           

          1. English should be improved throughout the article.
          2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
          3. The major results and conclusions must be included in the abstract.
          4. The title of the manuscript must be convenient or included the idea of the novelty.
          5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
          6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

           

          1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

          Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

           

          1. I have not found comparative between this study with other literatures.

           

          1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

          Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

           

          1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

           

          1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

           

          1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

           

          1. What is the main conclusion from this study? The conclusion must be reduced.

          International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

           

          1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

            Dear Editor,

            I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

             

            A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

            B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

            1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
            2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

             

            1. English should be improved throughout the article.
            2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
            3. The major results and conclusions must be included in the abstract.
            4. The title of the manuscript must be convenient or included the idea of the novelty.
            5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
            6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

             

            1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

            Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

             

            1. I have not found comparative between this study with other literatures.

             

            1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

            Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

             

            1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

             

            1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

             

            1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

             

            1. What is the main conclusion from this study? The conclusion must be reduced.

            International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

             

            1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

              Dear Editor,

              I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

               

              A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

              B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

              1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
              2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

               

              1. English should be improved throughout the article.
              2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
              3. The major results and conclusions must be included in the abstract.
              4. The title of the manuscript must be convenient or included the idea of the novelty.
              5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
              6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

               

              1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

              Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

               

              1. I have not found comparative between this study with other literatures.

               

              1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

              Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

               

              1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

               

              1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

               

              1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

               

              1. What is the main conclusion from this study? The conclusion must be reduced.

              International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

               

              1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                Dear Editor,

                I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                 

                A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                 

                1. English should be improved throughout the article.
                2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                3. The major results and conclusions must be included in the abstract.
                4. The title of the manuscript must be convenient or included the idea of the novelty.
                5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                 

                1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                 

                1. I have not found comparative between this study with other literatures.

                 

                1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                 

                1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                 

                1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                 

                1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                 

                1. What is the main conclusion from this study? The conclusion must be reduced.

                International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                 

                1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                  Dear Editor,

                  I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                   

                  A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                  B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                   

                  1. English should be improved throughout the article.
                  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                  3. The major results and conclusions must be included in the abstract.
                  4. The title of the manuscript must be convenient or included the idea of the novelty.
                  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                   

                  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                  Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                   

                  1. I have not found comparative between this study with other literatures.

                   

                  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                  Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                   

                  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                   

                  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                   

                  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                   

                  1. What is the main conclusion from this study? The conclusion must be reduced.

                  International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                   

                  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                    Dear Editor,

                    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                     

                    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                     

                    1. English should be improved throughout the article.
                    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                    3. The major results and conclusions must be included in the abstract.
                    4. The title of the manuscript must be convenient or included the idea of the novelty.
                    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                     

                    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                     

                    1. I have not found comparative between this study with other literatures.

                     

                    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                     

                    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                     

                    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                     

                    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                     

                    1. What is the main conclusion from this study? The conclusion must be reduced.

                    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                     

                    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                      Dear Editor,

                      I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                       

                      A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                      B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                      1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                      2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                       

                      1. English should be improved throughout the article.
                      2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                      3. The major results and conclusions must be included in the abstract.
                      4. The title of the manuscript must be convenient or included the idea of the novelty.
                      5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                      6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                       

                      1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                      Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                       

                      1. I have not found comparative between this study with other literatures.

                       

                      1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                      Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                       

                      1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                       

                      1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                       

                      1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                       

                      1. What is the main conclusion from this study? The conclusion must be reduced.

                      International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                       

                      1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                        Dear Editor,

                        I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                         

                        A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                        B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                        1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                        2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                         

                        1. English should be improved throughout the article.
                        2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                        3. The major results and conclusions must be included in the abstract.
                        4. The title of the manuscript must be convenient or included the idea of the novelty.
                        5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                        6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                         

                        1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                        Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                         

                        1. I have not found comparative between this study with other literatures.

                         

                        1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                        Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                         

                        1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                         

                        1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                         

                        1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                         

                        1. What is the main conclusion from this study? The conclusion must be reduced.

                        International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                         

                        1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                          Dear Editor,

                          I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                           

                          A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                          B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                          1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                          2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                           

                          1. English should be improved throughout the article.
                          2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                          3. The major results and conclusions must be included in the abstract.
                          4. The title of the manuscript must be convenient or included the idea of the novelty.
                          5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                          6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                           

                          1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                          Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                           

                          1. I have not found comparative between this study with other literatures.

                           

                          1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                          Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                           

                          1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                           

                          1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                           

                          1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                           

                          1. What is the main conclusion from this study? The conclusion must be reduced.

                          International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                           

                          1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                            Dear Editor,

                            I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                             

                            A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                            B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                            1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                            2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                             

                            1. English should be improved throughout the article.
                            2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                            3. The major results and conclusions must be included in the abstract.
                            4. The title of the manuscript must be convenient or included the idea of the novelty.
                            5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                            6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                             

                            1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                            Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                             

                            1. I have not found comparative between this study with other literatures.

                             

                            1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                            Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                             

                            1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                             

                            1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                             

                            1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                             

                            1. What is the main conclusion from this study? The conclusion must be reduced.

                            International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                             

                            1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                              Dear Editor,

                              I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                               

                              A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                              B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                              1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                              2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                               

                              1. English should be improved throughout the article.
                              2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                              3. The major results and conclusions must be included in the abstract.
                              4. The title of the manuscript must be convenient or included the idea of the novelty.
                              5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                              6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                               

                              1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                              Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                               

                              1. I have not found comparative between this study with other literatures.

                               

                              1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                              Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                               

                              1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                               

                              1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                               

                              1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                               

                              1. What is the main conclusion from this study? The conclusion must be reduced.

                              International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                               

                              1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                Dear Editor,

                                I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                 

                                A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                 

                                1. English should be improved throughout the article.
                                2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                3. The major results and conclusions must be included in the abstract.
                                4. The title of the manuscript must be convenient or included the idea of the novelty.
                                5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                 

                                1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                 

                                1. I have not found comparative between this study with other literatures.

                                 

                                1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                 

                                1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                 

                                1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                 

                                1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                 

                                1. What is the main conclusion from this study? The conclusion must be reduced.

                                International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                 

                                1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                  Dear Editor,

                                  I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                   

                                  A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                  B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                   

                                  1. English should be improved throughout the article.
                                  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                  3. The major results and conclusions must be included in the abstract.
                                  4. The title of the manuscript must be convenient or included the idea of the novelty.
                                  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                   

                                  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                  Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                   

                                  1. I have not found comparative between this study with other literatures.

                                   

                                  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                  Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                   

                                  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                   

                                  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                   

                                  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                   

                                  1. What is the main conclusion from this study? The conclusion must be reduced.

                                  International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                   

                                  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                    Dear Editor,

                                    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                     

                                    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                     

                                    1. English should be improved throughout the article.
                                    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                    3. The major results and conclusions must be included in the abstract.
                                    4. The title of the manuscript must be convenient or included the idea of the novelty.
                                    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                     

                                    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                     

                                    1. I have not found comparative between this study with other literatures.

                                     

                                    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                     

                                    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                     

                                    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                     

                                    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                     

                                    1. What is the main conclusion from this study? The conclusion must be reduced.

                                    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                     

                                    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                      Dear Editor,

                                      I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                       

                                      A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                      B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                      1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                      2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                       

                                      1. English should be improved throughout the article.
                                      2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                      3. The major results and conclusions must be included in the abstract.
                                      4. The title of the manuscript must be convenient or included the idea of the novelty.
                                      5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                      6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                       

                                      1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                      Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                       

                                      1. I have not found comparative between this study with other literatures.

                                       

                                      1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                      Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                       

                                      1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                       

                                      1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                       

                                      1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                       

                                      1. What is the main conclusion from this study? The conclusion must be reduced.

                                      International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                       

                                      1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                        Dear Editor,

                                        I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                         

                                        A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                        B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                        1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                        2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                         

                                        1. English should be improved throughout the article.
                                        2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                        3. The major results and conclusions must be included in the abstract.
                                        4. The title of the manuscript must be convenient or included the idea of the novelty.
                                        5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                        6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                         

                                        1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                        Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                         

                                        1. I have not found comparative between this study with other literatures.

                                         

                                        1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                        Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                         

                                        1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                         

                                        1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                         

                                        1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                         

                                        1. What is the main conclusion from this study? The conclusion must be reduced.

                                        International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                         

                                        1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                          Dear Editor,

                                          I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                           

                                          A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                          B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                          1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                          2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                           

                                          1. English should be improved throughout the article.
                                          2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                          3. The major results and conclusions must be included in the abstract.
                                          4. The title of the manuscript must be convenient or included the idea of the novelty.
                                          5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                          6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                           

                                          1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                          Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                           

                                          1. I have not found comparative between this study with other literatures.

                                           

                                          1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                          Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                           

                                          1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                           

                                          1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                           

                                          1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                           

                                          1. What is the main conclusion from this study? The conclusion must be reduced.

                                          International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                           

                                          1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                            Dear Editor,

                                            I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                             

                                            A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                            B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                            1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                            2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                             

                                            1. English should be improved throughout the article.
                                            2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                            3. The major results and conclusions must be included in the abstract.
                                            4. The title of the manuscript must be convenient or included the idea of the novelty.
                                            5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                            6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                             

                                            1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                            Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                             

                                            1. I have not found comparative between this study with other literatures.

                                             

                                            1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                            Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                             

                                            1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                             

                                            1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                             

                                            1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                             

                                            1. What is the main conclusion from this study? The conclusion must be reduced.

                                            International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                             

                                            1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                              Dear Editor,

                                              I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                               

                                              A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                              B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                              1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                              2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                               

                                              1. English should be improved throughout the article.
                                              2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                              3. The major results and conclusions must be included in the abstract.
                                              4. The title of the manuscript must be convenient or included the idea of the novelty.
                                              5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                              6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                               

                                              1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                              Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                               

                                              1. I have not found comparative between this study with other literatures.

                                               

                                              1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                              Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                               

                                              1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                               

                                              1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                               

                                              1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                               

                                              1. What is the main conclusion from this study? The conclusion must be reduced.

                                              International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                               

                                              1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                Dear Editor,

                                                I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                 

                                                A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                 

                                                1. English should be improved throughout the article.
                                                2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                3. The major results and conclusions must be included in the abstract.
                                                4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                 

                                                1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                 

                                                1. I have not found comparative between this study with other literatures.

                                                 

                                                1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                 

                                                1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                 

                                                1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                 

                                                1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                 

                                                1. What is the main conclusion from this study? The conclusion must be reduced.

                                                International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                 

                                                1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                  Dear Editor,

                                                  I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                   

                                                  A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                  B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                   

                                                  1. English should be improved throughout the article.
                                                  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                  3. The major results and conclusions must be included in the abstract.
                                                  4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                   

                                                  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                  Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                   

                                                  1. I have not found comparative between this study with other literatures.

                                                   

                                                  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                  Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                   

                                                  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                   

                                                  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                   

                                                  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                   

                                                  1. What is the main conclusion from this study? The conclusion must be reduced.

                                                  International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                   

                                                  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                    Dear Editor,

                                                    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                     

                                                    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                     

                                                    1. English should be improved throughout the article.
                                                    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                    3. The major results and conclusions must be included in the abstract.
                                                    4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                     

                                                    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                     

                                                    1. I have not found comparative between this study with other literatures.

                                                     

                                                    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                     

                                                    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                     

                                                    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                     

                                                    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                     

                                                    1. What is the main conclusion from this study? The conclusion must be reduced.

                                                    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                     

                                                    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                      Dear Editor,

                                                      I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                       

                                                      A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                      B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                      1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                      2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                       

                                                      1. English should be improved throughout the article.
                                                      2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                      3. The major results and conclusions must be included in the abstract.
                                                      4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                      5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                      6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                       

                                                      1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                      Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                       

                                                      1. I have not found comparative between this study with other literatures.

                                                       

                                                      1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                      Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                       

                                                      1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                       

                                                      1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                       

                                                      1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                       

                                                      1. What is the main conclusion from this study? The conclusion must be reduced.

                                                      International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                       

                                                      1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                        Dear Editor,

                                                        I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                         

                                                        A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                        B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                        1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                        2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                         

                                                        1. English should be improved throughout the article.
                                                        2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                        3. The major results and conclusions must be included in the abstract.
                                                        4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                        5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                        6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                         

                                                        1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                        Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                         

                                                        1. I have not found comparative between this study with other literatures.

                                                         

                                                        1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                        Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                         

                                                        1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                         

                                                        1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                         

                                                        1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                         

                                                        1. What is the main conclusion from this study? The conclusion must be reduced.

                                                        International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                         

                                                        1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                          Dear Editor,

                                                          I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                           

                                                          A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                          B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                          1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                          2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                           

                                                          1. English should be improved throughout the article.
                                                          2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                          3. The major results and conclusions must be included in the abstract.
                                                          4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                          5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                          6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                           

                                                          1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                          Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                           

                                                          1. I have not found comparative between this study with other literatures.

                                                           

                                                          1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                          Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                           

                                                          1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                           

                                                          1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                           

                                                          1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                           

                                                          1. What is the main conclusion from this study? The conclusion must be reduced.

                                                          International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                           

                                                          1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                            Dear Editor,

                                                            I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                             

                                                            A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                            B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                            1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                            2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                             

                                                            1. English should be improved throughout the article.
                                                            2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                            3. The major results and conclusions must be included in the abstract.
                                                            4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                            5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                            6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                             

                                                            1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                            Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                             

                                                            1. I have not found comparative between this study with other literatures.

                                                             

                                                            1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                            Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                             

                                                            1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                             

                                                            1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                             

                                                            1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                             

                                                            1. What is the main conclusion from this study? The conclusion must be reduced.

                                                            International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                             

                                                            1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                              Dear Editor,

                                                              I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                               

                                                              A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                              B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                              1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                              2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                               

                                                              1. English should be improved throughout the article.
                                                              2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                              3. The major results and conclusions must be included in the abstract.
                                                              4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                              5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                              6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                               

                                                              1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                              Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                               

                                                              1. I have not found comparative between this study with other literatures.

                                                               

                                                              1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                              Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                               

                                                              1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                               

                                                              1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                               

                                                              1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                               

                                                              1. What is the main conclusion from this study? The conclusion must be reduced.

                                                              International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                               

                                                              1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                Dear Editor,

                                                                I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                 

                                                                A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                 

                                                                1. English should be improved throughout the article.
                                                                2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                3. The major results and conclusions must be included in the abstract.
                                                                4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                 

                                                                1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                 

                                                                1. I have not found comparative between this study with other literatures.

                                                                 

                                                                1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                 

                                                                1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                 

                                                                1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                 

                                                                1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                 

                                                                1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                 

                                                                1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                  Dear Editor,

                                                                  I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                   

                                                                  A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                  B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                   

                                                                  1. English should be improved throughout the article.
                                                                  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                  3. The major results and conclusions must be included in the abstract.
                                                                  4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                   

                                                                  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                  Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                   

                                                                  1. I have not found comparative between this study with other literatures.

                                                                   

                                                                  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                  Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                   

                                                                  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                   

                                                                  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                   

                                                                  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                   

                                                                  1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                  International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                   

                                                                  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                    Dear Editor,

                                                                    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                     

                                                                    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                     

                                                                    1. English should be improved throughout the article.
                                                                    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                    3. The major results and conclusions must be included in the abstract.
                                                                    4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                     

                                                                    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                     

                                                                    1. I have not found comparative between this study with other literatures.

                                                                     

                                                                    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                     

                                                                    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                     

                                                                    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                     

                                                                    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                     

                                                                    1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                     

                                                                    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                      Dear Editor,

                                                                      I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                       

                                                                      A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                      B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                      1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                      2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                       

                                                                      1. English should be improved throughout the article.
                                                                      2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                      3. The major results and conclusions must be included in the abstract.
                                                                      4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                      5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                      6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                       

                                                                      1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                      Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                       

                                                                      1. I have not found comparative between this study with other literatures.

                                                                       

                                                                      1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                      Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                       

                                                                      1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                       

                                                                      1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                       

                                                                      1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                       

                                                                      1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                      International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                       

                                                                      1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                        Dear Editor,

                                                                        I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                         

                                                                        A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                        B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                        1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                        2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                         

                                                                        1. English should be improved throughout the article.
                                                                        2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                        3. The major results and conclusions must be included in the abstract.
                                                                        4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                        5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                        6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                         

                                                                        1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                        Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                         

                                                                        1. I have not found comparative between this study with other literatures.

                                                                         

                                                                        1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                        Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                         

                                                                        1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                         

                                                                        1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                         

                                                                        1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                         

                                                                        1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                        International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                         

                                                                        1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                          Dear Editor,

                                                                          I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                           

                                                                          A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                          B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                          1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                          2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                           

                                                                          1. English should be improved throughout the article.
                                                                          2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                          3. The major results and conclusions must be included in the abstract.
                                                                          4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                          5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                          6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                           

                                                                          1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                          Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                           

                                                                          1. I have not found comparative between this study with other literatures.

                                                                           

                                                                          1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                          Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                           

                                                                          1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                           

                                                                          1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                           

                                                                          1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                           

                                                                          1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                          International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                           

                                                                          1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                            Dear Editor,

                                                                            I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                             

                                                                            A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                            B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                            1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                            2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                             

                                                                            1. English should be improved throughout the article.
                                                                            2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                            3. The major results and conclusions must be included in the abstract.
                                                                            4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                            5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                            6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                             

                                                                            1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                            Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                             

                                                                            1. I have not found comparative between this study with other literatures.

                                                                             

                                                                            1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                            Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                             

                                                                            1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                             

                                                                            1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                             

                                                                            1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                             

                                                                            1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                            International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                             

                                                                            1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                              Dear Editor,

                                                                              I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                               

                                                                              A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                              B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                              1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                              2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                               

                                                                              1. English should be improved throughout the article.
                                                                              2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                              3. The major results and conclusions must be included in the abstract.
                                                                              4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                              5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                              6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                               

                                                                              1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                              Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                               

                                                                              1. I have not found comparative between this study with other literatures.

                                                                               

                                                                              1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                              Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                               

                                                                              1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                               

                                                                              1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                               

                                                                              1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                               

                                                                              1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                              International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                               

                                                                              1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                Dear Editor,

                                                                                I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                 

                                                                                A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                 

                                                                                1. English should be improved throughout the article.
                                                                                2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                3. The major results and conclusions must be included in the abstract.
                                                                                4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                 

                                                                                1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                 

                                                                                1. I have not found comparative between this study with other literatures.

                                                                                 

                                                                                1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                 

                                                                                1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                 

                                                                                1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                 

                                                                                1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                 

                                                                                1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                 

                                                                                1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                  Dear Editor,

                                                                                  I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                   

                                                                                  A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                  B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                   

                                                                                  1. English should be improved throughout the article.
                                                                                  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                  3. The major results and conclusions must be included in the abstract.
                                                                                  4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                   

                                                                                  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                  Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                   

                                                                                  1. I have not found comparative between this study with other literatures.

                                                                                   

                                                                                  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                  Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                   

                                                                                  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                   

                                                                                  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                   

                                                                                  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                   

                                                                                  1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                  International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                   

                                                                                  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                    Dear Editor,

                                                                                    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                     

                                                                                    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                     

                                                                                    1. English should be improved throughout the article.
                                                                                    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                    3. The major results and conclusions must be included in the abstract.
                                                                                    4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                     

                                                                                    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                     

                                                                                    1. I have not found comparative between this study with other literatures.

                                                                                     

                                                                                    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                     

                                                                                    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                     

                                                                                    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                     

                                                                                    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                     

                                                                                    1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                     

                                                                                    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                      Dear Editor,

                                                                                      I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                       

                                                                                      A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                      B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                      1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                      2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                       

                                                                                      1. English should be improved throughout the article.
                                                                                      2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                      3. The major results and conclusions must be included in the abstract.
                                                                                      4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                      5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                      6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                       

                                                                                      1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                      Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                       

                                                                                      1. I have not found comparative between this study with other literatures.

                                                                                       

                                                                                      1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                      Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                       

                                                                                      1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                       

                                                                                      1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                       

                                                                                      1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                       

                                                                                      1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                      International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                       

                                                                                      1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                        Dear Editor,

                                                                                        I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                         

                                                                                        A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                        B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                        1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                        2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                         

                                                                                        1. English should be improved throughout the article.
                                                                                        2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                        3. The major results and conclusions must be included in the abstract.
                                                                                        4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                        5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                        6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                         

                                                                                        1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                        Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                         

                                                                                        1. I have not found comparative between this study with other literatures.

                                                                                         

                                                                                        1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                        Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                         

                                                                                        1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                         

                                                                                        1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                         

                                                                                        1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                         

                                                                                        1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                        International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                         

                                                                                        1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                          Dear Editor,

                                                                                          I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                           

                                                                                          A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                          B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                          1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                          2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                           

                                                                                          1. English should be improved throughout the article.
                                                                                          2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                          3. The major results and conclusions must be included in the abstract.
                                                                                          4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                          5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                          6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                           

                                                                                          1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                          Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                           

                                                                                          1. I have not found comparative between this study with other literatures.

                                                                                           

                                                                                          1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                          Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                           

                                                                                          1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                           

                                                                                          1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                           

                                                                                          1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                           

                                                                                          1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                          International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                           

                                                                                          1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                            Dear Editor,

                                                                                            I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                             

                                                                                            A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                            B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                            1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                            2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                             

                                                                                            1. English should be improved throughout the article.
                                                                                            2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                            3. The major results and conclusions must be included in the abstract.
                                                                                            4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                            5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                            6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                             

                                                                                            1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                            Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                             

                                                                                            1. I have not found comparative between this study with other literatures.

                                                                                             

                                                                                            1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                            Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                             

                                                                                            1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                             

                                                                                            1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                             

                                                                                            1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                             

                                                                                            1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                            International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                             

                                                                                            1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                              Dear Editor,

                                                                                              I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                               

                                                                                              A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                              B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                              1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                              2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                               

                                                                                              1. English should be improved throughout the article.
                                                                                              2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                              3. The major results and conclusions must be included in the abstract.
                                                                                              4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                              5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                              6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                               

                                                                                              1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                              Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                               

                                                                                              1. I have not found comparative between this study with other literatures.

                                                                                               

                                                                                              1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                              Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                               

                                                                                              1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                               

                                                                                              1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                               

                                                                                              1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                               

                                                                                              1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                              International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                               

                                                                                              1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                                Dear Editor,

                                                                                                I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                                 

                                                                                                A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                                B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                                1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                                2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                                 

                                                                                                1. English should be improved throughout the article.
                                                                                                2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                                3. The major results and conclusions must be included in the abstract.
                                                                                                4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                                5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                                6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                                 

                                                                                                1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                                Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                                 

                                                                                                1. I have not found comparative between this study with other literatures.

                                                                                                 

                                                                                                1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                                Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                                 

                                                                                                1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                                 

                                                                                                1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                                 

                                                                                                1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                                 

                                                                                                1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                                International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                                 

                                                                                                1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                                  Dear Editor,

                                                                                                  I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                                   

                                                                                                  A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                                  B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                                  1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                                  2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                                   

                                                                                                  1. English should be improved throughout the article.
                                                                                                  2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                                  3. The major results and conclusions must be included in the abstract.
                                                                                                  4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                                  5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                                  6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                                   

                                                                                                  1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                                  Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                                   

                                                                                                  1. I have not found comparative between this study with other literatures.

                                                                                                   

                                                                                                  1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                                  Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                                   

                                                                                                  1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                                   

                                                                                                  1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                                   

                                                                                                  1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                                   

                                                                                                  1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                                  International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                                   

                                                                                                  1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of drug.

                                                                                                    Dear Editor,

                                                                                                    I'm very glad to be the review of this paper (Manuscript Number: 1679912). Title: How does the long-time storage influence the physical stability and dissolution of bicalutamide from solid dispersions and minitablets? I hope from the authors of this paper to exploit the following note in order to correct the paper for the best form. I decided to accept this paper for the publishing in Process Journal as special Issues in MDPI Publication after major correction with following comments:

                                                                                                     

                                                                                                    A: I hope from the author of this paper to focus about the mathematical models to study the stability of amorphous drugs, because of the Mathematical models are an important tool to design pharmaceutical formulations, evaluate drug release processes in vitro and in vivo and, in general, come up with the optimal design for new systems. They allow the measurement of some important physical parameters (e.g., drug diffusion coefficient) and resort to model fitting on experimental release data.

                                                                                                    B: What are the types of drug release in this study? Such as; immediate release (IR), delayed release (DR), sustained release (SR), controlled release (CR), stimulus-sensitive release (SSR), and targeted release (TR).

                                                                                                    1. The drug can either be incorporated into nanoparticles by hydrogen bonding, ionic interaction, dipole interaction, physical entrapment (or encapsulation), precipitation, covalent bonding or be adsorbed to the surface. In most drug delivery systems, more than one loading mechanism is involved. What are the loading mechanism?
                                                                                                    2. The kinetics of drug release such as; The first order, Higuchi, Korsmeyer-Peppas, and Weibull kinetics models must be applied in this study.

                                                                                                     

                                                                                                    1. English should be improved throughout the article.
                                                                                                    2. I could not found a recognizing contribution in this paper, actually there are a plenty of results about this subject, but the authors were not focusing about the novelty or new information in this field from the papers references.
                                                                                                    3. The major results and conclusions must be included in the abstract.
                                                                                                    4. The title of the manuscript must be convenient or included the idea of the novelty.
                                                                                                    5. Explain in the introduction part the modern method with new carrier in drug delivery system which used in this field such as MCM-41, MCM-48 and SBA-15.
                                                                                                    6. Comparative between the characterization of the carrier such as; XRD, SEM, FTIR, BET surface area……etc. with the other carrier is found as follow: Journal of Molecular Structure 1260 (2022) 132879. doi: https://doi.org/10.1016/j.molstruc.2022.132879.

                                                                                                     

                                                                                                    1. The author must be explaining the type of loading in this study to know and study the stability of amorphous drugs. Is the loading was achieved by adsorption method. What about the isotherms of adsorption and kinetics?

                                                                                                    Chinese Journal of Chemical Engineering, Volume 36, August 2021, Pages 19-28. https://doi.org/10.1016/j.cjche.2020.07.031.

                                                                                                     

                                                                                                    1. I have not found comparative between this study with other literatures.

                                                                                                     

                                                                                                    1. The author must be explaining the role of functional group for prepared carrier to know and study the stability of amorphous drugs.

                                                                                                    Advanced Powder Technology 33 (2022) 103417. https://doi.org/10.1016/j.apt.2021.103417.

                                                                                                     

                                                                                                    1. The loading drug on the carrier is very important. I hope from the author of this paper explain that in details. Drug Delivery, 28 (1) (2021) 856–864. https://doi.org/10.1080/10717544.2021.1914778.

                                                                                                     

                                                                                                    1. The material must be appeared according the sequence XRD, BET surface area, SEM, FT-IR and TGA.

                                                                                                     

                                                                                                    1. The author must be clear the experimental steps and discuss the interfacial phenomena for this study. Desalination and Water Treatment 220 (2021) 130-141.

                                                                                                     

                                                                                                    1. What is the main conclusion from this study? The conclusion must be reduced.

                                                                                                    International Journal of Environmental Science and Technology, 2022, 19(3), pp. 1383–1392. https://doi.org/10.1007/s13762-021-03205-5.

                                                                                                     

                                                                                                    1. The surface area is very important. The author must be discussing this point in details to know and study the stability of amorphous drugs, because the surface area is very important factor increasing the adsorption rate and release of x.v

Author Response

Dear Reviewer, please see the attachement.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Seen

Reviewer 3 Report

The review is interesting to read and well organized. 

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