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Volume 12
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10.3390/pr12102108
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Fucosylated Chondroitin Sulfate from Bohadschia ocellata: Structure Analysis and Bioactivities

by
Pham Duc Thinh
1,2,*,
Hang Thi Thuy Cao
1,
Dinh Thanh Trung
1,
Duong Khanh Minh
2,
Thao Quyen Cao
3,
Tran Thi Thanh Van
1,
Anastasia O. Zueva
4,
Svetlana P. Ermakova
4 and
Thanh-Danh Nguyen
5
1
Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong, Nha Trang 650000, Vietnam
2
Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi 11300, Vietnam
3
Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea
4
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
5
Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1A, TL29, Thanh Loc Ward, District 12, Ho Chi Minh City 70000, Vietnam
*
Author to whom correspondence should be addressed.
Processes 2024, 12(10), 2108; https://doi.org/10.3390/pr12102108
Submission received: 9 September 2024 / Revised: 23 September 2024 / Accepted: 26 September 2024 / Published: 27 September 2024
(This article belongs to the Special Issue Phytochemicals: Extraction, Optimization, Identification, Biological Activities, and Applications in the Food, Nutraceutical, and Pharmaceutical Industries)
Versions Notes

Abstract

Fucosylated chondroitin sulfate (FCS) was prepared from Bohadschia ocellata using protease hydrolysis. The structural characteristics of FCS were confirmed through chemical composition analysis using FTIR spectroscopy, 1H NMR, and 13C NMR. FCS from B. ocellata (FCS-Bo) exhibited an average molecular weight of approximately 122 kDa. The biological activities of FCS-Bo, including anticoagulant, anti-cancer, and Protein Tyrosine Phosphatase 1B (PTP1B) inhibition, were evaluated. FCS-Bo displayed potent anticoagulant properties, markedly extending activated partial thromboplastin time, prothrombin time, and thrombin time when compared to the heparin control. In anti-cancer bioactivity research, FCS-Bo efficiently inhibited colony formation in the colon cancer cell lines HCT-116, HT-29, and DLD-1, achieving inhibition rates of up to 65%. Additionally, FCS-Bo exhibited significant inhibition of PTP1B, with an IC50 as low as 0.0326 µg/mL, suggesting its potential for improving insulin sensitivity and managing conditions such as type 2 diabetes and obesity.
Keywords: Bohadschia ocellata; fucosylated chondroitin sulfate; anticoagulant activity; anti-cancer activity; protein tyrosine phosphatase 1B Bohadschia ocellata; fucosylated chondroitin sulfate; anticoagulant activity; anti-cancer activity; protein tyrosine phosphatase 1B

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MDPI and ACS Style

Thinh, P.D.; Cao, H.T.T.; Trung, D.T.; Minh, D.K.; Cao, T.Q.; Van, T.T.T.; Zueva, A.O.; Ermakova, S.P.; Nguyen, T.-D. Fucosylated Chondroitin Sulfate from Bohadschia ocellata: Structure Analysis and Bioactivities. Processes 2024, 12, 2108. https://doi.org/10.3390/pr12102108

AMA Style

Thinh PD, Cao HTT, Trung DT, Minh DK, Cao TQ, Van TTT, Zueva AO, Ermakova SP, Nguyen T-D. Fucosylated Chondroitin Sulfate from Bohadschia ocellata: Structure Analysis and Bioactivities. Processes. 2024; 12(10):2108. https://doi.org/10.3390/pr12102108

Chicago/Turabian Style

Thinh, Pham Duc, Hang Thi Thuy Cao, Dinh Thanh Trung, Duong Khanh Minh, Thao Quyen Cao, Tran Thi Thanh Van, Anastasia O. Zueva, Svetlana P. Ermakova, and Thanh-Danh Nguyen. 2024. "Fucosylated Chondroitin Sulfate from Bohadschia ocellata: Structure Analysis and Bioactivities" Processes 12, no. 10: 2108. https://doi.org/10.3390/pr12102108

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