Next Article in Journal
The Whitening Efficacy of a Hydroxyapatite Toothpaste and a Blue Covarine Toothpaste: A Comparative In Vitro Study
Next Article in Special Issue
How Does Allergen Sensitization Affect Orthodontic Tooth Movement-Associated Phenomena? A Systematic Review of Animal Studies
Previous Article in Journal
The Use of Vacuum Plasma Surface Treatment to Improve the Hydrophilicity and Wettability of Bone Graft Substitutes and Resorbable Membranes: An In Vitro Study
Previous Article in Special Issue
Comparison of Side Effects Between Miniscrew-Assisted Rapid Palatal Expansion (MARPE) and Surgically Assisted Rapid Palatal Expansion (SARPE) in Adult Patients: A Scoping Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Dentistry Journal
Volume 13
Issue 4
10.3390/dj13040142
dentistry-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Microtomographic, Histomorphological, and Histomorphometric Analysis of Bone Healing in the Midpalatal Suture After Treatment with Isotretinoin

by
Maria Júlia Bento Martins Parreira
1,
Daniela Vieira Buchaim
2,3,4,
Ana Carolina Cestari Bighetti
1,
Marcos Antonio Girotto
5,
Miguel Ângelo de Marchi
6,
Dayane Maria Braz Nogueira
1,
Augusto Alberto Foggiato
7,
Juliana Zorzi Coléte
8,
Acácio Fuziy
9 and
Rogerio Leone Buchaim
2,10,*
1
Postgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, Brazil
2
Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science (FMVZ/USP), University of Sao Paulo, Sao Paulo 05508-270, Brazil
3
Anatomy Department, Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil
4
Multiprofessional Preceptorship for Undergraduate Health Studies, Faculty of Medicine of Bauru (FMBRU-USP), University of Sao Paulo, Bauru 17012-901, Brazil
5
Oral Health Coordination, Municipal Health Department, Marília 17501-002, Brazil
6
Dermatology Department, Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil
7
Department of Radiology, Pediatrics, and Orthodontics, State University of Northern Paraná (UENP), Jacarezinho 86400-000, Brazil
8
Department of Oral and Maxillofacial Surgery, Traumatology, and Stomatology, State University of Northern Paraná (UENP), Jacarezinho 86400-000, Brazil
9
Specialization Program in Orthodontics, Brazilian Dental Association (ABO), Goiânia 74325-110, Brazil
10
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, Brazil
*
Author to whom correspondence should be addressed.
Dent. J. 2025, 13(4), 142; https://doi.org/10.3390/dj13040142
Submission received: 9 February 2025 / Revised: 11 March 2025 / Accepted: 21 March 2025 / Published: 25 March 2025
(This article belongs to the Special Issue Current Research Topics in Orthodontics)
Browse Figures
Versions Notes

Abstract

Background/Objectives: Rapid palatal expansion is commonly used to correct maxillary deficiencies. However, medications like Isotretinoin may influence bone remodeling during treatment. Isotretinoin, a drug used to treat acne, was the focus of this study, which aimed to evaluate its effect on bone repair after rapid palatal suture expansion in rats. Methods: The sample consisted of 40 Wistar rats, divided into two groups: the control group (CG), subjected only to orthodontic movement, and the experimental isotretinoin group (IG), where movement occurred after drug administration. Periods of 0, 7, and 14 days after the installation of the orthodontic device were analyzed, with a force of 30 g applied in all groups using a steel spring. After euthanasia, the maxillae were removed and analyzed via Micro-CT, histologically, and histomorphometrically. Results: The results showed that the expander was effective in promoting the expansion of the palatal suture. After 14 days, the total expansion was 381% (CG) and 299% (IG); the percentage of vessels in the connective tissue increased by 145% in CG and 84% in IG; and bone formation in both groups occupied 52% of the expanded palatal suture. No significant differences were observed between the groups regarding collagen fiber formation. Conclusions: It was concluded that the daily administration of Isotretinoin at the standard dose for the treatment of severe acne does not cause significant alterations in the bone repair process following the opening of the median palatine suture in rats.
Keywords: isotretinoin; bone repair; bone; bone regeneration; palatal expansion technique; rats; retinoid; vitamin A; orthodontic appliance design; acne isotretinoin; bone repair; bone; bone regeneration; palatal expansion technique; rats; retinoid; vitamin A; orthodontic appliance design; acne

Share and Cite

MDPI and ACS Style

Parreira, M.J.B.M.; Buchaim, D.V.; Bighetti, A.C.C.; Girotto, M.A.; de Marchi, M.Â.; Nogueira, D.M.B.; Foggiato, A.A.; Coléte, J.Z.; Fuziy, A.; Buchaim, R.L. Microtomographic, Histomorphological, and Histomorphometric Analysis of Bone Healing in the Midpalatal Suture After Treatment with Isotretinoin. Dent. J. 2025, 13, 142. https://doi.org/10.3390/dj13040142

AMA Style

Parreira MJBM, Buchaim DV, Bighetti ACC, Girotto MA, de Marchi MÂ, Nogueira DMB, Foggiato AA, Coléte JZ, Fuziy A, Buchaim RL. Microtomographic, Histomorphological, and Histomorphometric Analysis of Bone Healing in the Midpalatal Suture After Treatment with Isotretinoin. Dentistry Journal. 2025; 13(4):142. https://doi.org/10.3390/dj13040142

Chicago/Turabian Style

Parreira, Maria Júlia Bento Martins, Daniela Vieira Buchaim, Ana Carolina Cestari Bighetti, Marcos Antonio Girotto, Miguel Ângelo de Marchi, Dayane Maria Braz Nogueira, Augusto Alberto Foggiato, Juliana Zorzi Coléte, Acácio Fuziy, and Rogerio Leone Buchaim. 2025. "Microtomographic, Histomorphological, and Histomorphometric Analysis of Bone Healing in the Midpalatal Suture After Treatment with Isotretinoin" Dentistry Journal 13, no. 4: 142. https://doi.org/10.3390/dj13040142

APA Style

Parreira, M. J. B. M., Buchaim, D. V., Bighetti, A. C. C., Girotto, M. A., de Marchi, M. Â., Nogueira, D. M. B., Foggiato, A. A., Coléte, J. Z., Fuziy, A., & Buchaim, R. L. (2025). Microtomographic, Histomorphological, and Histomorphometric Analysis of Bone Healing in the Midpalatal Suture After Treatment with Isotretinoin. Dentistry Journal, 13(4), 142. https://doi.org/10.3390/dj13040142

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop