Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
, Xiurou Meng 1,†, Yongkang Wang 2, Xueqin Shi 1, Tianyou Feng 1, Deyu Hu 1 and Yuping Zhang 1,*Round 1
Reviewer 1 Report
This paper reported dissipation and risk assessment of dimethacarb in rice with HPLC-MSMS. The content is very important to the related field. There are some points to be revised.
The ADI of dimethacarb is not established yet. But, authors assessed risk of this compound with the ADI of isoprocarb. Although the structure of isoprocarb is similar with dimethacarb, toxicity is not related with the structure. I recommend to use the lowest ADI from cabarmate insecticides for food safety, and rewirte this part.
Minor corrections are as follow.
2 page line 4, isoprocorb => isoprocarb
3page, delete 3,5-dimethylphenyl methylcarbamate and 3,4-dimethylphenyl methylcarbamate. These are already explained in the previous paragraph.
3page , in "Field trials" section. plot size is 30 m2 not 30 m2
4 page, line 6. pending analysis => until analysis
4 page, line 12. 1 ml => 1 mL
4 page, line 15. filter membrane to HPLC-MS/MS for analysis => mebrane filter to analyze with HPLC-MS/MS.
5 page, formula 3. lin2/kt => ln2/k
Author Response
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Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript entitled "Dynamics of Dissipation, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS / MS" reports a large study carried out with rice and its plant parts, planted in China.
Contribute with information relevant to sanitary control that serve as parameters for acceptance of the concentration levels of pesticides used.
The authors performed the necessary tests for the conclusions proposed in the manuscript. Analytical rigor in the revealed data is observed.
Author Response
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Author Response File: Author Response.pdf
Reviewer 3 Report
It is opinion of the reviewer that this paper needs several modifications/corrections. My individual comments are listed below.
The title – It should be “… Dimethylcarbamate …”.
Only one reference ([32]) was cited in Discussion.
47 – It should be “… pesticides such as dimethcarb … is to inhibit …”.
Fig. 3 & 3 – Significance of differences must be marked with letters.
Fig. 3 – The unit of “Intensity” should be added to description of the Y axis.
65/66 – It should be “high performance ….high performance”.
65/68 – What type of the HPLC columns were used?
89 – It should be “dimethylcarbone”.
147 – The centrifugation must be characterized by „x g” instead of „rpm”.
152 – It should be “Condition of an HPLC0MS/MS analysis”.
163 – It should be “resolution factor”.
188 – It should be “The degradation … was carried out.
208 – It should be “This article aimed …”.
211 – It should be “… a key …”.
231/233 – It should be In this work …(Fig. 3). C18 removes ….sterols.”.
231 and other lines – It should be “C18”.
The section of statistical analysis must be added to Methods.
Few abbreviations of journal titles must be corrected.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 3 Report
The authors corrected this paper properly taken under considerations all my comments. Therefore, I can accept it now.
