Intestinal Microecology of Mice Exposed to TiO2 Nanoparticles and Bisphenol A

Yang, Chen; Tan, Youlan; Li, Fengzhu; Wang, Hongbin; Lin, Ying; Lu, Fuping; Zhao, Huabing

doi:10.3390/foods11121696

Open AccessArticle

Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A

by

Chen Yang

¹,

Youlan Tan

¹,

Fengzhu Li

¹,

Hongbin Wang

^1,2,

Ying Lin

³,

Fuping Lu

^1,2 and

Huabing Zhao

^1,2,*

¹

College of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, China

²

Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300450, China

³

School of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, China

^*

Author to whom correspondence should be addressed.

Foods 2022, 11(12), 1696; https://doi.org/10.3390/foods11121696

Submission received: 22 April 2022 / Revised: 30 May 2022 / Accepted: 5 June 2022 / Published: 9 June 2022

(This article belongs to the Special Issue Environmentally Friendly Manufacturing of Food Additives and Functional Ingredients)

Download

Browse Figures

Versions Notes

Abstract

Exposure to titanium dioxide nanoparticles (TiO₂ NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO₂ NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO₂ NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO₂ NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO₂ NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO₂ NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota.

Keywords: TiO₂ NPs; BPA; 16S rDNA; faecal metabolomic

Share and Cite

MDPI and ACS Style

Yang, C.; Tan, Y.; Li, F.; Wang, H.; Lin, Y.; Lu, F.; Zhao, H. Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A. Foods 2022, 11, 1696. https://doi.org/10.3390/foods11121696

AMA Style

Yang C, Tan Y, Li F, Wang H, Lin Y, Lu F, Zhao H. Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A. Foods. 2022; 11(12):1696. https://doi.org/10.3390/foods11121696

Chicago/Turabian Style

Yang, Chen, Youlan Tan, Fengzhu Li, Hongbin Wang, Ying Lin, Fuping Lu, and Huabing Zhao. 2022. "Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A" Foods 11, no. 12: 1696. https://doi.org/10.3390/foods11121696

APA Style

Yang, C., Tan, Y., Li, F., Wang, H., Lin, Y., Lu, F., & Zhao, H. (2022). Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A. Foods, 11(12), 1696. https://doi.org/10.3390/foods11121696

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI