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Article

Food from Equids—Commercial Fermented Mare’s Milk (Koumiss) Products: Protective Effects against Alcohol Intoxication

1
Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China
2
Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China
3
Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Foods 2024, 13(15), 2344; https://doi.org/10.3390/foods13152344
Submission received: 29 June 2024 / Revised: 19 July 2024 / Accepted: 22 July 2024 / Published: 25 July 2024

Abstract

Fermented mare’s milk (koumiss), a traditional Central Asian dairy product derived from fermented mare’s milk, is renowned for its unique sour taste and texture. It has long been consumed by nomadic tribes for its nutritional and medicinal benefits. This study aimed to comprehensively analyze the protective effects of koumiss against alcohol-induced harm across behavioral, hematological, gastrointestinal, hepatic, and reproductive dimensions using a mouse model. Optimal intoxicating doses of alcohol and koumiss doses were determined, and their effects were explored through sleep tests and blood indicator measurements. Pretreatment with koumiss delayed inebriation, accelerated sobering, and reduced mortality in mice, mitigating alcohol’s impact on blood ethanol levels and various physiological parameters. Histopathological and molecular analyses further confirmed koumiss’s protective role against alcohol-induced damage in the liver, stomach, small intestine, and reproductive system. Transcriptomic studies on reproductive damage indicated that koumiss exerts its benefits by influencing mitochondrial and ribosomal functions and also shows promise in mitigating alcohol’s effects on the reproductive system. In summary, koumiss emerges as a potential natural agent for protection against alcohol-induced harm, opening avenues for future research in this field.
Keywords: alcohol-induced harm; koumiss; mitochondrial and ribosomal functions; mouse model; protective effects alcohol-induced harm; koumiss; mitochondrial and ribosomal functions; mouse model; protective effects

Share and Cite

MDPI and ACS Style

Du, M.; Liu, Y.; Cao, J.; Li, X.; Wang, N.; He, Q.; Zhang, L.; Zhao, B.; Dugarjaviin, M. Food from Equids—Commercial Fermented Mare’s Milk (Koumiss) Products: Protective Effects against Alcohol Intoxication. Foods 2024, 13, 2344. https://doi.org/10.3390/foods13152344

AMA Style

Du M, Liu Y, Cao J, Li X, Wang N, He Q, Zhang L, Zhao B, Dugarjaviin M. Food from Equids—Commercial Fermented Mare’s Milk (Koumiss) Products: Protective Effects against Alcohol Intoxication. Foods. 2024; 13(15):2344. https://doi.org/10.3390/foods13152344

Chicago/Turabian Style

Du, Ming, Yuanyi Liu, Jialong Cao, Xinyu Li, Na Wang, Qianqian He, Lei Zhang, Bilig Zhao, and Manglai Dugarjaviin. 2024. "Food from Equids—Commercial Fermented Mare’s Milk (Koumiss) Products: Protective Effects against Alcohol Intoxication" Foods 13, no. 15: 2344. https://doi.org/10.3390/foods13152344

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