C/EBPβ–TFAM-Mediated NLRP3 Inflammasome Activation Contributes to Arsenic-Induced Rat Kidney Injury
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Models of Sub-Chronic Arsenic Treatment
2.2. Sample Collection
2.3. Determination of Urine As
2.4. Determination of Kidney Function
2.5. HE Staining
2.6. Western Blot Analysis
2.7. IHC Analysis
2.8. Statistical Analysis
3. Results
3.1. As Treatment Induced Histopathological Structural Changes and Kidney Dysfunction
3.2. As Induced Inflammation in the Rat Kidney
3.3. As-Induced NLRP3 Inflammasome Activation in the Rat Kidney
3.4. C/EBPβ–TFAM-Mediated NLRP3 Inflammasome Activation May Contribute to As-Induced Kidney Injury
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Wu, Z.; Wang, W.; Zhu, K.; Luo, D.; Zhang, A. C/EBPβ–TFAM-Mediated NLRP3 Inflammasome Activation Contributes to Arsenic-Induced Rat Kidney Injury. Toxics 2023, 11, 668. https://doi.org/10.3390/toxics11080668
Wu Z, Wang W, Zhu K, Luo D, Zhang A. C/EBPβ–TFAM-Mediated NLRP3 Inflammasome Activation Contributes to Arsenic-Induced Rat Kidney Injury. Toxics. 2023; 11(8):668. https://doi.org/10.3390/toxics11080668
Chicago/Turabian StyleWu, Ziqin, Wenjuan Wang, Kai Zhu, Daopeng Luo, and Aihua Zhang. 2023. "C/EBPβ–TFAM-Mediated NLRP3 Inflammasome Activation Contributes to Arsenic-Induced Rat Kidney Injury" Toxics 11, no. 8: 668. https://doi.org/10.3390/toxics11080668