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Medicines, Volume 10, Issue 6

2023 June - 5 articles

Cover Story: The study aims to evaluate the antifungal activity of L. galangal rhizome and to develop a topical antifungal formulation. The dried, powdered rhizome of L. galangal was successively extracted with hexane, dichloromethane, ethyl acetate and methanol using Soxhlet extraction. The agar well diffusion method was used to assess the antifungal activity against C. albicans and A. niger. The most active hexane extract was used to prepare the cream. The antifungal activity was tested. Clotrimazole produced a larger zone of inhibition and dimethyl sulfoxide (DMSO) did not produce. The hexane extract was identified as the best extract with stronger antifungal activity against C. albicans and A. niger. Furthermore, its effect remained even when it was included in the formulation of an antifungal cream. The results of different physicochemical tests showed a stable and good appearance of the cream. View this paper

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Article

3 Citations

4,434 Views

10 Pages

Rhinosinusitis Treatment with Cineole: Patient-Reported Quality of Life Improvements from a Non-Interventional, Pharmacy-Based Survey

Nina Werkhäuser,
Ursula Pieper-Fürst,
Hacer Sahin,
Antonia Claas and
Ralph Mösges

Medicines2023, 10(6), 37;https://doi.org/10.3390/medicines10060037

19 June 2023

Background: Rhinosinusitis is commonly treated with decongestants, analgesics, and local corticosteroids. Phytotherapeutics are also utilised for symptomatic relief, including cineole, the main component of eucalyptus oil. Methods: The current non-in...

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Opinion

2 Citations

2,132 Views

8 Pages

Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer

Leonardo Marques da Fonseca,
Israel Diniz-Lima,
Marcos André Rodrigues da Costa Santos,
Tatiany Nunes Franklim,
Kelli Monteiro da Costa,
Ariely Costa dos Santos,
Alexandre Morrot,
Debora Decote-Ricardo,
Raphael do Carmo Valente and
Leonardo Freire-de-Lima
+ 2 authors

Medicines2023, 10(6), 36;https://doi.org/10.3390/medicines10060036

14 June 2023

Cancer cells are characterized by metabolic reprogramming, which enables their survival in of-ten inhospitable conditions. A very well-documented example that has gained attraction in re-cent years and is already considered a hallmark of transformed...

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Review

8 Citations

11,652 Views

32 Pages

Antiseizure Medication-Induced Alopecia: A Literature Review

Jamir Pitton Rissardo,
Ana Leticia Fornari Caprara,
Maritsa Casares,
Holly J. Skinner and
Umair Hamid

Medicines2023, 10(6), 35;https://doi.org/10.3390/medicines10060035

9 June 2023

Background: Adverse effects of antiseizure medications (ASMs) remain one of the major causes of non-adherence. Cosmetic side effects (CSEs) are among the most commonly reported side effects of ASMs. In this context, alopecia is one of the CSEs that h...

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Article

2 Citations

6,421 Views

12 Pages

Evaluation of Antifungal Activity of Languas galangal Rhizome and Development of a Topical Antifungal Cream

Lakshmi Reka,
Chamari Maheshika Godage,
Jayantha Wijayabandara and
Aravinda Siriwardhene

Medicines2023, 10(6), 34;https://doi.org/10.3390/medicines10060034

9 June 2023

Background: The rhizome of Languas galangal is traditionally used in Sri Lanka for the treatment of skin infections caused by fungi. The aim of the present study was to evaluate the antifungal activity of L. galangal rhizome and to develop a topical...

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Review

8 Citations

9,476 Views

13 Pages

Fluoroquinolone-Associated Movement Disorder: A Literature Review

Jamir Pitton Rissardo and
Ana Letícia Fornari Caprara

Medicines2023, 10(6), 33;https://doi.org/10.3390/medicines10060033

25 May 2023

Background: Fluoroquinolones (FQNs) are related to several central nervous system side effects. This review aims to evaluate the clinical-epidemiological profile, pathophysiological mechanisms, and management of FQNs-associated movement disorders (MD...

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