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Perspective

Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics

by
John R. Aggas
1,2,†,
Sara Abasi
1,3,†,
Carolyn Ton
4,5,
Sara Salehi
4,5,
Renee Liu
4,5,
Gerald Brandacher
5,6,
Warren L. Grayson
4,5,7,8,9,* and
Anthony Guiseppi-Elie
1,10,11,*
1
Bioelectronics, Biosensors and Biochips (C3B®), Department of Biomedical Engineering, Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA
2
Test Development, Roche Diagnostics, 9115 Hague Road, Indianapolis, IN 46256, USA
3
Media and Metabolism, Wildtype, Inc., 2325 3rd St., San Francisco, CA 94107, USA
4
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA
5
Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA
6
Department of Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21218, USA
7
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
8
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
9
Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA
10
Department of Cardiovascular Sciences, Houston Methodist Institute for Academic Medicine and Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA
11
ABTECH Scientific, Inc., Biotechnology Research Park, 800 East Leigh Street, Richmond, VA 23219, USA
 
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*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Bioengineering 2023, 10(4), 434; https://doi.org/10.3390/bioengineering10040434
Submission received: 6 February 2023 / Revised: 20 March 2023 / Accepted: 24 March 2023 / Published: 29 March 2023
(This article belongs to the Section Regenerative Engineering)
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Abstract

Vascularized composite allotransplantation addresses injuries to complex anatomical structures such as the face, hand, and abdominal wall. Prolonged static cold storage of vascularized composite allografts (VCA) incurs damage and imposes transportation limits to their viability and availability. Tissue ischemia, the major clinical indication, is strongly correlated with negative transplantation outcomes. Machine perfusion and normothermia can extend preservation times. This perspective introduces multiplexed multi-electrode bioimpedance spectroscopy (MMBIS), an established bioanalytical method to quantify the interaction of the electrical current with tissue components, capable of measuring tissue edema, as a quantitative, noninvasive, real-time, continuous monitoring technique to provide crucially needed assessment of graft preservation efficacy and viability. MMBIS must be developed, and appropriate models explored to address the highly complex multi-tissue structures and time-temperature changes of VCA. Combined with artificial intelligence (AI), MMBIS can serve to stratify allografts for improvement in transplantation outcomes.
Keywords: vascularized composite tissue allografts; edema; bioimpedance; transplantation; stratification vascularized composite tissue allografts; edema; bioimpedance; transplantation; stratification

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MDPI and ACS Style

Aggas, J.R.; Abasi, S.; Ton, C.; Salehi, S.; Liu, R.; Brandacher, G.; Grayson, W.L.; Guiseppi-Elie, A. Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics. Bioengineering 2023, 10, 434. https://doi.org/10.3390/bioengineering10040434

AMA Style

Aggas JR, Abasi S, Ton C, Salehi S, Liu R, Brandacher G, Grayson WL, Guiseppi-Elie A. Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics. Bioengineering. 2023; 10(4):434. https://doi.org/10.3390/bioengineering10040434

Chicago/Turabian Style

Aggas, John R., Sara Abasi, Carolyn Ton, Sara Salehi, Renee Liu, Gerald Brandacher, Warren L. Grayson, and Anthony Guiseppi-Elie. 2023. "Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics" Bioengineering 10, no. 4: 434. https://doi.org/10.3390/bioengineering10040434

APA Style

Aggas, J. R., Abasi, S., Ton, C., Salehi, S., Liu, R., Brandacher, G., Grayson, W. L., & Guiseppi-Elie, A. (2023). Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics. Bioengineering, 10(4), 434. https://doi.org/10.3390/bioengineering10040434

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