Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review
Abstract
:1. Introduction
2. Biomechanical Foundations of Mitral-Ventricular Interaction
2.1. Mitral Valve Modelling
2.2. The Physiologic Mitral–Ventricular Relationship
2.2.1. Mitral Valve Leaflets
2.2.2. Mitral Valve Annulus
2.2.3. Chordae Tendineae
2.2.4. Papillary Muscles and Adjacent Myocardium
3. Chronic Ischemic Mitral Regurgitation
3.1. The Ventricle Tethers the Valve
3.2. Annular Mechanics and Remodeling
3.3. Implications for Existing and Future Surgical and Interventional Approaches
4. Mitral Valve Prolapse
4.1. The Valve Pulls on the Ventricle
4.2. Surgical Repair Techniques
5. Knowledge Gaps
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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van Kampen, A.; Morningstar, J.E.; Goudot, G.; Ingels, N.; Wenk, J.F.; Nagata, Y.; Yaghoubian, K.M.; Norris, R.A.; Borger, M.A.; Melnitchouk, S.; et al. Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review. Bioengineering 2023, 10, 601. https://doi.org/10.3390/bioengineering10050601
van Kampen A, Morningstar JE, Goudot G, Ingels N, Wenk JF, Nagata Y, Yaghoubian KM, Norris RA, Borger MA, Melnitchouk S, et al. Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review. Bioengineering. 2023; 10(5):601. https://doi.org/10.3390/bioengineering10050601
Chicago/Turabian Stylevan Kampen, Antonia, Jordan E. Morningstar, Guillaume Goudot, Neil Ingels, Jonathan F. Wenk, Yasufumi Nagata, Koushiar M. Yaghoubian, Russell A. Norris, Michael A. Borger, Serguei Melnitchouk, and et al. 2023. "Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review" Bioengineering 10, no. 5: 601. https://doi.org/10.3390/bioengineering10050601