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Bioengineering
Volume 8
Issue 6
10.3390/bioengineering8060079
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Article

3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

by
Martyna Nizioł
1,
Justyna Paleczny
2,
Adam Junka
2,
Amin Shavandi
3,
Anna Dawiec-Liśniewska
4 and
Daria Podstawczyk
1,*
1
Department of Process Engineering and Technology of Polymer and Carbon Materials, Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, 50-373 Wroclaw, Poland
2
Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, 50-556 Wroclaw, Poland
3
BioMatter Research Unit-Biomass and Biomaterials (3BIO-BioMatter), Université Libre de Bruxelles, Avenue F.D. Roosevelt, 50, CP 165/61, 1050 Brussels, Belgium
4
Department of Advanced Material Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, M. Smoluchowskiego 25, 50-372 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Bioengineering 2021, 8(6), 79; https://doi.org/10.3390/bioengineering8060079
Submission received: 8 April 2021 / Revised: 29 May 2021 / Accepted: 5 June 2021 / Published: 8 June 2021
(This article belongs to the Special Issue 3D Printing of Functional Biomaterials and Nanocomposites)
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Abstract

Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), methylcellulose (MC) that is laden with a mixture of octenidine dihydrochloride and 2-phenoxyethanol (Octenisept®, OCT) possess accurate printability and shape fidelity. This study also provides the protocol of ink’s use for the 3D printing of hydrogel scaffolds. The hydrogel’s physicochemical properties and drug release profiles from the hydrogel specimens to the external solution have been determined at two temperatures (20 and 37 °C). The release test showed a sustained OCT delivery into ultrapure water and the PBS solution. The temperature-responsive hydrogel exhibited antimicrobial activity against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa and demonstrated non-cytotoxicity towards fibroblasts. The thermoresponsive behavior along with biocompatibility, antimicrobial activity, and controlled drug release make this hydrogel a promising class of materials for wound dressing applications.
Keywords: stimuli-responsive; wound patch; biocompatible; additive manufacturing; printability stimuli-responsive; wound patch; biocompatible; additive manufacturing; printability

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MDPI and ACS Style

Nizioł, M.; Paleczny, J.; Junka, A.; Shavandi, A.; Dawiec-Liśniewska, A.; Podstawczyk, D. 3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications. Bioengineering 2021, 8, 79. https://doi.org/10.3390/bioengineering8060079

AMA Style

Nizioł M, Paleczny J, Junka A, Shavandi A, Dawiec-Liśniewska A, Podstawczyk D. 3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications. Bioengineering. 2021; 8(6):79. https://doi.org/10.3390/bioengineering8060079

Chicago/Turabian Style

Nizioł, Martyna, Justyna Paleczny, Adam Junka, Amin Shavandi, Anna Dawiec-Liśniewska, and Daria Podstawczyk. 2021. "3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications" Bioengineering 8, no. 6: 79. https://doi.org/10.3390/bioengineering8060079

APA Style

Nizioł, M., Paleczny, J., Junka, A., Shavandi, A., Dawiec-Liśniewska, A., & Podstawczyk, D. (2021). 3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications. Bioengineering, 8(6), 79. https://doi.org/10.3390/bioengineering8060079

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