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Bioengineering, Volume 8, Issue 6

2021 June - 15 articles

Cover Story: Alveolar bone defects may have different causes, such as cleft palate. The correction of those defects requires regenerative procedures. The iliac crest bone graft remains the gold standard, although other approaches exist, such as bone morphogenic protein 2 (BMP-2). In this umbrella review, we compare the effectiveness of all of the current approaches for bone regeneration to repair bone defects in non-syndromic patients with cleft palate. Iliac crest bone graft and BMP-2 present the best results and provide similar outcomes regarding bone volume, filling, and height. View this paper.
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Articles (15)

  • Article
  • Open Access
2 Citations
3,915 Views
12 Pages

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class

  • Cristina Lopez,
  • Jose Luis Holgado,
  • Raquel Cortes,
  • Inma Sauri,
  • Antonio Fernandez,
  • Jose Miguel Calderon,
  • Julio Nuñez and
  • Josep Redon

Artificial Intelligence is creating a paradigm shift in health care, with phenotyping patients through clustering techniques being one of the areas of interest. Objective: To develop a predictive model to classify heart failure (HF) patients accordin...

  • Article
  • Open Access
17 Citations
4,804 Views
19 Pages

The use of artificial neural networks (ANNs) is a great contribution to medical studies since the application of forecasting concepts allows for the analysis of future diseases propagation. In this context, this paper presents a study of the new coro...

  • Article
  • Open Access
6 Citations
4,865 Views
14 Pages

Strategy for Managing Industrial Anaerobic Sludge through the Heterotrophic Cultivation of Chlorella sorokiniana: Effect of Iron Addition on Biomass and Lipid Production

  • Esteban Charria-Girón,
  • Vanessa Amazo,
  • Daniela De Angulo,
  • Eliana Hidalgo,
  • María Francisca Villegas-Torres,
  • Frank Baganz and
  • Nelson. H. Caicedo Ortega

Microalgae provides an alternative for the valorization of industrial by-products, in which the nutritional content varies substantially and directly affects microalgae system performance. Herein, the heterotrophic cultivation of Chlorella sorokinian...

  • Article
  • Open Access
3 Citations
4,445 Views
11 Pages

adipoSIGHT in Therapeutic Response: Consequences in Osteosarcoma Treatment

  • Banani Kundu,
  • Virginia Brancato,
  • Joaquim Oliveira,
  • Vitor M. Correlo,
  • Rui L. Reis and
  • Subhas C. Kundu

Chemotherapeutic resistance is a major problem in effective cancer treatment. Cancer cells engage various cells or mechanisms to resist anti-cancer therapeutics, which results in metastasis and the recurrence of disease. Considering the cellular hete...

  • Systematic Review
  • Open Access
24 Citations
6,490 Views
31 Pages

Cardiovascular disease is currently the top global cause of death, however, research into new therapies is in decline. Tissue engineering is a solution to this crisis and in combination with the use of carbon nanotubes (CNTs), which have drawn recent...

  • Communication
  • Open Access
17 Citations
6,004 Views
13 Pages

Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors

  • Marina Llenas,
  • Roberto Paoli,
  • Natalia Feiner-Gracia,
  • Lorenzo Albertazzi,
  • Josep Samitier and
  • David Caballero

Tumor vessel-on-a-chip systems have attracted the interest of the cancer research community due to their ability to accurately recapitulate the multiple dynamic events of the metastatic cascade. Vessel-on-a-chip microfluidic platforms have been less...

  • Article
  • Open Access
67 Citations
10,696 Views
18 Pages

3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

  • Martyna Nizioł,
  • Justyna Paleczny,
  • Adam Junka,
  • Amin Shavandi,
  • Anna Dawiec-Liśniewska and
  • Daria Podstawczyk

Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), met...

  • Article
  • Open Access
7 Citations
5,569 Views
13 Pages

At-Line Reversed Phase Liquid Chromatography for In-Process Monitoring of Inclusion Body Solubilization

  • Julian Ebner,
  • Diana Humer,
  • Robert Klausser,
  • Viktor Rubus,
  • Reinhard Pell,
  • Oliver Spadiut and
  • Julian Kopp

Refolding is known as the bottleneck in inclusion body (IB) downstream processing in the pharmaceutical industry: high dilutions leading to large operating volumes, slow refolding kinetics and low refolding yields are only a few of the problems that...

  • Article
  • Open Access
8 Citations
4,516 Views
16 Pages

Different Microfluidic Environments for In Vitro Testing of Lipid Nanoparticles against Osteosarcoma

  • Oihane Mitxelena-Iribarren,
  • Sara Lizarbe-Sancha,
  • Jay Campisi,
  • Sergio Arana and
  • Maite Mujika

The use of lipid nanoparticles as biodegradable shells for controlled drug delivery shows promise as a more effective and targeted tumor treatment than traditional treatment methods. Although the combination of target therapy with nanotechnology crea...

  • Review
  • Open Access
8 Citations
6,785 Views
18 Pages

Regenerative Strategies in Cleft Palate: An Umbrella Review

  • Inês Francisco,
  • Anabela Baptista Paula,
  • Bárbara Oliveiros,
  • Maria Helena Fernandes,
  • Eunice Carrilho,
  • Carlos Miguel Marto and
  • Francisco Vale

(1) Background: Alveolar bone defects or decreased alveolar bone height and width may have different causes, such as cleft palate. Regenerative procedures in oro-dental defects are challenging due to anatomical factors and the distinct cell populatio...

  • Article
  • Open Access
4 Citations
5,229 Views
16 Pages

Modeling Focused-Ultrasound Response for Non-Invasive Treatment Using Machine Learning

  • Tariq Mohammad Arif,
  • Zhiming Ji,
  • Md Adilur Rahim and
  • Bharath Babu Nunna

The interactions between body tissues and a focused ultrasound beam can be evaluated using various numerical models. Among these, the Rayleigh–Sommerfeld and angular spectrum methods are considered to be the most effective in terms of accuracy. Howev...

  • Article
  • Open Access
12 Citations
5,515 Views
15 Pages

Fibrin Glue Implants Seeded with Dental Pulp and Periodontal Ligament Stem Cells for the Repair of Periodontal Bone Defects: A Preclinical Study

  • Natella I. Enukashvily,
  • Julia A. Dombrovskaya,
  • Anastasia V. Kotova,
  • Natalia Semenova,
  • Irina Karabak,
  • Roman E. Banashkov,
  • Dmitry Baram,
  • Tatiana Paderina,
  • Stanislav S. Bilyk and
  • Alexey V. Silin
  • + 4 authors

A technology to create a cell-seeded fibrin-based implant matching the size and shape of bone defect is required to create an anatomical implant. The aim of the study was to develop a technology of cell-seeded fibrin gel implant creation that has the...

  • Article
  • Open Access
5 Citations
4,347 Views
26 Pages

Thermo-Viscoelastic Response of Protein-Based Hydrogels

  • Aleksey D. Drozdov and
  • Jesper deClaville Christiansen

Because of the bioactivity and biocompatibility of protein-based gels and the reversible nature of bonds between associating coiled coils, these materials demonstrate a wide spectrum of potential applications in targeted drug delivery, tissue enginee...

  • Article
  • Open Access
23 Citations
5,437 Views
14 Pages

In-House, Fast FDM Prototyping of a Custom Cutting Guide for a Lower-Risk Pediatric Femoral Osteotomy

  • Leonardo Frizziero,
  • Gian Maria Santi,
  • Christian Leon-Cardenas,
  • Giampiero Donnici,
  • Alfredo Liverani,
  • Paola Papaleo,
  • Francesca Napolitano,
  • Curzio Pagliari,
  • Giovanni Luigi Di Gennaro and
  • Paola Zarantonello
  • + 3 authors

Three-dimensional printed custom cutting guides (CCGs) are becoming more and more investigated in medical literature, as a patient-specific approach is often desired and very much needed in today’s surgical practice. Three-dimensional printing applic...

  • Article
  • Open Access
16 Citations
4,635 Views
11 Pages

Blood Glucose Level Forecasting on Type-1-Diabetes Subjects during Physical Activity: A Comparative Analysis of Different Learning Techniques

  • Benedetta De Paoli,
  • Federico D’Antoni,
  • Mario Merone,
  • Silvia Pieralice,
  • Vincenzo Piemonte and
  • Paolo Pozzilli

Background: Type 1 Diabetes Mellitus (T1DM) is a widespread chronic disease in industrialized countries. Preventing blood glucose levels from exceeding the euglycaemic range would reduce the incidence of diabetes-related complications and improve the...

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Bioengineering - ISSN 2306-5354