3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering
Abstract
:1. Introduction
2. Material and Methods
2.1. Materials
2.2. Preparation of the Solutions for 3D Printing
2.3. Fabrication of the Scaffolds with the 3D Printing Process
2.4. Characterization of the Scaffolds
In Vitro Release Studies
3. Results and Discussions
3.1. Fourier Transform Infrared Spectroscopy (FTIR)
3.2. Morphological Characterizations of the Scaffolds
3.3. Mechanical Properties of the Scaffolds
3.4. Thermal Behaviors of the Scaffolds
3.5. Antibacterial Activity Results of the J Added 3D-Printed Scaffolds
3.6. Biocompatibility Properties of the Scaffolds
3.7. In Vitro Relase Studies
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Scaffolds | Tensile Strength (MPa) | Elongation at Break (%) | Elastic Modulus (MPa) |
---|---|---|---|
25% PCL | 1.1 ± 0.07 | 97.6 ± 4.2 | 1.14 |
25% PCL/1.25 J | 1.15 ± 0.28 | 224.7 ± 29.9 | 0.51 |
25% PCL/2.5 J | 0.95 ± 0.21 | 263.54 ± 29.5 | 0.36 |
25% PCL/5 J | 1.20 ± 0.28 | 262.5 ± 40.2 | 0.45 |
25% PCL/7.5 J | 1.01 ± 0.25 | 240.50 ± 17.5 | 0.42 |
25% PCL/10 J | 0.90 ± 0.12 | 360.45 ± 11.8 | 0.25 |
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Ayran, M.; Dirican, A.Y.; Saatcioglu, E.; Ulag, S.; Sahin, A.; Aksu, B.; Croitoru, A.-M.; Ficai, D.; Gunduz, O.; Ficai, A. 3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering. Bioengineering 2022, 9, 427. https://doi.org/10.3390/bioengineering9090427
Ayran M, Dirican AY, Saatcioglu E, Ulag S, Sahin A, Aksu B, Croitoru A-M, Ficai D, Gunduz O, Ficai A. 3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering. Bioengineering. 2022; 9(9):427. https://doi.org/10.3390/bioengineering9090427
Chicago/Turabian StyleAyran, Musa, Akif Yahya Dirican, Elif Saatcioglu, Songul Ulag, Ali Sahin, Burak Aksu, Alexa-Maria Croitoru, Denisa Ficai, Oguzhan Gunduz, and Anton Ficai. 2022. "3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering" Bioengineering 9, no. 9: 427. https://doi.org/10.3390/bioengineering9090427