Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Anaesthesia and Semen Collection
2.3. Semen Collection and Evaluation
2.4. Plasma Sample Analysis
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Parameters | T0 | T20 | T30 | T40 | T50 | T60 | T75 | T90 |
---|---|---|---|---|---|---|---|---|
HR (beats/min) | 191.2 ± 16.8 | 101.1 ± 15.1 * | 105.7 ± 15.4 * | 109.6 ± 16.4 * | 110.6 ± 11.1 * | 105.3 ± 13.8 * | 105.4 ± 9.5 * | 115.7 ± 12.7 * |
fR (breaths/min) | 25.1 ± 12.6 | 44.2 ± 19.9 | 36.3 ± 10.5 | 40 ± 12.8 | 44.1 ± 19.7 | 35.1 ± 8.6 | 33.6 ± 10.5 | 26.1 ± 4.9 |
SpO2 | 98.3 ± 2.1 | 97.9 ± 1.6 | 99.3 ± 0.5 | 99.5 ± 0.7 | 97.25 ± 2.9 | 97.7 ± 0.6 | 98.2 ± 0.7 |
Parameters | Values (median and range) | IQR |
---|---|---|
Time to reach peak concentration (minutes) | 40 (20–90) | 20–75 |
Peak concentration (ng/mL) | 32.8 (26.8–51.2) | 28.5–37.5 |
Area under the time-concentration curve (ng minute/mL) | 2240 (1759–3340) | 1967.6–2646.3 |
Volume of distribution (mL/kg) | 3724.2 (2431.5–4806.4) | 2584.6–4712.7 |
Apparent clearance (mL/kg/minute) | 11.9 (0.7–43.8) | 6.9–25.9 |
Mean residence time (minutes) | 50.8 (46.1–55.8) | 48–52.8 |
Time Points | Plasmatic Concentration (ng/mL) |
---|---|
0 | 0,0 (0–0) |
20 | 27.9 (17–50.3) |
30 | 28.2 (22–41.6) |
40 | 28.7 (19.6–39.9) |
50 | 28.8 (19.4–51.2) |
60 | 28.5 (18.6–47.4) |
75 | 28.6 (20.1–43.4) |
90 | 27.7 (16.5–42.9) |
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Romagnoli, N.; Lambertini, C.; Zambelli, D.; Cunto, M.; Ballotta, G.; Barbarossa, A. Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats. Vet. Sci. 2020, 7, 17. https://doi.org/10.3390/vetsci7010017
Romagnoli N, Lambertini C, Zambelli D, Cunto M, Ballotta G, Barbarossa A. Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats. Veterinary Sciences. 2020; 7(1):17. https://doi.org/10.3390/vetsci7010017
Chicago/Turabian StyleRomagnoli, Noemi, Carlotta Lambertini, Daniele Zambelli, Marco Cunto, Giulia Ballotta, and Andrea Barbarossa. 2020. "Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats" Veterinary Sciences 7, no. 1: 17. https://doi.org/10.3390/vetsci7010017