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Review

Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

by
Gareth Zigui Lim
1,
Jonathan Yexian Lai
1,
Christopher Ying Hao Seet
1,
Carol Huilian Tham
1,
Narayanaswamy Venketasubramanian
2,
Benjamin Yong Qiang Tan
3,4,
Mingxue Jing
3,4,
Joshua Yee Peng Yeo
3,4,
May Zin Myint
3,4,
Ching-Hui Sia
4,5,
Hock Luen Teoh
3,4,
Vijay Kumar Sharma
3,4,
Bernard Poon Lap Chan
3,4,
Cunli Yang
3,6,
Andrew Makmur
3,6,
Shao Jin Ong
3,6 and
Leonard Leong Litt Yeo
3,6,*
1
Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore
2
Raffles Neuroscience Centre, Raffles Hospital, Singapore 188770, Singapore
3
Division of Neurology, Department of Medicine, National University Health System, Singapore 119228, Singapore
4
Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore
5
Department of Cardiology, National University Heart Center, Singapore 119228, Singapore
6
Department of Diagnostic Imaging, National University Health System, Singapore 119228, Singapore
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2023, 10(12), 499; https://doi.org/10.3390/jcdd10120499
Submission received: 10 November 2023 / Revised: 2 December 2023 / Accepted: 15 December 2023 / Published: 18 December 2023
(This article belongs to the Section Stroke and Cerebrovascular Disease)
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Abstract

Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last two years, four randomised controlled trials have been published on this topic—RESCUE-Japan LIMIT, ANGEL-ASPECT, SELECT2 and TENSION, with overall results showing that EVT improves functional and neurological outcomes compared to medical management alone. This review aims to summarise the recent evidence presented by these four trials and highlight some of the limitations in our current understanding of this topic.
Keywords: ischaemic stroke; endovascular treatment; radiology; CT; MRI; acute; large infarcts ischaemic stroke; endovascular treatment; radiology; CT; MRI; acute; large infarcts

Share and Cite

MDPI and ACS Style

Lim, G.Z.; Lai, J.Y.; Seet, C.Y.H.; Tham, C.H.; Venketasubramanian, N.; Tan, B.Y.Q.; Jing, M.; Yeo, J.Y.P.; Myint, M.Z.; Sia, C.-H.; et al. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. J. Cardiovasc. Dev. Dis. 2023, 10, 499. https://doi.org/10.3390/jcdd10120499

AMA Style

Lim GZ, Lai JY, Seet CYH, Tham CH, Venketasubramanian N, Tan BYQ, Jing M, Yeo JYP, Myint MZ, Sia C-H, et al. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. Journal of Cardiovascular Development and Disease. 2023; 10(12):499. https://doi.org/10.3390/jcdd10120499

Chicago/Turabian Style

Lim, Gareth Zigui, Jonathan Yexian Lai, Christopher Ying Hao Seet, Carol Huilian Tham, Narayanaswamy Venketasubramanian, Benjamin Yong Qiang Tan, Mingxue Jing, Joshua Yee Peng Yeo, May Zin Myint, Ching-Hui Sia, and et al. 2023. "Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials" Journal of Cardiovascular Development and Disease 10, no. 12: 499. https://doi.org/10.3390/jcdd10120499

APA Style

Lim, G. Z., Lai, J. Y., Seet, C. Y. H., Tham, C. H., Venketasubramanian, N., Tan, B. Y. Q., Jing, M., Yeo, J. Y. P., Myint, M. Z., Sia, C.-H., Teoh, H. L., Sharma, V. K., Chan, B. P. L., Yang, C., Makmur, A., Ong, S. J., & Yeo, L. L. L. (2023). Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. Journal of Cardiovascular Development and Disease, 10(12), 499. https://doi.org/10.3390/jcdd10120499

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