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Review

Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review

by
Emily Chesshyre
1,2,*,
Eva Wooding
1,2,
Emily Sey
1 and
Adilia Warris
1,3
1
MRC Centre for Medical Mycology, Department of Biosciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QD, UK
2
Department of Paediatrics, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, UK
3
Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK
*
Author to whom correspondence should be addressed.
J. Fungi 2025, 11(3), 210; https://doi.org/10.3390/jof11030210
Submission received: 27 January 2025 / Revised: 25 February 2025 / Accepted: 7 March 2025 / Published: 9 March 2025
(This article belongs to the Special Issue Fungal Infections in Non-neutropenic Patients)
Versions Notes

Abstract

Cystic fibrosis is a severe, inherited, life-limiting disorder, and over half of those living with CF are children. Persistent airway infection and inflammation, resulting in progressive lung function decline, is the hallmark of this disorder. Aspergillus colonization and infection is a well-known complication in people with CF and can evolve in a range of Aspergillus disease phenotypes, including Aspergillus bronchitis, fungal sensitization, and allergic bronchopulmonary aspergillosis (ABPA). Management strategies for children with CF are primarily aimed at preventing lung damage and lung function decline caused by bacterial infections. The role of Aspergillus infections is less understood, especially during childhood, and therefore evidence-based diagnostic and treatment guidelines are lacking. This narrative review summarizes our current understanding of the impact of Aspergillus on the airways of children and young people with CF.
Keywords: Aspergillus; pediatrics; cystic fibrosis; CFTR; allergic bronchopulmonary aspergillosis Aspergillus; pediatrics; cystic fibrosis; CFTR; allergic bronchopulmonary aspergillosis

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MDPI and ACS Style

Chesshyre, E.; Wooding, E.; Sey, E.; Warris, A. Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review. J. Fungi 2025, 11, 210. https://doi.org/10.3390/jof11030210

AMA Style

Chesshyre E, Wooding E, Sey E, Warris A. Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review. Journal of Fungi. 2025; 11(3):210. https://doi.org/10.3390/jof11030210

Chicago/Turabian Style

Chesshyre, Emily, Eva Wooding, Emily Sey, and Adilia Warris. 2025. "Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review" Journal of Fungi 11, no. 3: 210. https://doi.org/10.3390/jof11030210

APA Style

Chesshyre, E., Wooding, E., Sey, E., & Warris, A. (2025). Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review. Journal of Fungi, 11(3), 210. https://doi.org/10.3390/jof11030210

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