Is ß-d-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection?
Abstract
:1. Introduction
2. Patients and Methods
2.1. Study Design
2.2. Study Population
2.3. Data Collection
2.4. (1,3)-ß-d-glucan Assays
2.5. Yeast Peritoneal Culture
2.6. Endpoints
2.7. Statistical Analysis
3. Results
3.1. Study Population
3.2. Primary and Secondary Endpoints
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Yeast Negative Peritoneal Culture (n = 46) | Yeast Positive Peritoneal Culture (n = 19) | p Value | |
---|---|---|---|
Age (years) | 69 [59–73] | 62 [59–71] | 0.42 |
Charlson score | 5.0 [3.5–7.0] | 5.0 [4.0–6.5] | 0.83 |
Sex, male | 25 (53.2%) | 14 (73.7%) | 0.21 |
SAPS2 score | 65 [51–74] | 66 [64–78] | 0.48 |
SOFA score | 14.0 [11.5–16.0] | 15.0 [11.5–16.0] | 0.29 |
Community IAI | 16 (34.0%) | 5 (26.3%) | 0.65 |
Generalized IAI | 33 (70.2%) | 15 (78.9%) | 0.68 |
Upper gastro-intestinal tract location | 14 (29.8%) | 10 (52.6%) | 0.35 |
MAP (mmHg) | 82 [70–90] | 77 [74–88] | 0.42 |
HR (bpm) | 100 [85–123] | 103 [90–114] | 0.97 |
Mechanical ventilation | 43 (91.5%) | 17 (89.5%) | 0.99 |
Procalcitonin (µg.L−1) | 3.6 [0.8–21.0] | 4.9 [0.9–25.3] | 0.89 |
CRP (mg.L−1) | 221 [153–299] | 150 [52–322] | 0.23 |
Yeast Negative Peritoneal Culture (n = 46) | Yeast Positive Peritoneal Culture (n = 19) | p Value | |
---|---|---|---|
Duration of catecholamine use (days) | 3 [2–5] | 5 [3–9] | 0.005 |
Duration of MV (days) | 3 [1–6] | 6 [4–16.5] | 0.001 |
Success rate at EOT | 18 (39.1%) | 3 (15.8%) | 0.085 |
Mortality at day 28 | 10 (21.7%) | 4 (21.5%) | 0.95 |
Mortality at hospital discharge | 14 (30.4%) | 5 (26.3%) | 0.74 |
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Dupont, H.; Malaquin, S.; Villeret, L.; Macq, P.-Y.; Ammenouche, N.; Tinturier, F.; Diouf, M.; Rumbach, M.; Chouaki, T. Is ß-d-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? J. Fungi 2022, 8, 487. https://doi.org/10.3390/jof8050487
Dupont H, Malaquin S, Villeret L, Macq P-Y, Ammenouche N, Tinturier F, Diouf M, Rumbach M, Chouaki T. Is ß-d-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? Journal of Fungi. 2022; 8(5):487. https://doi.org/10.3390/jof8050487
Chicago/Turabian StyleDupont, Hervé, Stéphanie Malaquin, Léonie Villeret, Pierre-Yves Macq, Nacim Ammenouche, François Tinturier, Momar Diouf, Matthieu Rumbach, and Taieb Chouaki. 2022. "Is ß-d-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection?" Journal of Fungi 8, no. 5: 487. https://doi.org/10.3390/jof8050487