Research Progress in the Multilayer Hydrogels
Abstract
:1. Introduction
2. Preparation Methods and Mechanisms of the Multilayer Hydrogels
2.1. LBL Assembling Methods for Multilayer Hydrogels
2.1.1. LBL by Chemical Crosslinking
2.1.2. LBL by Ion Crosslinking
2.1.3. LBL by Electrostatic Interaction
2.1.4. LBL through Acid-Base Neutralization
2.1.5. LBL by Compound Methods
2.2. Non-LBL Methods for Multilayer Hydrogels
2.2.1. New Concept Welding
2.2.2. Metal Ions Modulation
3. Achievements and Practical Applications of Multilayer Hydrogels
3.1. Drug and Bioactive Substances Delivery
3.2. Cell Encapsulation (Carrier or Bioreactors) and Bacteria Delivery
3.3. Cartilage Repair
3.4. Medical Dressings or Coatings
3.5. Other Fields
4. Conclusions and Prospects
Author Contributions
Funding
Conflicts of Interest
References
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Drug Carriers | Drug Species | Release Pathways | Advantages | Reference |
---|---|---|---|---|
Poly(methacrylic acid)/poly(N-vinylpyrrolidone) multilayer hydrogel capsules | Nucleic acids | Ultrasound-triggered release | Higher effective loading capacity and controlled delivery of sensitive biomolecules | [53] |
Poly(N-vinylcaprolactam) multilayer hydrogels | Sodium diclofenac | Increase in temperature | Multiple drug delivery | [54] |
Chitosan multilayer hydrogel capsules | Doxorubicin | Adjustment of pH | Significant inhibition of the burst release and good biocompatibility, | [55] |
Polycarboxymethyl-β-cyclodextrin (polyCM-β-CD)/polyetherimide (PEI) multilayer | Ofloxacin | Adjustment of pH | Controllable release in different media | [56] |
Poly(methacrylic acid) (PMAA) multilayer hydrogel cubes | 7-(benzylamino)-3,4-dihydro-pyrrolo[4,3,2-de]quinolin-8(1H)-one | Redox-triggered release | Long-term storage, combination of well-regulated drug release and shape-modulated drug delivery | [57] |
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Jin, L.; Xu, J.; Xue, Y.; Zhang, X.; Feng, M.; Wang, C.; Yao, W.; Wang, J.; He, M. Research Progress in the Multilayer Hydrogels. Gels 2021, 7, 172. https://doi.org/10.3390/gels7040172
Jin L, Xu J, Xue Y, Zhang X, Feng M, Wang C, Yao W, Wang J, He M. Research Progress in the Multilayer Hydrogels. Gels. 2021; 7(4):172. https://doi.org/10.3390/gels7040172
Chicago/Turabian StyleJin, Lu, Jia Xu, Youcai Xue, Xinjiang Zhang, Mengna Feng, Chengshuang Wang, Wei Yao, Jinshan Wang, and Meng He. 2021. "Research Progress in the Multilayer Hydrogels" Gels 7, no. 4: 172. https://doi.org/10.3390/gels7040172