Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation
Abstract
:1. Introduction
2. Results and Discussion
2.1. Preparation of CS/β-CDcPAa Hydrogels
2.2. FTIR Analysis
2.3. Sol–Gel Analysis
2.4. Porosity Study
2.5. Thermogravimetric Analysis (TGA)
2.6. Powder X-ray Diffraction (PXRD) Analysis
2.7. Scanning Electron Microscopy (SEM)
2.8. Dynamic Swelling Studies
2.9. Polymer Volume Fraction
2.10. Drug Loading Analysis
2.11. Dissolution Studies
2.12. Kinetic Modeling
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. Preparation of CS/β-CDcPAa Hydrogels
4.3. Fourier Transform Infrared Spectroscopy (FTIR)
4.4. Sol–Gel Analysis
4.5. Porosity Study
4.6. Thermogravimetric Analysis (TGA)
4.7. Powder X-ray Diffraction (PXRD) Analysis
4.8. Scanning Electron Microscopy (SEM)
4.9. Dynamic Swelling Studies
4.10. Polymer Volume Fraction
4.11. Drug Loading Analysis
4.12. Dissolution Studies
4.13. Kinetic Modeling
4.14. Statistical Analysis
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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F. Code | Polymer (CS) g/100 g | Polymer (β-CD) g/100 g | Monomer (Aa) g/100 g | Polymer Volume Fraction | |
---|---|---|---|---|---|
pH 1.2 | pH 7.4 | ||||
F-1 | 0.25 | 0.50 | 30 | 0.300 | 0.083 |
F-2 | 0.50 | 0.50 | 30 | 0.282 | 0.077 |
F-3 | 0.75 | 0.50 | 30 | 0.271 | 0.073 |
F-4 | 0.50 | 0.25 | 30 | 0.304 | 0.086 |
F-5 | 0.50 | 0.50 | 30 | 0.282 | 0.077 |
F-6 | 0.50 | 0.75 | 30 | 0.267 | 0.070 |
F-7 | 0.50 | 0.50 | 25 | 0.308 | 0.093 |
F-8 | 0.50 | 0.50 | 30 | 0.282 | 0.077 |
F-9 | 0.50 | 0.50 | 35 | 0.263 | 0.066 |
Formulation Code | Sol | Gel | Drug Loaded (mg)/400 mg of Dry Gel | |
---|---|---|---|---|
Fraction | Fraction | |||
% | % | Weight Method | Extraction Method | |
F-1 | 10.60 | 89.40 | 125.32 ± 0.94 | 123.90 ± 0.98 |
F-2 | 09.21 | 90.79 | 132.63 ± 1.04 | 131.48 ± 0.94 |
F-3 | 08.72 | 91.28 | 137.28 ± 0.98 | 136.12 ± 1.04 |
F-4 | 11.52 | 88.48 | 121.84 ± 1.08 | 119.73 ± 0.91 |
F-5 | 09.21 | 90.79 | 132.63 ± 1.04 | 131.48 ± 0.94 |
F-6 | 07.90 | 92.10 | 140.87 ± 0.97 | 138.11 ± 1.05 |
F-7 | 11.80 | 88.20 | 114.54 ± 1.07 | 113.25 ± 0.97 |
F-8 | 09.21 | 90.79 | 132.63 ± 1.04 | 131.48 ± 0.94 |
F-9 | 08.94 | 91.06 | 144.82 ± 1.04 | 143.51 ± 1.14 |
F. Code | Zero Order | First Order | Higuchi | Korsmeyer-Peppas | |
---|---|---|---|---|---|
r2 | r2 | r2 | r2 | n | |
F-1 | 0.9364 | 0.9912 | 0.9876 | 0.9848 | 0.5470 |
F-2 | 0.9636 | 0.9974 | 0.9890 | 0.9753 | 0.5228 |
F-3 | 0.9598 | 0.9864 | 0.9740 | 0.9823 | 0.6054 |
F-4 | 0.9312 | 0.9853 | 0.9065 | 0.9739 | 0.5993 |
F-5 | 0.9636 | 0.9974 | 0.9890 | 0.9753 | 0.5228 |
F-6 | 0.9512 | 0.9932 | 0.9910 | 0.9810 | 0.6183 |
F-7 | 0.9765 | 0.9880 | 0.9612 | 0.9636 | 0.6310 |
F-8 | 0.9636 | 0.9974 | 0.9890 | 0.9753 | 0.5228 |
F-9 | 0.9390 | 0.9781 | 0.9543 | 0.9584 | 0.5864 |
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Suhail, M.; Shao, Y.-F.; Vu, Q.L.; Wu, P.-C. Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation. Gels 2022, 8, 155. https://doi.org/10.3390/gels8030155
Suhail M, Shao Y-F, Vu QL, Wu P-C. Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation. Gels. 2022; 8(3):155. https://doi.org/10.3390/gels8030155
Chicago/Turabian StyleSuhail, Muhammad, Yu-Fang Shao, Quoc Lam Vu, and Pao-Chu Wu. 2022. "Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation" Gels 8, no. 3: 155. https://doi.org/10.3390/gels8030155