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Tropical Medicine and Infectious Disease, Volume 9, Issue 7

2024 July - 28 articles

Cover Story: A difficult disease to diagnose, leptospirosis has a wide spectrum of clinical presentations, including life-threatening ones. Fresh water exposure coupled with skin injury or immersion can lead to disease, which puts flood victims, agricultural workers, military members, and recreational tourists at risk. Climate change should increase disease incidence, suggesting many people at risk would benefit from preventive measures such as pre- or post-exposure antibiotic chemoprophylaxis. Eight clinical trials and three meta-analyses have evaluated prophylaxis and failed to show a substantial benefit. Our review assessed strengths and weaknesses of previous trials and described flaws in trial design or conduct. Based on our analysis, we suggest how future trials may be better constructed to answer this important question. View this paper
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Articles (28)

  • Review
  • Open Access
23 Citations
5,593 Views
25 Pages

An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018–2023)

  • Federica Frasca,
  • Leonardo Sorrentino,
  • Matteo Fracella,
  • Alessandra D’Auria,
  • Eleonora Coratti,
  • Luca Maddaloni,
  • Ginevra Bugani,
  • Massimo Gentile,
  • Alessandra Pierangeli and
  • Carolina Scagnolari
  • + 1 author

In recent decades, increases in temperature and tropical rainfall have facilitated the spread of mosquito species into temperate zones. Mosquitoes are vectors for many viruses, including West Nile virus (WNV) and dengue virus (DENV), and pose a serio...

  • Brief Report
  • Open Access
1 Citations
1,712 Views
4 Pages

Impact on Aedes aegypti Mosquitoes Exposed to Honey-Impregnated Flinders Technology Associates (FTA®) Cards

  • Amandine Guidez,
  • Albin Fontaine,
  • Arnaud Cannet,
  • Isabelle Dusfour,
  • Romain Girod and
  • Sébastien Briolant

Programs to control viruses transmitted by mosquitoes requires the implementation of surveillance tools. Over the past decade, Flinders Technology Associates (FTA®) cards, which preserve nucleic acids, have emerged as an innovating surveillance s...

  • Article
  • Open Access
3 Citations
2,574 Views
10 Pages

The Diagnostic Challenge of Cystic Echinococcosis in Humans: First Assessment of Underreporting Rates in Mongolia

  • Bolor Bold,
  • Christian Schindler,
  • Uranshagai Narankhuu,
  • Agiimaa Shagj,
  • Erdenebileg Bavuujav,
  • Sonin Sodov,
  • Tsogbadrakh Nyamdorj and
  • Jakob Zinsstag

Cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, is significantly underreported in Mongolia due to geographical remoteness, a lack of early diagnostics, and poor clinical management. This study aimed to provide a mor...

  • Article
  • Open Access
8 Citations
3,285 Views
10 Pages

Adolescents and young adults living with HIV (AYLHIV) in sub-Saharan Africa experience poorer HIV outcomes than adults, including lower ART adherence and virologic suppression. They also have high rates of unprotected sex, increasing the risk of adve...

  • Article
  • Open Access
2 Citations
4,317 Views
18 Pages

Rabies Realities: Navigating Barriers to Rabies Control in Rural Zambia—A Case Study of Manyinga and Mwansabombwe Districts

  • Muma Chipo Misapa,
  • Eugene C. Bwalya,
  • Ladslav Moonga,
  • Josiah Zimba,
  • Emmanuel S. Kabwali,
  • Mwenya Silombe,
  • Edgar Chilanzi Mulwanda,
  • Christopher Mulenga,
  • Martin C. Simuunza and
  • Walter Muleya
  • + 2 authors

Rabies persists as a longstanding issue in Zambia, despite being preventable. The current control measures, including dog vaccination, population control, and movement restriction, guided by ‘The Control of Dogs Act Chapter 247 of the Laws of Z...

  • Article
  • Open Access
1,889 Views
13 Pages

Effectiveness of Three Sampling Approaches for Optimizing Mapping and Preventive Chemotherapy against Schistosoma mansoni in the Western Part of Côte d’Ivoire

  • Jean-Baptiste K. Sékré,
  • Mamadou Ouattara,
  • Nana R. Diakité,
  • Fidèle K. Bassa,
  • Rufin K. Assaré,
  • Jules N. Kouadio,
  • Gaoussou Coulibaly,
  • Agodio Loukouri,
  • Mathieu N. Orsot and
  • Eliézer K. N’Goran
  • + 1 author

The elimination of schistosomiasis as a public health problem by 2030 is one of the main goals put forth in the World Health Organization’s roadmap for neglected tropical diseases. This study aimed to compare different sampling approaches to gu...

  • Article
  • Open Access
3 Citations
2,723 Views
11 Pages

The Comprehensive Management of Patients with Rhino-Orbito-Cerebral Mucormycosis; A Perspective from Antifungal Treatment to Prosthetic Rehabilitation: A Descriptive Cohort Study

  • Angélica Julián Castrejón,
  • Rosa Marene Hernández Martínez,
  • Diana Rivero Méndez,
  • Israel Nayensei Gil Velázquez,
  • Juan Heriberto Rodríguez Piña,
  • Juan Manuel Salgado Camacho,
  • Nicolás Teyes Calva,
  • Sayuri I. Espíndola Chavarría,
  • Patricia A. Meza-Meneses and
  • Carlos Alberto Castro-Fuentes

Surgical intervention is a key element in the management of patients diagnosed with mucormycosis. A retrospective cohort study was carried out, in which patients with a proven diagnosis of mucormycosis were evaluated over a period of 10 years, accord...

  • Article
  • Open Access
1 Citations
1,513 Views
8 Pages

Optimizing Trichiasis Case Finding to Attain the Elimination of Trachoma as a Public Health Problem

  • Joy Shu’aibu,
  • Grace Ajege,
  • Caleb Mpyet,
  • Michael Dejene,
  • Sunday Isiyaku,
  • Abubakar Tafida,
  • Michaela Kelly,
  • Innocent Emereuwa and
  • Paul Courtright

Background: As national trachoma programmes increase efforts to reduce the burden of trachomatous trichiasis (TT), TT case finding and referral are critical public health programme components. Our research aimed to explore the most effective and effi...

  • Opinion
  • Open Access
2 Citations
1,926 Views
8 Pages

Generally, human rights documents are to be applied universally. However, certain groups are identified for special treatment due to vulnerabilities faced; these are often referred to as vulnerable groups or populations. While human rights literature...

  • Article
  • Open Access
2,507 Views
13 Pages

(1) Background and rationale: To validate the reported therapeutic coverage, a lymphatic filariasis post-mass drug administration (MDA) campaign survey was conducted in the Lukonga health zone from 10 June to 15 July 2023. (2) Materials and methods:...

  • Article
  • Open Access
1 Citations
2,255 Views
13 Pages

CD4 count recovery is the main goal for an HIV patient who initiated ART. Early ART initiation in HIV patients can help restore immune function more effectively, even when they have reached an advanced stage. Some patients may respond positively to A...

  • Article
  • Open Access
2 Citations
1,909 Views
11 Pages

Epidemiological Characteristics and Spatiotemporal Patterns of Visceral Leishmaniasis in Xinjiang, China, during 2004–2021

  • Jiangshan Zhao,
  • Yue Zhang,
  • Haiting Zhang,
  • Shuo Wang,
  • Haibo He,
  • Guangzhong Shi,
  • Wumaier Maimaitijiang,
  • Yanyan Hou,
  • Ling Zhang and
  • Jianping Cao
  • + 2 authors

The spread of visceral leishmaniasis (VL), a serious global zoonotic parasitic disease, is mostly under control; however, several cases have been reported in recent decades in Xinjiang, China. This study aimed to analyze the epidemiological status an...

  • Article
  • Open Access
3 Citations
3,116 Views
10 Pages

16S rDNA Sequencing for Bacterial Identification in Preterm Infants with Suspected Early-Onset Neonatal Sepsis

  • Sergio Agudelo-Pérez,
  • A. Melissa Moreno,
  • Juliana Martínez-Garro,
  • Jorge Salazar,
  • Ruth Lopez,
  • Mateo Perdigón and
  • Ronald Peláez

Background: The high prevalence of suspected early-onset neonatal sepsis among preterm infants leads to immediate antibiotic administration upon admission. Notably, most blood cultures for suspected early-onset neonatal sepsis do not yield a causativ...

  • Article
  • Open Access
4 Citations
2,402 Views
11 Pages

Detection and Serological Evidence of European Bat Lyssavirus 1 in Belgian Bats between 2016 and 2018

  • Inne Nauwelaers,
  • Claudia Van den Eynde,
  • Sanne Terryn,
  • Bob Vandendriessche,
  • Wout Willems,
  • Daan Dekeukeleire and
  • Steven Van Gucht

Lyssaviruses are neurotropic viruses capable of inducing fatal encephalitis. While rabies virus has been successfully eradicated in Belgium, the prevalence of other lyssaviruses remains uncertain. In this study, we conducted a survey on live animals...

  • Article
  • Open Access
3 Citations
3,315 Views
13 Pages

A Qualitative Insight into Pre-Departure Orientation Training for Aspiring Nepalese Migrant Workers

  • Pramod Regmi,
  • Nirmal Aryal,
  • Edwin van Teijlingen,
  • Radheshyam Krishna KC,
  • Manish Gautam and
  • Sanju Maharjan

Pre-departure orientation training (PDOT) can help equip aspiring migrant workers with skills and knowledge to mitigate vulnerabilities throughout their migration journey, including health. In Nepal, PDOT has been mandatory since 2004 for migrant wor...

  • Article
  • Open Access
2 Citations
2,917 Views
11 Pages

High Frequency of Deletions in the pfhrp2 and pfhrp3 Genes of Plasmodium falciparum in the Middle Rio Negro Region of the Brazilian Amazon

  • Daniela Romero Bally,
  • Simone da Silva Santos,
  • Diego Calafate Arregue,
  • Mariana Kelly de Mattos and
  • Martha C. Suárez-Mutis

Several countries are reporting natural populations of P. falciparum with deletions in the pfhrp2/3 genes that can lead to false-negative results in rapid diagnostic tests. To investigate the prevalence of deletion in the pfhrp2/3 genes in the Rio Ne...

  • Review
  • Open Access
3 Citations
6,630 Views
9 Pages

Leptospirosis is a neglected tropical disease that remains potentially life threatening and hard to diagnose. Climate change combined with overlapping reservoir and human habitats will likely lead to increasing incidence, outbreaks, and mortality in...

  • Article
  • Open Access
2 Citations
3,140 Views
13 Pages

To ascertain the incidence trends of scrub typhus in the Chungcheong region, we analyzed the epidemiological survey information of 14,379 cases of scrub typhus reported to the integrated disease health management system of the Korea Centers for Disea...

  • Article
  • Open Access
2 Citations
1,738 Views
9 Pages

Clinical Prediction Rules for In-Hospital Mortality Outcome in Melioidosis Patients

  • Sunee Chayangsu,
  • Chusana Suankratay,
  • Apichat Tantraworasin and
  • Jiraporn Khorana

Background: Melioidosis, a disease induced by Burkholderia pseudomallei, poses a significant health threat in tropical areas where it is endemic. Despite the availability of effective treatments, mortality rates remain notably elevated. Many risk fac...

  • Article
  • Open Access
3 Citations
3,072 Views
14 Pages

Experimental Granulomatous Amebic Encephalitis Caused by Acanthamoeba castellanii

  • Samuel da Luz Borges,
  • Eberson da Silva de Macedo,
  • Felipe Alexandre Vinagre da Silva,
  • Brenda Jaqueline de Azevedo Ataíde,
  • Nívia de Souza Franco Mendes,
  • Adelaide da Conceição Fonseca Passos,
  • Suellen Alessandra Soares de Moraes,
  • Anderson Manoel Herculano,
  • Karen Renata Herculano Matos Oliveira and
  • Evander de Jesus Oliveira Batista
  • + 2 authors

Acanthamoeba genus can affect humans with diseases such as granulomatous amebic encephalitis (GAE), a highly lethal neuroinfection. Several aspects of the disease still need to be elucidated. Animal models of GAE have advanced our knowledge of the di...

  • Article
  • Open Access
2 Citations
3,717 Views
12 Pages

Challenges of Screening and Investigations of Contacts of Patients with Tuberculosis in Oyo and Osun States, Nigeria

  • Aderonke Agbaje,
  • Patrick Dakum,
  • Olugbenga Daniel,
  • Anyaike Chukwuma,
  • Obioma Chijoke-Akaniro,
  • Evaezi Okpokoro,
  • Samuel Akingbesote,
  • Christian Anyomi,
  • Adekola Adekunle and
  • Ademola Adelekan
  • + 6 authors

Tuberculosis (TB) remains a significant public health challenge in Nigeria, with high rates of transmission and low case detection rates. This paper presents the challenges of screening and investigation of contacts of patients with TB in Oyo and Osu...

  • Article
  • Open Access
3 Citations
2,984 Views
13 Pages

One Health Approach to Toxoplasmosis: Owner and Dog Seropositivity as Spatial Indicators of Risk Areas for Acquired, Gestational and Congenital Transmission

  • Natacha Sohn-Hausner,
  • Ricardo Guedes Correa,
  • Louise Bach Kmetiuk,
  • Evelyn Cristine da Silva,
  • Gustavo Nunes de Moraes,
  • Gabrielle dos Santos Rocha,
  • Helio Langoni and
  • Alexander Welker Biondo

Background: Toxoplasmosis has been of public health concern due to direct associations with socioeconomic vulnerability and inadequate living conditions. Methods: Accordingly, the present study aimed to assess antibodies against T. gondii, historical...

  • Article
  • Open Access
1 Citations
3,113 Views
13 Pages

Evaluation of Bait Acceptance and Immune Response in Local Dogs during an Oral Rabies Vaccination Field Study in Morocco

  • Nadia Aboulfidaa,
  • Florence Cliquet,
  • Emmanuelle Robardet,
  • Sami Darkaoui,
  • Marine Wasniewski,
  • Christian Kaiser,
  • Katharina Bobe,
  • Ad Vos and
  • Ouafaa Fassi Fihri

The objective of this study was to evaluate the bait preference of three selected bait types by local dogs and the induced immunogenicity of the oral rabies vaccine strain SPBN GASGAS in Morocco. The vaccine strain, combined with different bait types...

  • Article
  • Open Access
2 Citations
3,807 Views
12 Pages

Consistency of Multi-Month Antiretroviral Therapy Dispensing and Association with Viral Load Coverage among Pediatric Clients Living with HIV in Mozambique

  • Ivete Meque,
  • Nicole Herrera,
  • Michelle M. Gill,
  • Rui Guilaze,
  • Amancio Nhangave,
  • Jaciara Mussá,
  • Nilesh Bhatt,
  • Mahoudo Bonou and
  • Lauren Greenberg

With the increase in uptake of multi-month antiretroviral therapy dispensing (MMD) for children, little is known about consistency of MMD receipt over time and its association with virological outcomes. This analysis aims to assess the uptake of 3-mo...

  • Article
  • Open Access
2 Citations
2,531 Views
16 Pages

Identification and Functional Implications of the E5 Oncogene Polymorphisms of Human Papillomavirus Type 16

  • Antônio Humberto P. da Silva-Júnior,
  • Ruany Cristyne de Oliveira Silva,
  • Ana Pavla A. Diniz Gurgel,
  • Marconi Rêgo Barros-Júnior,
  • Kamylla Conceição Gomes Nascimento,
  • Daffany Luana Santos,
  • Lindomar J. Pena,
  • Rita de Cássia Pereira Lima,
  • Marcus Vinicius de Aragão Batista and
  • Antonio Carlos de Freitas
  • + 1 author

The persistence of the human papillomavirus type 16 (HPV16) infection on the cervical epithelium contributes to the progression of cervical cancer. Studies have demonstrated that HPV16 genetic variants may be associated with different risks of develo...

  • Article
  • Open Access
1 Citations
2,204 Views
11 Pages

Heat shock protein 16-kDa (HSP 16-kDa) is essential for the survival of Mycobacterium tuberculosis (M. tuberculosis) during the latent period; hence, a peptide–MHC presentation of HSP 16-kDa could be a potential diagnostic and therapeutic targe...

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Trop. Med. Infect. Dis. - ISSN 2414-6366