Cardiovascular Circulatory System and Left Carotid Model: A Fractional Approach to Disease Modeling
, Cristina Nuevo-Gallardo 1,*, Inés Tejado 1, Javier Fernández-Portales 2, Juan Francisco Ortega-Morán 3, J. Blas Pagador 3 and Blas M. Vinagre 1Round 1
Reviewer 1 Report
In the paper “Cardiovascular circulatory system and left carotid model. A fractional approach to disease modeling” the authors focused on presenting and describing
1) an improved electrical model of the cardiovascular system and
2) the fractional computation approach for cardiovascular diseases.
Considering the objectives of this paper, I don’t feel that the section Cardiovascular system has a real contribution. Moreover, there are few sub-section in which there is a misapprehension of the cardiac revolution. Furthermore, I would like the authors to revise very carefully the description of the Frank-Starling’s law and how the heart adapt to different conditions (only if this description has real contribution to the aims of the paper).From a hemodynamic point of view, the carotid artery stenosis should not be seen as a pure stenosis as in the case of leaflet stenosis. In the majority of the clinical scenarios, the etiology of the stenosis is represented by plaque atherosclerosis during which all the vessel properties are changed together with the internal diameter and blood flow hemodynamics through it. In my opinion, there is too little data obtained in their model to support the translation to medical data as the authors claim.
Author Response
Please find attached the response to the reviewer's comments.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The authors' research with titled "Cardiovascular circulatory system and left carotid model. A fractional approach to disease modeling" reported an augmented electrical model of the cardiovascular system that extends the conventional models to the left common carotid artery motivated by the high mortality rate produced by atherosclerosis disease in this blood vessel; and discussed a fractional behavioral approach to describe different diseases through a cardiovascular system model. From a clinical cardio-oncology point of view, the thorough article is well-organized, scientific sound with novality.
Author Response
Please find attached the response to the reviewer's comments.
Author Response File: Author Response.pdf
Reviewer 3 Report
The authors have developed an augmented electrical model of the cardiovascular system that extends the classic Windkessel models to the left common carotid artery. These models are validated by clinical indices of cardiovascular waveform and experimental data of pressure. They also attempted to model different cardiac function by using PV loop concept.
Overall, the paper is well written and provides important information to the researchers in cardiovascular biomechanics.
Author Response
Please find attached the response to the reviewer's comments.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
I don't have any other comments. The article is suitable now for publication.
