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4 pages, 168 KB

Open AccessEditorial

Abstracts of the 4th International Electronic Conference on Cancers (IECC2024): Insights into Cancer Metastasis, Biomarkers, Microenvironment, Immunotherapy, Pathophysiology, and Prevention

by Angeliki Magklara, Shinji Kawabata, Alfredo Conti and Vasso Apostolopoulos

Proceedings 2024, 100(1), 25; https://doi.org/10.3390/proceedings2024100025 - 18 Jun 2024

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Abstract

The 4th International Electronic Conference on Cancers (IECC 2024), organized by the MDPI journal Cancers, was an online event held on 6–8 March 2024 [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

Research

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1 pages, 125 KB

Open AccessAbstract

Hidden Gems in the Genome: Pseudogenes Unleashing Revolution in Hepatocellular Carcinoma Detection and Therapy

by Kritika Chugh

Proceedings 2024, 100(1), 1; https://doi.org/10.3390/proceedings2024100001 - 27 Mar 2024

Viewed by 995

Abstract

Hepatocellular Carcinoma (HCC), a formidable global health challenge, continues to claim numerous lives due to its asymptomatic nature in the early stages and limited treatment options. In this ever-evolving landscape of cancer research, pseudogenes, once relegated to the genetic sidelines as ‘non-functional’, have [...] Read more.

Hepatocellular Carcinoma (HCC), a formidable global health challenge, continues to claim numerous lives due to its asymptomatic nature in the early stages and limited treatment options. In this ever-evolving landscape of cancer research, pseudogenes, once relegated to the genetic sidelines as ‘non-functional’, have emerged as intriguing players. Contrary to their historical dismissal, pseudogenes are now recognized for their intricate roles in modulating gene expression and contributing to the complex molecular milieu of cancer. This comprehensive review delves into the uncharted territory of pseudogenes and their potential to revolutionize HCC detection and treatment. From deciphering the molecular connections between pseudogenes and HCC to exploring their utility as diagnostic biomarkers, prognostic indicators, and therapeutic targets, this article aims to solve the enigma of pseudogenes in hepatocellular carcinoma. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 129 KB

Open AccessAbstract

Pulmonary Tuberculosis: A Comorbidity or Misdiagnosis of Primary Lung Cancer in Africa?

by Tinashe Adrian Mazhindu, Ntokozo Ndlovu, Edith Matsikidze, Shirley Chibonda and Webster Kadzatsa

Proceedings 2024, 100(1), 2; https://doi.org/10.3390/proceedings2024100002 - 12 Apr 2024

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Abstract

Background: Globally, over 2 million new cases of lung cancer are diagnosed annually, representing about 11% of all cancers [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 134 KB

Open AccessAbstract

Exploring BNCT as a Novel Approach for Metastatic Spinal Tumor Management

by Yoshiki Fujikawa, Shinji Kawabata, Kohei Tsujino, Ryo Kayama, Hideki Kashiwagi, Yusuke Fukuo, Ryo Hiramatsu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Toshihiro Takami and Masahiko Wanibuchi

Proceedings 2024, 100(1), 3; https://doi.org/10.3390/proceedings2024100003 - 27 Mar 2024

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Abstract

[Background] Boron neutron capture therapy (BNCT) is a particle beam therapy that enables the precise targeting of tumors at the cellular level [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 147 KB

Open AccessAbstract

Development of Synergetic Combinations of a Novel Apoptosis Inducer with AKT and Hsp90 Selective Inhibitors Targeting Hormone-Sensitive and Hormone-Resistant Breast Cancer Cells

by Diana I. Salnikova, Stepan K. Krymov, Danila V. Sorokin, Fedor B. Bogdanov, Olga E. Andreeva, Alvina I. Khamidullina, Andrey E. Shchekotikhin and Alexander M. Scherbakov

Proceedings 2024, 100(1), 4; https://doi.org/10.3390/proceedings2024100004 - 27 Mar 2024

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Abstract

Introduction: The design and development of antitumor compounds based on an isatin core led to the synthesis of 1-substituted isatin-5-sulfonamides with potent antiproliferative activity [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 149 KB

Open AccessAbstract

Aberrantly Expressed Long Non-Coding RNAS and mRNAS in Breast Cancer and Their Interaction

by Elena Filippova, Svetlana Lukina, Irina Pronina, Alexey Burdenny, Tatiana Kazubskaya, Vitaly Loginov and Eleonora Braga

Proceedings 2024, 100(1), 5; https://doi.org/10.3390/proceedings2024100005 - 27 Mar 2024

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Abstract

According to the latest global statistics for 2020, breast cancer (BC) has taken first place in the incidence of epithelial tumors, ahead of lung cancer, and is the main cause of mortality from cancer pathology among women around the world [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

1 pages, 124 KB

Open AccessAbstract

The Suppression of Medulloblastoma Cell Migration Using Clinically Significant Doses of Simvastatin through Mevalonate Pathway Targeting

by Charley Comer and Maria Victoria Niklison-Chirou

Proceedings 2024, 100(1), 6; https://doi.org/10.3390/proceedings2024100006 - 27 Mar 2024

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Abstract

Aims: Medulloblastoma (MBs), the most prevalent malignant paediatric brain tumour, exhibits distinct subgroups—Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3), and Group 4 (G4)—and each is characterized by unique molecular signatures and clinical outcomes [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 126 KB

Open AccessAbstract

Development of Letrozole-Loaded Magnetic Nanoemulsion Used for Breast Cancer Treatment

by Dharshana Karthikeyan, Latha Subbiah and Selvamani Palanisamy

Proceedings 2024, 100(1), 7; https://doi.org/10.3390/proceedings2024100007 - 27 Mar 2024

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Abstract

Introduction: Emulsions are attractive delivery systems for hydrophobic drug molecules compared to hydrophilic drug molecules [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

3 pages, 157 KB

Open AccessAbstract

Synthesis and Preliminary Investigation of Metal Nanoparticles from the Stem Extract of Bacopa sp. for the Treatment of Lung Cancer

by Yogeshwaran Murugan, Selvamani Palanisamy and Latha Subbiah

Proceedings 2024, 100(1), 8; https://doi.org/10.3390/proceedings2024100008 - 27 Mar 2024

Viewed by 1336

Abstract

Lung cancer is the third most common cancer in women and the most common cancer in males. Chemotherapy, allopathy, hormone therapy, radiation therapy, surgery, immune system, and targeted therapies are frequently used to treat lung cancer. These medications induce other diseases and have [...] Read more.

Lung cancer is the third most common cancer in women and the most common cancer in males. Chemotherapy, allopathy, hormone therapy, radiation therapy, surgery, immune system, and targeted therapies are frequently used to treat lung cancer. These medications induce other diseases and have a variety of negative effects. Thus, we used a different strategy and sought to treat lung cancer with medicinal herbs. We selected the perennial creeping herb Bacopa monnieri, which belongs to the Scrophulariaceae family, among other medicinal herbs. It contains several active phytoconstituents, including sterols, alkaloids, flavanoids, terpenoids, and saponins. The primary component with anti-lung cancer efficacy is phytosterol, according to the components. According to the phytochemical investigation, this plant contained it. The literature review indicates that the problem is lessened by nanoparticle production. Thus, the novelty of our work is the manufacture of zinc oxide nanoparticles for the treatment of lung cancer using BM stem extracts. Researchers have been interested in ZnO material because of its huge band gap (3.37 eV) with n-type semi-conductivity and high excitonic binding energy (60 meV) with regards to the different semiconductor nanomaterials, such as TiO₂, SnO₂, GaN, CuO, GaAs, Si, and ZnO. Zinc oxide in bulk is economical and can be used for many different industrial processes, such as the creation of nanoparticles. Zinc acetate serves as the precursor and stem extract serves as the reducing agent in the synthesis. The absorbance peak between 300 and 400 nm in UV spectroscopy was used to characterize the ZnO nanoparticles that were produced from hydromethanolic BM stem extract. In later research, lung cancer treatment might be considered. Given that lung (A549) cell lines will be treated with phytosterol-containing hydromethanolic BM stem extract in the form of ZnO nanoparticles, which will cause cell death by reducing cell proliferation, DNA damage and apoptosis may occur. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 134 KB

Open AccessAbstract

Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting

by Madhumethra Ramasamy Govindaraj, Latha Subbiah and Selvamani Palanisamy

Proceedings 2024, 100(1), 9; https://doi.org/10.3390/proceedings2024100009 - 27 Mar 2024

Viewed by 810

Abstract

Background: Breast cancer is one of the most frequently diagnosed cancers and is the leading cause of death among women worldwide [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 172 KB

Open AccessAbstract

Pharmacological Network Study on the Effect of Quercetin on Gastric Cancer Using Computerized Databases

by Sergio Raúl Zúñiga-Hernández, Trinidad García-Iglesias, Monserrat Macías-Carballo, Juan Manuel Guzmán-Flores and Christian Martin Rodríguez-Razón

Proceedings 2024, 100(1), 10; https://doi.org/10.3390/proceedings2024100010 - 27 Mar 2024

Viewed by 1010

Abstract

Gastric cancer (GC) is the second most common cause of death of any cancer-related cases in the world, and is also in the top 5 most common malignancy cancers in general. There are plenty of well-distributed treatments, offering better hygiene, more robust and [...] Read more.

Gastric cancer (GC) is the second most common cause of death of any cancer-related cases in the world, and is also in the top 5 most common malignancy cancers in general. There are plenty of well-distributed treatments, offering better hygiene, more robust and complete nutrition, and the eradication of pathogens such as Helicobacter pylori. Currently, there is still the need for more treatments, especially those of lower cost, like those coming from already easily available products. Quercetin (QRC) is a natural phenolic compound present in a wide variety of products, e.g., in plants like Hibiscus sabdariffa, onions, grapes, broccoli, and citrus fruits. This product has been shown to have great potential therapeutic effects, and it has also been suggested that it could be useful in combating different types of cancer; however, information regarding the targets or mechanisms that QRC has on cancer cells is still unclear. Therefore, this study aims to identify the targets that QRC has, like anti-cancer treatment for GC using different bio-informatic tools and databases. From MalaCards and SwissTargetPrediction, both QRC and GC molecular targets were defined, and then they were matched with the Venny 2.1.0 platform. From this, 31 genes were gathered, and then they were analyzed using the ShinnyGo0.77 and DAVID-Bioinformatic Resources. Furthermore, StringDB was used to identify the protein—protein interactions, and Citoscape 3.6.0 12 hub genes were obtained. Those hub genes were then subject to Gene Expression Profiling Interactive Analysis and TISIDB. Finally, molecular docking studies were performed using the SwissDock database. The results suggest that, according to the gene ontology data, QRC has a relationship with the regulation of cell death, response to stress, cell motility, response to amyloid-beta, cellular response to reactive oxygen species, and apoptotic processes. Some genes like EGFR were correlated with an abundance of CD8 and Neutrophil infiltration but didn’t show to improve the survival rate. Furthermore, molecular docking results show that QRC can bind to multiple molecules of interest. These results complement some of the currently available information alluding to the effectiveness of plants rich with QRC as part of the treatment used for different kinds of cancer, but it also suggests a plethora of new targets that this molecule has in GC, while at the same time giving a clearer idea of the mechanisms that are affected in GC by QRC. However, as with any other study that primarily uses bioinformatic tools, these final results are to be used for more direct and precise research, especially if experimental protocols are used. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 145 KB

Open AccessAbstract

Differential Expression Analysis in Genes Associated with the Mitochondrial Metabolism Reveals a Potential Influence on the Progression of Glioblastoma from Astrocytoma

by Ricardo Cunha de Oliveira and Giovanna Chaves Cavalcante

Proceedings 2024, 100(1), 11; https://doi.org/10.3390/proceedings2024100011 - 27 Mar 2024

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Abstract

The most common forms of primary brain tumors are low-grade astrocytoma (ACT) tumors and their progression to the glioblastoma multiforme (GBM), in a high-aggressiveness form. Understanding mechanisms of progression is necessary, and mitochondrial mechanisms are not yet as well elucidated and may be [...] Read more.

The most common forms of primary brain tumors are low-grade astrocytoma (ACT) tumors and their progression to the glioblastoma multiforme (GBM), in a high-aggressiveness form. Understanding mechanisms of progression is necessary, and mitochondrial mechanisms are not yet as well elucidated and may be a factor in this disease. Therefore, in this study, we analyzed differential gene expression (DGE) between GBM and ACT, using the MitoXplorer 2.0 to screen nuclear genes involved in mitochondrial metabolism, totaling 1193 genes. The analysis used ACT (n = 195) and GBM (n = 157) samples made available by The Cancer Genome Atlas (TCGA) database. As a complement, we checked the expression of differentially expressed genes (DEGs) in normal tissues using the GTEx Portal, as well as checking disease-free survival (DFS) using GEPIA2. DGE showed five potential DEGs, three of which were downregulated (ACSM2A, ACSM2B, and PRODH2) and two were upregulated (TERT and FBP2). In non-cancerous tissues, upregulated DEGs are normally expressed basally in brain tissue and TERT is normally expressed in tissues such as testis and small intestine, while FBP2 is expressed in the stomach, skeletal muscle, testis, pancreas, and adrenal glands. Alternatively, downregulated DEGs normally show basal or zero expression in brain tissues and are normally expressed in the liver and kidneys. DFS analysis showed that the high expression of the TERT is associated with poor survival, and is the only gene found to be significant among the five DEGs (p-value 0.05). Briefly, our analyses showed five mitochondrial DEGs as potential markers of GBM progression in relation to ACT. Four of the five DEGs have not been reported as factors that can influence the GBM cascade until this work, while the TERT gene has already been indicated as a potential biomarker of brain cancer, having an essential function in the protection of the mitochondrial genome. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

1 pages, 115 KB

Open AccessAbstract

Machine Learning Strategies for Drug Discovery in AML: Focus on RUNX1 Bioactivity

by Deepesh Kumar Verma

Proceedings 2024, 100(1), 12; https://doi.org/10.3390/proceedings2024100012 - 27 Mar 2024

Viewed by 869

Abstract

Acute myeloid leukemia (AML) is an aggressive blood cancer where immature stem cells in the bone marrow multiply rapidly, disrupting blood cell production and leading to infections, anemia, and bleeding [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 135 KB

Open AccessAbstract

Chordoma Treatment with Boron Neutron Capture Therapy (BNCT): Experimental Insights

by Yoshiki Fujikawa, Shinji Kawabata, Kohei Tsujino, Hideki Kashiwagi, Yusuke Fukuo, Ryo Hiramatsu, Hiroki Tanaka, Naonori Hu, Toshihiro Takami and Masahiko Wanibuchi

Proceedings 2024, 100(1), 13; https://doi.org/10.3390/proceedings2024100013 - 27 Mar 2024

Viewed by 810

Abstract

Boron Neutron Capture Therapy (BNCT) is a particle beam therapy that enables the precise targeting of tumors at the cellular level [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 161 KB

Open AccessAbstract

Polycyclic Aromatic Hydrocarbons (PAHs) in Grilled Marshmallows

by Maciej Maciejczyk, Beata Janoszka, Magdalena Szumska, Beata Pastuszka, Sławomir Waligóra, Aleksandra Damasiewicz-Bodzek, Agnieszka Nowak and Krystyna Tyrpień-Golder

Proceedings 2024, 100(1), 14; https://doi.org/10.3390/proceedings2024100014 - 27 Mar 2024

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Abstract

Introduction [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 146 KB

Open AccessAbstract

Evaluation of the Safety of Folate Receptor-Targeted Boron Carrier in Boron Neutron Capture Therapy (BNCT) for Malignant Gliomas Using CED Administration

by Kohei Tsujino, Hideki Kashiwagi, Ryo Kayama, Yoshiki Fujikawa, Yusuke Fukuo, Ryo Hiramatsu, Naosuke Nonoguchi, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Naonori Hu, Masahiko Wanibuchi, Kei Nakai, Kai Nishimura, Hiroyuki Nakamura and Shinji Kawabata

Proceedings 2024, 100(1), 15; https://doi.org/10.3390/proceedings2024100015 - 27 Mar 2024

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Abstract

Knowing how to accumulate boron into the tumor cells is a crucial aspect of boron neutron capture therapy (BNCT), which can be targeted at the cellular level, and the development of novel boron agents other than BPA, which is used in clinical practice, [...] Read more.

Knowing how to accumulate boron into the tumor cells is a crucial aspect of boron neutron capture therapy (BNCT), which can be targeted at the cellular level, and the development of novel boron agents other than BPA, which is used in clinical practice, is urgently needed [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 160 KB

Open AccessAbstract

Post-GWAS Functional Analysis of the 11p11.2 Risk Locus Identifies HSD17B12 as a Neuroblastoma Susceptibility Gene Involved in Lipid Metabolism

by Teresa Maiorino, Marianna Avitabile, Vito Alessandro Lasorsa, Annalaura Montella, Sueva Cantalupo, Matilde Tirelli, Martina Morini, Alessandra Eva, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon and Mario Capasso

Proceedings 2024, 100(1), 16; https://doi.org/10.3390/proceedings2024100016 - 27 Mar 2024

Viewed by 803

Abstract

Genome-wide association studies (GWASs) have contributed to the study of neuroblastoma (NB) genetics by identifying common risk variants that activate cancer-related processes associated with NB susceptibility [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 150 KB

Open AccessAbstract

Deciphering the Role of USP16 in Lung Cancer

by Valentina Serratore, Carmen Di Ruocco, Annamaria Cerantonio, Carmela De Marco and Giuseppe Viglietto

Proceedings 2024, 100(1), 17; https://doi.org/10.3390/proceedings2024100017 - 27 Mar 2024

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Abstract

Deubiquitylating enzymes are proteases that reverse the ubiquitination of proteins, an important process for maintaining normal homeostasis [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 170 KB

Open AccessAbstract

Noncoding Regulatory Mutations as a Driving Event for the Oncogenic Core Regulatory Circuitries of Neuroblastoma

by Vincenzo Aievola, Vito Alessandro Lasorsa, Annalaura Montella, Ferdinando Bonfiglio, Marianna Avitabile, Teresa Maiorino, Matilde Tirelli, Giuseppe D’Alterio, Matthias Fischer, Frank Westermann, Achille Iolascon and Mario Capasso

Proceedings 2024, 100(1), 18; https://doi.org/10.3390/proceedings2024100018 - 27 Mar 2024

Viewed by 800

Abstract

Neuroblastoma (NB) is a pediatric tumor composed of adrenergic (ADRN) and mesenchymal-like (MES) cells which derive from the dysregulation of normal cell differentiation imposed by NB Core Regulatory Circuitries (CRCs) [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 143 KB

Open AccessAbstract

Exposure to Mycovirus-Containing Aspergillus flavus Alters Transcription Factors in Normal and Leukemia Cell Lines

by Cameron K. Tebbi, Eva Sahakian, Jiyu Yan, Saumil Patel and Melanie Mediavilla-Varela

Proceedings 2024, 100(1), 19; https://doi.org/10.3390/proceedings2024100019 - 27 Mar 2024

Cited by 2 | Viewed by 951

Abstract

Transcription factors bind specific DNA motifs to regulate the expression of target genes in order to maintain normal hematopoiesis [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 139 KB

Open AccessAbstract

Exploring the Antimicrobial and Anticancer Potential of a Bioactive Peptide from T. radiatus: A Comprehensive Study

by Krishnanand Nagarajan, Latha Subbaiah and Selvamani Palanisamy

Proceedings 2024, 100(1), 20; https://doi.org/10.3390/proceedings2024100020 - 27 Mar 2024

Cited by 1 | Viewed by 759

Abstract

Therapeutic peptides have emerged as a promising frontier in the development of anti-cancer agents, classified into three main groups: antimicrobial/pore-forming peptides, cell-permeable peptides, and tumor-targeting peptides [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 141 KB

Open AccessAbstract

Cancer Stem Cells as Potential Targets of Phytotoxic Alkaloids: Drug-Likeness Prediction and Molecular Docking Studies

by Charles Okeke Nnadi, Simnom Hope Banda, Michael Uchechukwu Uzonwanne and Obinna Kenneth Didigwu

Proceedings 2024, 100(1), 21; https://doi.org/10.3390/proceedings2024100021 - 27 Mar 2024

Cited by 1 | Viewed by 873

Abstract

Targeting cancer stem cells (CSCs) in anticancer discovery is very difficult due to the resistance of CSCs to conventional drugs, their low proliferation rate, improved DNA damage repair, and the overexpression of anti-apoptotic proteins and multidrug resistance transporters. Different CSC targets, such as [...] Read more.

Targeting cancer stem cells (CSCs) in anticancer discovery is very difficult due to the resistance of CSCs to conventional drugs, their low proliferation rate, improved DNA damage repair, and the overexpression of anti-apoptotic proteins and multidrug resistance transporters. Different CSC targets, such as the ABC cassette, surface markers, signal cascade, and tumour microenvironment, are involved in the interruption of cell signaling pathways that are critical for the survival and functioning of the CSC population. The study aims to identify potential drug-like phytotoxic alkaloids with anticancer activity from the toxic plants-phytotoxins (TPPTs) database. A total of 1586 phytotoxins were filtered to obtain 653 alkaloids. Lipinski’s properties and the TPSA of alkaloids were predicted for drug likeness and toxicity based on various organ endpoints. Compounds that obeyed Lipinski’s rule of five, with moderate or no toxicity and an LD₅₀ of >2000 mg/kg, were selected. The 12 drug-like phytotoxic alkaloids obtained from the filtering were docked on an isomerase-perdeuterated E65Q-TIM protein (ID: 7AZA; resolution = 1.10 Å) cocrystallized with phosphoglycolohydroxamate. The best binding poses were ranked using their binding energies (E) and inhibition constants (Ki). An evaluation of the protein—ligand’s best conformational poses allowed us to identify three alkaloids (norcoclaurine, palustridiene, and apovincamine) with Ki 1.00 µM and E −9.00 kcal/mol. All the docked ligands could bind more efficiently to the isomerase-perdeuterated E65Q-TIM protein than the co-crystallized phosphoglycolohydroxamate. Significant protein—ligand binding interactions also occurred for (-)-eburnamonine (E = −8.03 kcal/mol; Ki = 1.30 µM) and retamine (E = −7.81 kcal/mol; Ki = 1.89 µM). The efficient inhibition of perdeuterated E65Q-TIM in CSCs using phytotoxic alkaloids provided more insights into understanding the mechanisms of the anticancer activity of phytotoxic alkaloids. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 127 KB

Open AccessAbstract

Metabolic Strategies of Treg Cells in the Tumor Microenvironment: Implications for Immune Metabolism-Based Precision Medicine

by Devendra Kumar Mishra, Sandeep Yadav, Sumit Chaudhari, Ila Dixit, Lavkush Tiwari, Khalid Abdul Waheed, Shubham Shukla and Savita Upadhyay

Proceedings 2024, 100(1), 22; https://doi.org/10.3390/proceedings2024100022 - 27 May 2024

Viewed by 1023

Abstract

In recent years, the complex relationship between immune cells and the area around the tumour has become an important factor in how cancer grows and how well treatment works [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 128 KB

Open AccessAbstract

Unveiling the Smell of Health: E-Nose-Based Volatile Organic Compound Analysis of Exhaled Breath in Early Lung Cancer Detection

by V. A. Binson and Sania Thomas

Proceedings 2024, 100(1), 23; https://doi.org/10.3390/proceedings2024100023 - 29 May 2024

Viewed by 2439

Abstract

Lung cancer remains a formidable global health challenge, necessitating the exploration of innovative diagnostic approaches for early detection. This review paper delves into the burgeoning field of exhaled breath analysis using electronic nose (e-nose) technology for the identification of volatile organic compounds (VOCs) [...] Read more.

Lung cancer remains a formidable global health challenge, necessitating the exploration of innovative diagnostic approaches for early detection. This review paper delves into the burgeoning field of exhaled breath analysis using electronic nose (e-nose) technology for the identification of volatile organic compounds (VOCs) as potential biomarkers for lung cancer diagnosis. An electronic nose inspired by the human olfactory system comprises an array of sensors that can detect and differentiate complex odor profiles. This paper elucidates the principles behind e-nose technology and its application in capturing the unique VOC signatures present in exhaled breath, which serve as indicators of underlying physiological conditions. A significant portion of this review is dedicated to elucidating the methodology and advancements in e-nose-based VOC analysis, providing insights into the potential of this non-invasive approach for disease diagnosis. The exploration extends beyond general applications to specifically spotlight the utilization of e-nose technology in the realm of early lung cancer detection. E-nose-based disease diagnosis, and more specifically, lung cancer detection, is discussed in detail, with an emphasis on the recent studies and advancements. The potential of VOC profiling as a reliable and early diagnostic tool for lung cancer is explored, addressing both the promises and challenges associated with this cutting-edge approach. This comprehensive review amalgamates the current state of knowledge in the field, offering a roadmap for future research opportunities and the realization of e-nose technology’s promise in revolutionizing lung cancer diagnosis. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

2 pages, 132 KB

Open AccessAbstract

Oncolytic Viral Therapy with Gravity Approaching Zero to Ameliorate Glioblastoma Multiforme

by Tarek Elshourbagy and James Robert Brašić

Proceedings 2024, 100(1), 24; https://doi.org/10.3390/proceedings2024100024 - 27 Mar 2024

Viewed by 692

Abstract

Glioblastoma multiforme (GBM) is the most common aggressive malignant primary brain tumor, afflicting approximately 3 in every 100,000 persons in the United States, with an incidence rate that is 1 [...] Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Cancers)

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