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Abstract

Cytotoxicity of Glyphosate Studied in Selected Human Cell Lines †

by
Agata Jabłońska-Trypuć
1,*,
Gabriela Sokołowska
1,
Monika Naumowicz
2,
Urszula Wydro
1 and
Elżbieta Wołejko
1
1
Department of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bialystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland
2
Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K Street, 15-245 Bialystok, Poland
*
Author to whom correspondence should be addressed.
†
Presented at the 1st International Electronic Conference on Toxics, 20–22 March 2024; Available online: https://sciforum.net/event/IECTO2024.
Proceedings 2024, 102(1), 13; https://doi.org/10.3390/proceedings2024102013
Published: 3 April 2024
Versions Notes

Introduction: Glyphosate is a phosphonate herbicide that has been used for 35 years, and it is still the most widely used herbicide in the world. The development of modern methods of in vitro toxicological analysis and the obvious increase in exposure to glyphosate have made it an increasingly studied xenobiotic. The widespread use of pesticides, especially glyphosate, causes large amounts to be released into the environment, where they pose a threat to entire ecosystems.
Methods: In our research, we focused on the best research model from the point of view of toxicology, in which human cell lines were used in order to test the cytotoxicity of glyphosate. The tested concentrations of this compound reflected the level of human exposure to this active substance and ranged from 0.01 mM to 10 mM. The analyzes were conducted on the human cell lines: MCF-7, T98G and DLD-1. In order to estimate the cytotoxicity of this herbicide, an MTT assay was used.
Results: A significant increase in cancer cell viability was observed under the influence of the studied concentrations of glyphosate. The effect was significant, especially under the influence of the lower concentrations studied.
Conclusions: The obtained results indicate the carcinogenic and tumor cell-stimulating effects of glyphosate. This indicates the need for the prudent use and monitoring of glyphosate in the environment due to its potentially hazardous effects on human health.

Author Contributions

Conceptualization, A.J.-T., G.S. and E.W.; methodology, A.J.-T., G.S., U.W., E.W. and M.N.; software, A.J.-T. and U.W.; validation, E.W. and U.W.; formal analysis, A.J.-T. and M.N.; investigation, A.J.-T., G.S., M.N., U.W. and E.W.; resources, A.J.-T., E.W. and U.W.; data curation, G.S., E.W. and U.W.; writing—original draft preparation, A.J.-T., G.S., E.W. and U.W.; writing—review and editing, A.J.-T., G.S., E.W., U.W. and M.N.; visualization, E.W., U.W. and A.J.-T.; supervision, A.J.-T.; project administration, A.J.-T.; funding acquisition, A.J.-T., E.W. and U.W. All authors have read and agreed to the published version of the manuscript.

Funding

This work was financially supported by the Ministry of Education and Science, Poland, under the research project number WZ/WB-IIŚ/6/2022.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

The data presented in this study are available on a reasonable request from the corresponding author.

Conflicts of Interest

The authors declare no conflicts of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Jabłońska-Trypuć, A.; Sokołowska, G.; Naumowicz, M.; Wydro, U.; Wołejko, E. Cytotoxicity of Glyphosate Studied in Selected Human Cell Lines. Proceedings 2024, 102, 13. https://doi.org/10.3390/proceedings2024102013

AMA Style

Jabłońska-Trypuć A, Sokołowska G, Naumowicz M, Wydro U, Wołejko E. Cytotoxicity of Glyphosate Studied in Selected Human Cell Lines. Proceedings. 2024; 102(1):13. https://doi.org/10.3390/proceedings2024102013

Chicago/Turabian Style

Jabłońska-Trypuć, Agata, Gabriela Sokołowska, Monika Naumowicz, Urszula Wydro, and Elżbieta Wołejko. 2024. "Cytotoxicity of Glyphosate Studied in Selected Human Cell Lines" Proceedings 102, no. 1: 13. https://doi.org/10.3390/proceedings2024102013

APA Style

Jabłońska-Trypuć, A., Sokołowska, G., Naumowicz, M., Wydro, U., & Wołejko, E. (2024). Cytotoxicity of Glyphosate Studied in Selected Human Cell Lines. Proceedings, 102(1), 13. https://doi.org/10.3390/proceedings2024102013

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