Modelling the Current Response and Sensitivity of Oxidase Enzyme Electrodes, Monitored Amperometrically by the Consumption of Oxygen
Round 1
Reviewer 1 Report
In my opinion the Manuscript electrochem-1730555 entitled "Modelling the Amperometric Current and Sensitivity of Oxidase Enzyme Electrodes, Monitored by The Consumption of Oxygen” is suitable for publication in the Elechtrochem journal after revision.
The manuscript includes important issues that may be of interest to a broad chemical engineering and/or applied electrochemistry audience. The applied calculation method is adequate to the undertaken considerations. Conclusions are related to the obtained results.
Remarks:
- Figure 4: the colors of the chart were chosen not very well, especially in the chart marked as (b) it is not known whether the upper left part of the chart is the front or back of the designated plane.
- pay attention to the format, Mathematical formulation should be Mathematical Formulation in 76; Using The AGM should be Using the AGM in line 125, etc. All section titles should be checked.
Author Response
- General comment: In my opinion the Manuscript electrochem-1730555 entitled "Modelling the Amperometric Current and Sensitivity of Oxidase Enzyme Electrodes, Monitored by The Consumption of Oxygen” is suitable for publication in the Elechtrochem journal after revision.
The manuscript includes important issues that may be of interest to a broad chemical engineering and/or applied electrochemistry audience. The applied calculation method is adequate to the undertaken considerations. Conclusions are related to the obtained results.
Response: The authors thank reviewer 1 for these kind comments. It is much appreciated.
- Comment: Figure 4: the colours of the chart were chosen not very well, especially in the chart marked as (b) it is not known whether the upper left part of the chart is the front or back of the designated plane.
Reply: We thank the reviewer for this useful comment.A new figure 4 has been redrawn which should make the figures clearer. Both front and rear sides of the flux surface are displayed.
- Pay attention to the format, Mathematical formulation should be Mathematical Formulation in 76; Using The AGM should be Using the AGM in line 125, etc. All section titles should be checked.
Reply: These typographical errors have been addressed. Changes to the text body are coloured in yellow highlight in revised manuscript.
Sincerely
Professor Mike Lyons
Reviewer 2 Report
The present manuscript deals with the solution of nonlinear differential equations that can be used to describe the behavior of enzyme-based amperometric sensors, focusing particularly on the determination of the mediator ans substrate concentration in the case of oxidase enzyme electrodes. Such type of sensors have been extensively studied in academic and applied fields due to their scientific significance and commercial value, and the corresponding author of the present paper has done groundbreaking work in the field of enzyme electrodes.
This ms. is also an interesting study which merits publication in "electrochem", however, there are a number of issues that need addressing before it should be accepted.
Special points:
l.1-3 (title): In my opinion the title should be clarified to indicate that the study seeks to determine the mediator and substrate concentration.
l.73: "Using AGM method ..."
The abbreviation AGM should be explained here. Ref. [28]?
l.77-81: The wording is confusing. Who extended the theory to what?
l.91: km should read as k1
Equation (3),(5): y should be italic
l.104: y should be italic.
l.116: "The Non-dimensionalising ..." n should be lowercase.
l.125: "Using The AGM" t should be lowercase.
Figs. 1.(a),(b),(c), 2.(a),(b),(c): The abscissa axis labels should be corrected.
l.179: "4.2.2. ..." The title should be checked.
l.186: J should be italic.
l.204, 205, 207, 211, etc.: SI units should be written in an upright typeface with a space between the numeric quantity value and the unit symbol.
l.234: "Notations" instead of "Notaions"
In this section: the notation for "Normalized distance" here differs from the notation in the text (X ?).
Equations (A3), (A6), l.247: Letter X rather than letter chi.
Author Response
Response to Reviewer 2
General comment: The present manuscript deals with the solution of nonlinear differential equations that can be used to describe the behavior of enzyme-based amperometric sensors, focusing particularly on the determination of the mediator ans substrate concentration in the case of oxidase enzyme electrodes. Such type of sensors have been extensively studied in academic and applied fields due to their scientific significance and commercial value, and the corresponding author of the present paper has done groundbreaking work in the field of enzyme electrodes.
This ms. is also an interesting study which merits publication in "electrochem", however, there are a number of issues that need addressing before it should be accepted.
Response; The authors thank the reviewer for their positive and encouraging comments.
Reviewer 2 Special points:
l.1-3 (title): In my opinion the title should be clarified to indicate that the study seeks to determine the mediator and substrate concentration.
l.73: "Using AGM method ..."
The abbreviation AGM should be explained here. Ref. [28]?
l.77-81: The wording is confusing. Who extended the theory to what?
l.91: km should read as k1
Equation (3),(5): y should be italic
l.104: y should be italic.
l.116: "The Non-dimensionalising ..." n should be lowercase.
l.125: "Using The AGM" t should be lowercase.
Figs. 1.(a),(b),(c), 2.(a),(b),(c): The abscissa axis labels should be corrected.
l.179: "4.2.2. ..." The title should be checked.
l.186: J should be italic.
l.204, 205, 207, 211, etc.: SI units should be written in an upright typeface with a space between the numeric quantity value and the unit symbol.
l.234: "Notations" instead of "Notaions"
In this section: the notation for "Normalized distance" here differs from the notation in the text (X ?).
Equations (A3), (A6), l.247: Letter X rather than letter chi.
We thank the reviewer for their excellent comments.
Mike Lyons
