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Reprod. Med.
Volume 5
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10.3390/reprodmed5040018
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Case Report

Uterus Didelphys with Hematocervix in the Unilateral Obstructed Hemivagina and Ipsilateral Renal Agenesis: A Case Report of Herlyn–Werner–Wunderlich Syndrome

by
Cristina Taliento
1,2,*,†,
Alba Rondoni
1,†,
Gennaro Scutiero
1,
Matteo Pavone
2,3,4,
Matteo Mordenti
5,
Giuseppe Vizzielli
6,7 and
Pantaleo Greco
1
1
Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, 44121 Ferrara, Italy
2
Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, 00168 Rome, Italy
3
Dipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
4
IHU Strasbourg, Institute of Image-Guided Surgery, 67000 Strasbourg, France
5
Radiology Unit, Ospedale SS. Annunziata, 66100 Cento, Italy
6
Department of Medicine (DMED), University of Udine, 33100 Udine, Italy
7
Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Reprod. Med. 2024, 5(4), 197-203; https://doi.org/10.3390/reprodmed5040018
Submission received: 25 July 2024 / Revised: 19 September 2024 / Accepted: 25 September 2024 / Published: 1 October 2024
Versions Notes

Abstract

Background: Mullerian duct anomalies include a broad spectrum of genital tract defects that arise from developmental abnormalities of the genital tract. Herlyn–Werner–Wunderlich syndrome (HWWS) refers to the combination of uterus didelphys, blind hemivagina and ipsilateral renal agenesis. In the literature, the syndrome often appears as a few sporadic case reports. Case: We report a case of symptomatic Herlyn–Werner–Wunderlich syndrome diagnosed by transavaginal scan and MRI and successfully treated with a laparoscopic-assisted hysteroscopic vaginal septum resection. The postoperative course was without complications, and clinical symptoms completely resolved the surgery. Summary and Conclusion: Combination of laparoscopy and hysteroscopy was found to be an easy, safe, effective and appropriate approach for patients with HWWS.
Keywords: OHVIRA; Herlyn–Werner–Wunderlich syndrome; HWWS; Mullerian duct anomalies OHVIRA; Herlyn–Werner–Wunderlich syndrome; HWWS; Mullerian duct anomalies

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MDPI and ACS Style

Taliento, C.; Rondoni, A.; Scutiero, G.; Pavone, M.; Mordenti, M.; Vizzielli, G.; Greco, P. Uterus Didelphys with Hematocervix in the Unilateral Obstructed Hemivagina and Ipsilateral Renal Agenesis: A Case Report of Herlyn–Werner–Wunderlich Syndrome. Reprod. Med. 2024, 5, 197-203. https://doi.org/10.3390/reprodmed5040018

AMA Style

Taliento C, Rondoni A, Scutiero G, Pavone M, Mordenti M, Vizzielli G, Greco P. Uterus Didelphys with Hematocervix in the Unilateral Obstructed Hemivagina and Ipsilateral Renal Agenesis: A Case Report of Herlyn–Werner–Wunderlich Syndrome. Reproductive Medicine. 2024; 5(4):197-203. https://doi.org/10.3390/reprodmed5040018

Chicago/Turabian Style

Taliento, Cristina, Alba Rondoni, Gennaro Scutiero, Matteo Pavone, Matteo Mordenti, Giuseppe Vizzielli, and Pantaleo Greco. 2024. "Uterus Didelphys with Hematocervix in the Unilateral Obstructed Hemivagina and Ipsilateral Renal Agenesis: A Case Report of Herlyn–Werner–Wunderlich Syndrome" Reproductive Medicine 5, no. 4: 197-203. https://doi.org/10.3390/reprodmed5040018

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